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Literature summary for 2.7.11.24 extracted from

  • Lee, P.Y.; Tsai, P.S.; Huang, Y.H.; Huang, C.J.
    Inhibition of toll-like receptor-4, nuclear factor-kappaB and mitogen-activated protein kinase by lignocaine may involve voltage-sensitive sodium channels (2008), Clin. Exp. Pharmacol. Physiol., 35, 1052-1058.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information lipolysaccharide induces the MAPK activation, which is inhibited by lignocaine in case of ERK and p38, but not of JNK, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
lignocaine the enzyme inhibition by lignocine may involve voltage-sensitive sodium channels, the enzyme attenuates the induction of MAPK activation by lipopolysaccharides, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus MAPKs are involved in the upstream regulation of inducible nitric oxide synthase, iNOS ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MAPKs are involved in the upstream regulation of inducible nitric oxide synthase, iNOS Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
c-Jun N-terminal kinase
-
 Mus musculus
ERK
-
 Mus musculus
extracellular regulated kinase
-
 Mus musculus
JNK
-
 Mus musculus
MAPK
-
 Mus musculus
p38
-
 Mus musculus