Application | Comment | Organism |
---|---|---|
drug development | Echinococcus multilocularis MPK2 is a promising target for the development of drugs against alveolar echinococcosis | Echinococcus multilocularis |
Cloned (Comment) | Organism |
---|---|
gene mpk2, DNA and amino acid sequence determination and analysis, sequence comparison, expression of the His-tagged enzyme in Escherichia coli | Echinococcus multilocularis |
isozyme p38 MAPKalpha, sequence comparison, expression of the His-tagged enzyme in Escherichia coli | Echinococcus multilocularis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ML3403 | an ATP-competitive pyridinyl imidazole inhibitor of p38 MAPK; an ATP-competitive pyridinyl imidazole inhibitor of p38 MAPK, leads to strong dephosphorylation of MPK2 in the parasite and effective killing of parasite vesicles at concentrations that do not affect cultivated mammalian cells; an ATP-competitive pyridinyl imidazole inhibitor of p38 MAPK, leads to strong dephosphorylation of MPK2 in the parasite and effective killing of parasite vesicles at concentrations that do not affect cultivated mammalian cells | Echinococcus multilocularis | |
SB202190 | an ATP-competitive pyridinyl imidazole inhibitor of p38 MAPK; an ATP-competitive pyridinyl imidazole inhibitor of p38 MAPK, leads to dephosphorylation of MPK2 in the parasite and effective killing of parasite vesicles at concentrations that do not affect cultivated mammalian cells; an ATP-competitive pyridinyl imidazole inhibitor of p38 MAPK, leads to dephosphorylation of MPK2 in the parasite and effective killing of parasite vesicles at concentrations that do not affect cultivated mammalian cells | Echinococcus multilocularis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Echinococcus multilocularis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Echinococcus multilocularis | - |
fox-tapeworm | - |
Echinococcus multilocularis | B1VK39 | MPK2, cDNA; fox-tapeworm, gene mpk2 | - |
Echinococcus multilocularis | B1VK40 | MPK2, chromosomal DNA; fox-tapeworm, gene mpk2 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | MPK2 is highly autophosphorylated | Echinococcus multilocularis |
phosphoprotein | p38 MAP kinase is activated by autophosphorylation | Echinococcus multilocularis |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged enzyme from Escherichia coli by affinity chromatography | Echinococcus multilocularis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | primary cell culture established from metacestode vesicle | Echinococcus multilocularis | - |
larva | metacestode larval stage, expression analysis of mpk2 | Echinococcus multilocularis | - |
metacestode | - |
Echinococcus multilocularis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myelin basic protein | - |
Echinococcus multilocularis | ADP + phosphorylated myelin basic protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAPK | - |
Echinococcus multilocularis |
More | MPK2 is a member of the mitogen-activated protein kinase, MAPK, family | Echinococcus multilocularis |
More | p39 MAPK is a member of the mitogen-activated protein kinase, MAPK, family | Echinococcus multilocularis |
MPK2 | - |
Echinococcus multilocularis |
p38 MAP kinase | - |
Echinococcus multilocularis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Echinococcus multilocularis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Echinococcus multilocularis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Echinococcus multilocularis |