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Literature summary for 2.7.11.24 extracted from

  • Kawasaki, T.; Choudhry, M.A.; Schwacha, M.G.; Fujimi, S.; Lederer, J.A.; Bland, K.I.; Chaudry, I.H.
    Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process (2008), Am. J. Physiol. Cell Physiol., 294, C754-C764.
    View publication on PubMed
Search for more literature for 2.7.11.24

Activating Compound

Activating Compound Comment Organism Structure
additional information MAPKs are activated by phosphorylation through MAPK kinases Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
II/SP600125 inhibits SAPK/JNK; inhibits SAPK/JNK; inhibits SAPK/JNK Mus musculus
additional information PD98059 inhibits the activation of ERK1/2 with a IC50 value of 0.002 mM; PD98059 inhibits the activation of ERK1/2 with a IC50 value of 0.002 mM Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus trauma-hemorrhage suppresses MAPK phosphorylation and activation in lipopolysaccharide-unstimulated splenic dendritic cells, in lipopolysaccharide-unstimulated cells the activation is increased, modeling, overview ?
-
 ?
additional information Mus musculus trauma-hemorrhage suppresses MAPK phosphorylation and activation in lipopolysaccharide-unstimulated splenic dendritic cells, in lipopolysaccharide-unstimulated cells the activation is increased, modelling, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male C3H/HeN mice
-
Mus musculus Q61831 JNK3; male C3H/HeN mice
-
Mus musculus Q91Y86 JNK1; male C3H/HeN mice
-
Mus musculus Q9WTU6 JNK2; male C3H/HeN mice
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein MAPKs are activated by phosphorylation through MAPK kinases Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell splenic Mus musculus
-
spleen
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information trauma-hemorrhage suppresses MAPK phosphorylation and activation in lipopolysaccharide-unstimulated splenic dendritic cells, in lipopolysaccharide-unstimulated cells the activation is increased, modeling, overview Mus musculus ?
-
 ?
additional information trauma-hemorrhage suppresses MAPK phosphorylation and activation in lipopolysaccharide-unstimulated splenic dendritic cells, in lipopolysaccharide-unstimulated cells the activation is increased, modelling, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
ERK1/2
-
 Mus musculus
JNK-1
-
 Mus musculus
JNK-2
-
 Mus musculus
JNK-3
-
 Mus musculus
p38
-
 Mus musculus
SAPK/JNK
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00004
-
 inhibition of JNK1 Mus musculus II/SP600125
0.00004
-
 inhibition of JNK2 Mus musculus II/SP600125
0.00009
-
 inhibition of JNK3 Mus musculus II/SP600125