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Literature summary for 2.7.11.24 extracted from
- Cloning and characterisation of p38 MAP kinase from Atlantic salmon A kinase important for regulating salmon TNF-2 and IL-1beta expression (2007), Mol. Immunol., 44, 3137-3146.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | lipopolysaccharide, CpG oligonucleotides and recombinant trout IL-1beta induce endogenous phosphorylation of p38 in a dose-dependent manner | Salmo salar | |
| sodium arsenite | - |
Salmo salar |  |
| sorbitol | - |
Salmo salar | |
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | p38 MAPK signalling pathway has a role in mediating immune and stress response in fish, shows more than 85% identity to the mammalian homolog p38alpha, contains the conserved phosphorylation motif TGY located in the activation loop of the kinase | Salmo salar |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| CHSE-214 cells transiently transfected with plasmid encoding p38a N-terminally Myc-tagged | Salmo salar |
| CHSE-214 cells transiently transfected with plasmid encoding p38b1 N-terminally Myc-tagged | Salmo salar |
| CHSE-214 cells transiently transfected with plasmid encoding p38b2 N-terminally Myc-tagged | Salmo salar |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| SB203580 | blocks stress-induced phosphorlyation of MK2 in CHSE-214 cells; blocks stress-induced phosphorlyation of MK2 in CHSE-214 cells; blocks stress-induced phosphorlyation of MK2 in CHSE-214 cells, completely abolishes LPS-stimulated TNF-2 and IL-1beta mRNA expression in macrophages | Salmo salar | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Salmo salar | A1ED58 | - |
- |
| Salmo salar | A1ED59 | - |
- |
| Salmo salar | A9UJZ9 | - |
- |
| Salmo salar Aquagen standard | A1ED58 | - |
- |
| Salmo salar Aquagen standard | A1ED59 | - |
- |
| Salmo salar Aquagen standard | A9UJZ9 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gill | - |
Salmo salar | - |
| heart | - |
Salmo salar | - |
| kidney | - |
Salmo salar | - |
| liver | - |
Salmo salar | - |
| macrophage | - |
Salmo salar | - |
| additional information | head kidney | Salmo salar | - |
| ovary | highly expressed | Salmo salar | - |
| ovary | higher expression than in the other organs | Salmo salar | - |
| spleen | - |
Salmo salar | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + MK2 | - |
Salmo salar | ADP + phosphorylated MK2 | - |
? | |
| ATP + MK2 | - |
Salmo salar Aquagen standard | ADP + phosphorylated MK2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| p38 MAPK | - |
Salmo salar |
| p38 mitogen-activated protein kinase | - |
Salmo salar |
| p38a | - |
Salmo salar |
| p38b1 | - |
Salmo salar |
| p38b2 | - |
Salmo salar |
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