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Literature summary for 2.7.11.24 extracted from

  • Hedrick, M.N.; Olson, C.M.; Conze, D.B.; Bates, T.C.; Rincon, M.; Anguita, J.
    Control of Borrelia burgdorferi-specific CD4+-T-cell effector function by interleukin-12- and T-cell receptor-induced p38 mitogen-activated protein kinase activity (2006), Infect. Immun., 74, 5713-5717.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine role in immune response to the spirochete of Borrelia burgdorferi mediated by CD4+ T cells, p38 MAP kinase pathway mediates production of IFN-gamma in response to a specific antigen, IL-12 contributes to IFN-gamma production by Borrelia burgdorferi specific effector Th1 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information transgenic mice expressing a dominant negative mutant MAP kinase, inhibits the activity of endogenous p38 MAP kinase and reduces levels of IFN-gamma in serum Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
SB203580 inhibits p38 MAP kinase in T cells, administration of the pharmacological inhibitor of the kinase during the course of infection with the spirochete Borrelia burgdorferi results in reduced levels of IFN-gamma in the sera of infected mice Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C3H/HeN mice
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Mus musculus C3H/HEN
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 C3H/HeN mice
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information CD4+ T cell Mus musculus
-

Synonyms

Synonyms Comment Organism
MAP kinase
-
 Mus musculus
p38 mitogen-activated protein MAP kinase
-
 Mus musculus