Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | p38 expression and activity in signaling in erythroid cells is independent of erythropoietin | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation of p38alpha occurs in vivo only in absence of growth factor in primary erythroid progenitors | Homo sapiens | |
SB203580 | p38 isozyme alpha-specific inhibitor | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | p38 isozymes are involved in multiple cellular functions such as cell proliferation, cell differentiation, apoptosis, and inflammation response, p38 expression and activity in signaling in erythroid cells is independent of erythropoietin | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
four p38 isoforms alpha-delta | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | p38 isozymes are activated by phosphorylation through MAPK kinases MKK3, MKK6, and MAPKAP-2, EC 2.7.11.25, except for isozyme beta which is not activated by MKK3 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythroid cell | p38 isozymes alpha-delta expression patterns during erythroid differentiation of primary erythroid progenitors, isozymes alpha and gamma are expressed in early hematopoietic progenitors as well as in late differentiating erythroblasts, isozyme delta is only expressed and active during the terminal phase of erythroid differentiation, while isozyme beta is minimally expresses in early CD34+ hematopoietic progenitors | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein ATF2 | recombinant GST-tagged ATF2 substrate | Homo sapiens | ADP + phosphorylated protein ATF2 | - |
? | |
additional information | p38 isozymes are involved in multiple cellular functions such as cell proliferation, cell differentiation, apoptosis, and inflammation response, p38 expression and activity in signaling in erythroid cells is independent of erythropoietin | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAP kinase | - |
Homo sapiens |
MAPK | - |
Homo sapiens |
mitogen-activated protein kinase | - |
Homo sapiens |
p38 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |