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Literature summary for 2.7.11.24 extracted from

  • Samuvel, D.J.; Jayanthi, L.D.; Bhat, N.R.; Ramamoorthy, S.
    A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression (2005), J. Neurosci., 25, 29-41.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
beta-phorbol-13-acetate stimulates SERT phosphorylation Rattus norvegicus
D-amphetamine stimulates SERT phosphorylation Rattus norvegicus
additional information p38 MAPK needs to be activated by phosphorylation Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression of p38 MAPK in HEK293 cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
PD169316 i.e. 4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole, a specific p38 MAPK inhibitor, reduces 5-hydroxytryptamine uptake in cells, inhibits SERT phosphorylation Rattus norvegicus
SB203580 i.e. 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole, a specific p38 MAPK inhibitor, reduces 5-hydroxytryptamine uptake in cells, inhibits SERT phosphorylation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
synaptosome from midbrain Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus p38 MAPK, but not ERKs or JNKs, regulates the serotonin transporter, SERT, and subsequent signaling induced by 5-hydroxytryptamine, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein p38 MAPK needs to be activated by phosphorylation Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
purification of synaptosomes Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information p38 MAPK, but not ERKs or JNKs, regulates the serotonin transporter, SERT, and subsequent signaling induced by 5-hydroxytryptamine, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
p38 MAPK
-
 Rattus norvegicus
p38 mitogen-activated protein kinase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus