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Literature summary for 2.7.11.24 extracted from

  • Shimo, T.; Koyama, E.; Sugito, H.; Wu, C.; Shimo, S.; Pacifici, M.
    Retinoid signaling regulates CTGF expression in hypertrophic chondrocytes with differential involvement of MAP kinases (2005), J. Bone Miner. Res., 20, 867-877.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
PD98059 ERK1/2 inhibitor Gallus gallus
SB203580 p38 MAPK inhibitor Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Gallus gallus p38 MAPK, ERK1, and ERK2 are involved in regulation of connective tissue growth factor, CTGF, in chondrocyte maturation and function, particularly in the hypertrophic zone, as part of the retinoid and BMP signaling pathways, overview, p38 MAPK stimulates CTGF expression, while ERK1 and ERK2 supress it ?
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Organism

Organism UniProt Comment Textmining
Gallus gallus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
chondrocyte
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 Gallus gallus
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embryo
-
 Gallus gallus
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sternum embryonic Gallus gallus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information p38 MAPK, ERK1, and ERK2 are involved in regulation of connective tissue growth factor, CTGF, in chondrocyte maturation and function, particularly in the hypertrophic zone, as part of the retinoid and BMP signaling pathways, overview, p38 MAPK stimulates CTGF expression, while ERK1 and ERK2 supress it Gallus gallus ?
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 ?

Synonyms

Synonyms Comment Organism
ERK1
-
 Gallus gallus
ERK2
-
 Gallus gallus
MAP kinase
-
 Gallus gallus