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Literature summary for 2.7.11.24 extracted from

  • Sigoillot, F.D.; Kotsis, D.H.; Serre, V.; Sigoillot, S.M.; Evans, D.R.; Guy, H.I.
    Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD (2005), J. Biol. Chem., 280, 25611-25620.
    View publication on PubMed
Search for more literature for 2.7.11.24

Inhibitors

Inhibitors Comment Organism Structure
additional information PD 98059 inhibits EGF-induced nuclear translocation of CAD Homo sapiens
additional information PD98059 inhibits EGF-induced nuclear translocation of multifunctional protein CAD Mesocricetus auratus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information CAD occurs in the cytoplasm and the nucleus, but is phosphorylated only in the nucleus, CAD translocation is induced by EGF stimulation Homo sapiens
-
-
additional information multifunctional protein CAD occurs in the cytoplasm and the nucleus, but is phosphorylated only in the nucleus, CAD translocation is induced by EGF stimulation Mesocricetus auratus
-
-
nuclear matrix
-
 Homo sapiens 16363
-
nuclear matrix
-
 Mesocricetus auratus 16363
-
nucleus
-
 Homo sapiens 5634
-
nucleus
-
 Mesocricetus auratus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens
Mg2+
-
 Mesocricetus auratus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + multifunctional protein CAD Homo sapiens CAD initiates and regulates de novo pyrimidine biosynthesis and is activated by phosphorylation at Thr456 by nuclear MAPKs, nuclear import of CAD is required for optimal cell growth ADP + phosphorylated multifunctional protein CAD
-
 ?
ATP + multifunctional protein CAD Mesocricetus auratus CAD initiates and regulates de novo pyrimidine biosynthesis and is activated by phosphorylation at Thr456 by nuclear MAPKs, nuclear import of CAD is required for optimal cell growth ADP + phosphorylated multifunctional protein CAD
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mesocricetus auratus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
293 cell
-
 Homo sapiens
-
BHK-21 cell
-
 Mesocricetus auratus
-
breast
-
 Homo sapiens
-
breast cancer cell
-
 Homo sapiens
-
embryonic kidney cell line
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
kidney
-
 Mesocricetus auratus
-
MCF-10A cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
mesothelioma cell
-
 Homo sapiens
-
MSTO-211H cell mesothelioma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + multifunctional protein CAD CAD initiates and regulates de novo pyrimidine biosynthesis and is activated by phosphorylation at Thr456 by nuclear MAPKs, nuclear import of CAD is required for optimal cell growth Homo sapiens ADP + phosphorylated multifunctional protein CAD
-
 ?
ATP + multifunctional protein CAD CAD initiates and regulates de novo pyrimidine biosynthesis and is activated by phosphorylation at Thr456 by nuclear MAPKs, nuclear import of CAD is required for optimal cell growth Mesocricetus auratus ADP + phosphorylated multifunctional protein CAD
-
 ?
ATP + multifunctional protein CAD phosphorylation at Thr456, native and recombinant CAD Homo sapiens ADP + phosphorylated multifunctional protein CAD
-
 ?
ATP + multifunctional protein CAD phosphorylation at Thr456, native and recombinant multifunctional protein CAD Mesocricetus auratus ADP + phosphorylated multifunctional protein CAD
-
 ?

Synonyms

Synonyms Comment Organism
MAP kinase
-
 Homo sapiens
MAP kinase
-
 Mesocricetus auratus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
ATP
-
 Mesocricetus auratus