Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | tert-butyl hydroperoxide, causing oxidative stress incells, induces activation of ERK and p38 MAP kinase by increased phosphorylation, MAPKs are activated in response to intracellular reactive species, MAPK signaling cascade activation mechanism, overview | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PD98059 | inhibits ERK1 and ERK2 | Rattus norvegicus | |
SB203580 | inhibits p38 MAP kinase | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
x * 44000, ERK1, SDS-PAGE, x * 42000, ERK2, SDS-PAGE | Rattus norvegicus |
44000 | - |
x * 44000, ERK1, SDS-PAGE, x * 42000, ERK2, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | tert-butyl hydroperoxide activation of MAPK might be involved in vascular dysfunction in oxidative stress responses and the vascular inflammatory process | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | ERK1 and ERK2 are activated by phosphorylation at Thr and Tyr residues, p38 MAPK is activated by phosphorylation at Thr180 and Tyr182 | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelium | prostate endothelial cells | Rattus norvegicus | - |
prostate gland | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | tert-butyl hydroperoxide activation of MAPK might be involved in vascular dysfunction in oxidative stress responses and the vascular inflammatory process | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 44000, ERK1, SDS-PAGE, x * 42000, ERK2, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
ERK1 | - |
Rattus norvegicus |
ERK2 | - |
Rattus norvegicus |
extracellular-regulated kinase | - |
Rattus norvegicus |
JNK | - |
Rattus norvegicus |
MAP kinase | - |
Rattus norvegicus |
p38 MAP kinase | - |
Rattus norvegicus |
SAPK | - |
Rattus norvegicus |
stress-activated protein kinase | - |
Rattus norvegicus |