Literature summary for 2.7.11.24 extracted from

Ratner, A.J.; Bryan, R.; Weber, A.; Nguyen, S.; Barnes, D.; Pitt, A.; Gelber, S.; Cheung, A.; Prince, A.
Cystic fibrosis pathogens activate Ca2+-dependent mitogen-activated protein kinases signaling pathways in airway epithelial cells (2001), J. Biol. Chem., 276, 19267-19275.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	activation of the Ca2+-dependent signaling and expression of interleukin-8 in 1HAEo cells by EGTA at 1 mM and NiCl2 at 5-500 nM	Homo sapiens
thapsigargin	stimulates 4-5fold the expression of p44/p42	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	inhibition of the Ca2+-dependent signaling and expression of interleukin-8 in 1HAEo cells by BAPTA/AM, verapamil, cyclosporin A, FK-506, and TEMPO, and by an anti-asialoGM1 receptor antibody	Homo sapiens
PD98059	specific p42/44 mitogen-activated protein (MAP) kinase cascade inhibitor	Homo sapiens
SB202	p38 inhibitor SB202	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	the enzyme is part of a signalling cascade resulting in an increase in Ca2+-fluxes, activation of NF-kappaB, and expression of interleukin-8, the cascade is stimulated by pathogens, e.g. Pseudomonas aeruginosa PAO1 and Staphylococcus aureus RN6390, binding to asialo-glycolipid receptors, e.g. the asialoGM1 receptor, in epithelial membranes, no activation occurs with the pil mutant of Pseudomonas aeruginosa and the agr mutant of Staphylococcus aureus RN6911, Ca2+-dependent signaling, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	the mitogen-activated protein kinases are regulated by reversible phosphorylation	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
1HAEo cell	SV40 immortalized airway epithelial cell	Homo sapiens	-
cell culture	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is part of a signalling cascade resulting in an increase in Ca2+-fluxes, activation of NF-kappaB, and expression of interleukin-8, the cascade is stimulated by pathogens, e.g. Pseudomonas aeruginosa PAO1 and Staphylococcus aureus RN6390, binding to asialo-glycolipid receptors, e.g. the asialoGM1 receptor, in epithelial membranes, no activation occurs with the pil mutant of Pseudomonas aeruginosa and the agr mutant of Staphylococcus aureus RN6911, Ca2+-dependent signaling, overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
ERK1	-	Homo sapiens
ERK2	-	Homo sapiens
MAPK	-	Homo sapiens
p38	-	Homo sapiens
p42	-	Homo sapiens
p44	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)