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Literature summary for 2.7.11.24 extracted from

  • Kemp, B.E.; Pearson, R.B.; House, M.
    Pseudosubstrate-based peptide inhibitors (1991), Methods Enzymol., 201, 287-304.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(hydroxy-2-naphthalenylmethyl)phosphonic acid inhibits the insulin receptor tyrosine kinase, IC50 is 0.01 mM eukaryota
additional information synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential eukaryota

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
eukaryota

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein eukaryota
-
ADP + a phosphoprotein
-
?

Organism

Organism UniProt Comment Textmining
eukaryota
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein autophosphorylation near the pseudosubstrate site eukaryota

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
eukaryota ADP + a phosphoprotein
-
?
additional information substrate specificity eukaryota ?
-
?

Synonyms

Synonyms Comment Organism
receptor-linked ribosomal protein S6
-
eukaryota

Cofactor

Cofactor Comment Organism Structure
ATP
-
eukaryota

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information Ki values of the pseudosubstrates in nano- to micromolar range eukaryota

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.01
-
inhibits the insulin receptor tyrosine kinase, IC50 is 0.01 mM eukaryota (hydroxy-2-naphthalenylmethyl)phosphonic acid