KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.03 | - |
ATP | 30°C, pH 7.9, kinase CTDK1 | Homo sapiens | |
0.06 | - |
ATP | 30°C, pH 7.9, kinase CTDK2 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] | Homo sapiens | - |
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial | Homo sapiens |
two kinases: CDTK1 and CDTK2 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + casein | phosphorylated at about 30% the rate of RNA-polymerase II subunit | Homo sapiens | ADP + phosphocasein | - |
? | |
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] | - |
Homo sapiens | ADP + phospho-[DNA-directed RNA polymerase II subunit IIa] | - |
? | |
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] | kinase CTDK1: 33 mol phosphate per mol IIA-subunit | Homo sapiens | ADP + phospho-[DNA-directed RNA polymerase II subunit IIa] | - |
? | |
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] | kinase CTDK1 almost exclusively phosphorylates Ser-residues | Homo sapiens | ADP + phospho-[DNA-directed RNA polymerase II subunit IIa] | - |
? | |
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] | kinase CTDK2: 40-50 mol phosphate per mol IIA-subunit, i.e. 1 phosphate per heptapeptide repeat | Homo sapiens | ADP + phospho-[DNA-directed RNA polymerase II subunit IIa] | - |
? | |
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] | phosphorylates predominantly Ser-residues | Homo sapiens | ADP + phospho-[DNA-directed RNA polymerase II subunit IIa] | - |
? | |
dATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] | - |
Homo sapiens | dADP + ? | - |
? | |
GTP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] | kinase CTDK1, not kinase CTDK2 | Homo sapiens | GDP + ? | - |
? |