Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + polymerase II C-terminal domain | Homo sapiens | - |
ADP + phosphorylated polymerase II C-terminal domain | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q14004 | - |
- |
Homo sapiens | Q9NYV4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HCT-116 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + polymerase II C-terminal domain | - |
Homo sapiens | ADP + phosphorylated polymerase II C-terminal domain | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CDK12 | isoform | Homo sapiens |
CDK13 | isoform | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | isoform CDK12 depletion leads to a loss of expression of RNA processing factors and to defects in RNA processing | Homo sapiens |
malfunction | isoform CDK13 depletion leads to a loss of expression of RNA processing factors and to defects in RNA processing | Homo sapiens |
physiological function | isoform CDK12 affects RNA processing through direct physical interactions with RNA processing factors and by regulating their expression | Homo sapiens |
physiological function | isoform CDK13 affect RNA processing through direct physical interactions with RNA processing factors and by regulating their expression | Homo sapiens |