Literature summary for 2.7.11.22 extracted from

Albert, T.K.; Rigault, C.; Eickhoff, J.; Baumgart, K.; Antrecht, C.; Klebl, B.; Mittler, G.; Meisterernst, M.
Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor (2014), Br. J. Pharmacol., 171, 55-68.

Search for more literature for 2.7.11.22

Inhibitors

Inhibitors	Comment	Organism	Structure
5,6-dichloro-1-beta-D-ribofuranosyl-benzimidazole	-	Homo sapiens
flavopiridol	-	Homo sapiens
LDC000067	highly specific inhibitor for isoform CDK9, i.e. 3-((6-(2-methoxyphenyl)pyrimidin-4-yl)aminophenyl)methane sulfonamide	Homo sapiens
SNS-032	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + a protein	Homo sapiens	-	ADP + phosphorylated protein	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
HCT-116 cell	-	Homo sapiens	-
HeLa cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
THP-1 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + a protein	-	Homo sapiens	ADP + phosphorylated protein	-	?

Synonyms

Synonyms	Comment	Organism
CDK9	isoform	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000014	-	isoform CDK9, at pH 7.5 and 37°C	Homo sapiens	SNS-032
0.0000052	-	isoform CDK9, at pH 7.5 and 37°C	Homo sapiens	flavopiridol
0.000044	-	isoform CDK9, at pH 7.5 and 37°C	Homo sapiens	LDC000067
0.001942	-	isoform CDK9, at pH 7.5 and 37°C	Homo sapiens	5,6-dichloro-1-beta-D-ribofuranosyl-benzimidazole

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)