Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cyclin B | activates CDKA | Physcomitrium patens | |
additional information | poor activation of CDKA with cyclin D | Physcomitrium patens |
Cloned (Comment) | Organism |
---|---|
expression of tagged isozyme CDKA;1 as inducible enzyme in wild-type Physcomitrella patens | Physcomitrium patens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Physcomitrium patens | - |
isozymes CDKA;1, and CDKA;2 | - |
Physcomitrium patens Gransden-2004 | - |
isozymes CDKA;1, and CDKA;2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gametophore | gametophore leaf cell | Physcomitrium patens | - |
leaf | - |
Physcomitrium patens | - |
Synonyms | Comment | Organism |
---|---|---|
CDKA | - |
Physcomitrium patens |
cyclin-dependent kinase A | - |
Physcomitrium patens |
General Information | Comment | Organism |
---|---|---|
malfunction | treatment of leaf cells with a CDK inhibitor or induction of dominant-negative CDKA1 protein inhibits not only cell cycle progression but also tip growth and protonemal gene expression | Physcomitrium patens |
metabolism | activity of cyclin-dependent kinase A links cell cycle reactivation and the acquisition of new cell-type characteristics during reprogramming in the moss Physcomitrella patens, overview. Cell cycle progression is not required for acquisition of protonema cell-type characteristics | Physcomitrium patens |
physiological function | the activity of cyclin-dependent kinase A links cell cycle reactivation and the acquisition of new cell-type characteristics during reprogramming in the moss Physcomitrella patens, overview. Leaf cells facing the cut undergo CDK activation along with induction of a D-type cyclin, tip growth, and transcriptional activation of protonema-specific genes, CDKA regulates protonema-specific genes and tip growth, as well as cell cycle progression and other cellular changes in parallel. But iozymes CDKA;1 and CDKA;2 are expressed before cutting and activated afterwards | Physcomitrium patens |