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Literature summary for 2.7.11.22 extracted from
- Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases (2011), J. Biol. Chem., 286, 16647-16657.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cyclin B | required for CDK1 activity | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| p27 | a CDK inhibitor | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + early mitotic inhibitor 1 protein | Homo sapiens | i.e. Emi1, is phosphorylated by CDKs in mitotic but not S-phase cell extracts | ADP + early mitotic inhibitor 1 phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa-S3 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + early mitotic inhibitor 1 protein | - |
Homo sapiens | ADP + early mitotic inhibitor 1 phosphoprotein | - |
? | |
| ATP + early mitotic inhibitor 1 protein | i.e. Emi1, is phosphorylated by CDKs in mitotic but not S-phase cell extracts | Homo sapiens | ADP + early mitotic inhibitor 1 phosphoprotein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CDK | - |
Homo sapiens |
| Cdk1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | 7.6 | assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | cell cycle regulation is characterized by alternating activities of cyclin-dependent kinases and of the ubiquitin ligase anaphase promoting complex/cyclosome, overview. The latter is inhibited during S-phase by early mitotic inhibitor 1, which is negatively regulated by phosphorylation through CDKs, allowing the accumulation of cyclins A and B and to prevent re-replication, overview | Homo sapiens |
| physiological function | CDK-mediated phosphorylation of early mitotic inhibitor 1 prevents its binding to ubiquitin ligase anaphase promoting complex/cyclosome | Homo sapiens |
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