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Literature summary for 2.7.11.22 extracted from
- Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition (2010), Endocrinology, 151, 896-908.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cyclin E | required for activity | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of GFP- and Myc-tagged CDK2 in 293 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | generation of human prostate cancer cells that are resistant to growth inhibition by 1,25-dihydroxyvitamin D3 but retain fully functional vitaminD receptors. These cells do not exhibit 1,25-dihydroxyvitamin D3-mediated cytoplasmic relocalization of CDK2 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,25-dihydroxyvitamin D3 | inhibition of CDK2 activity by 1,25-dihydroxyvitamin D3 is associated with decreased T160 phosphorylation, a residue whose phosphorylation in the nucleus is essential for CDK2 activity. 1,25-dihydroxyvitamin D3 increases the stability of the cyclin-dependent kinase inhibitor p27KIP1. Ectopic expression of cyclin E is sufficient to overcome 1,25-dihydroxyvitamin D3-mediated cytoplasmic mislocalization of CDK2 and all antiproliferative effects of 1,25-dihydroxyvitamin D3, yet endogenous levels of cyclin E or binding to CDK2 are not affected by 1,25-dihydroxyvitamin D3. Targeting CDK2 to the nucleus of 1,25-dihydroxyvitamin D3-sensitive cancer cells blocked G1 accumulation and growth inhibition by 1,25-dihydroxyvitamin D3 | Homo sapiens |  |
| cyclin-dependent kinase inhibitor p27KIP1 | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| additional information | CDK2 nuclear-cytoplasmic trafficking | Homo sapiens | - |
- |
| nucleus | - |
Homo sapiens | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | T160 phosphorylation in the nucleus is essential for CDK2 activity | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| LNCaP cell | - |
Homo sapiens | - |
| prostate cancer cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CDK2 | - |
Homo sapiens |
| cyclin-dependent kinase 2 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 3 | - |
assay at | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | role of CDK2 cytoplasmic relocalization in the antiproliferative effects of 1,25-dihydroxyvitamin D3. Central roles for CDK2 nuclear-cytoplasmic trafficking and cyclin E in the mechanism of 1,25-dihydroxyvitamin D3-mediated growth inhibition in prostate cancer cells | Homo sapiens |
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