Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cyclin H | activates Cdk7 | Homo sapiens | |
cyclin T1 | activates Cdk9 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-roscovitine | - |
Homo sapiens | |
5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole | specific CDK7 and 9 inhibition drives resolution of neutrophil-dominant inflammation | Homo sapiens | |
p21v1 | endogenous CDK inhibitor | Homo sapiens | |
p21v2 | endogenous CDK inhibitor | Homo sapiens | |
p27 | endogenous CDK inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RNA polymerase II C-terminal domain | Homo sapiens | phosphorylation by Cdk7 and Cdk9, phosphorylation at serine residues 2 and 5 | ADP + phosphorylated RNA polymerase II C-terminal domain | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RNA polymerase II C-terminal domain | phosphorylation by Cdk7 and Cdk9, phosphorylation at serine residues 2 and 5 | Homo sapiens | ADP + phosphorylated RNA polymerase II C-terminal domain | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cdk7 | - |
Homo sapiens |
CDK9 | - |
Homo sapiens |
cyclin-dependent kinases 7 | - |
Homo sapiens |
cyclin-dependent kinases 9 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of cyclin-dependent kinases 7 and 9 drives apoptosis to promote resolution of inflammation, CDK and protein synthesis inhibitors induce neutrophil apoptosis, overview. Cdk inhibitor R-roscovitine affects global gene transcription in LPS-stimulated and -unstimulated primary human neutrophils, overview | Homo sapiens |
metabolism | cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription | Homo sapiens |
physiological function | cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription, overview | Homo sapiens |