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Literature summary for 2.7.11.22 extracted from

  • Leitch, A.E.; Lucas, C.D.; Marwick, J.A.; Duffin, R.; Haslett, C.; Rossi, A.G.
    Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation (2012), Cell Death Differ., 19, 1950-1961.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
cyclin H activates Cdk7 Homo sapiens
cyclin T1 activates Cdk9 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(R)-roscovitine
-
Homo sapiens
5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole specific CDK7 and 9 inhibition drives resolution of neutrophil-dominant inflammation Homo sapiens
p21v1 endogenous CDK inhibitor Homo sapiens
p21v2 endogenous CDK inhibitor Homo sapiens
p27 endogenous CDK inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + RNA polymerase II C-terminal domain Homo sapiens phosphorylation by Cdk7 and Cdk9, phosphorylation at serine residues 2 and 5 ADP + phosphorylated RNA polymerase II C-terminal domain
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RNA polymerase II C-terminal domain phosphorylation by Cdk7 and Cdk9, phosphorylation at serine residues 2 and 5 Homo sapiens ADP + phosphorylated RNA polymerase II C-terminal domain
-
?

Synonyms

Synonyms Comment Organism
cdk7
-
Homo sapiens
CDK9
-
Homo sapiens
cyclin-dependent kinases 7
-
Homo sapiens
cyclin-dependent kinases 9
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
malfunction inhibition of cyclin-dependent kinases 7 and 9 drives apoptosis to promote resolution of inflammation, CDK and protein synthesis inhibitors induce neutrophil apoptosis, overview. Cdk inhibitor R-roscovitine affects global gene transcription in LPS-stimulated and -unstimulated primary human neutrophils, overview Homo sapiens
metabolism cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription Homo sapiens
physiological function cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription, overview Homo sapiens