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Literature summary for 2.7.11.22 extracted from

  • Bartova, I.; Koca, J.; Otyepka, M.
    Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation (2008), Protein Sci., 17, 22-33.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information full activation of CDK2 requires both binding of cyclin A or cyclin E and phosphorylation of residue T160 in the activation segment (also known as the T-loop) by the CDK-activating kinase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P24941
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H1
-
 Homo sapiens ADP + phosphorylated histone H1
-
 ?

Synonyms

Synonyms Comment Organism
CDK2
-
 Homo sapiens
cyclin-dependent kinase-2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
cyclin A full activation of CDK2 requires both binding of cyclin A or cyclin E and phosphorylation of residue T160 in the activation segment (also known as the T-loop) by the CDK-activating kinase Homo sapiens
cyclin E full activation of CDK2 requires both binding of cyclin A or cyclin E and phosphorylation of residue T160 in the activation segment (also known as the T-loop) by the CDK-activating kinase Homo sapiens