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Literature summary for 2.7.11.22 extracted from

  • Hsiao, Y.H.; Chen, P.S.; Yeh, S.H.; Lin, C.H.; Gean, P.W.
    N-acetylcysteine prevents beta-amyloid toxicity by a stimulatory effect on p35/cyclin-dependent kinase 5 activity in cultured cortical neurons (2008), J. Neurosci. Res., 86, 2685-2695.
    View publication on PubMed
Search for more literature for 2.7.11.22

Activating Compound

Activating Compound Comment Organism Structure
N-acetylcysteine 10 mM, increases cyclin-dependent kinase 5 phosphorylation, phosphorylation of Cdk5 on tyrosine 15 by c-Abl increases kinase activity of the p35/Cdk5 complex Rattus norvegicus
p35 monomeric Cdk5 has no enzymatic activity and requires association with a regulatory binding partner p35 for its activation Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Butyrolactone 0.01 mM Rattus norvegicus
roscovitine 0.015 mM Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortical neuron
-
 Rattus norvegicus
-
primary culture
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H1
-
 Rattus norvegicus ADP + phosphorylated histone H1
-
 ?

Synonyms

Synonyms Comment Organism
Cdk5
-
 Rattus norvegicus
cyclin-dependent kinase 5
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
cyclin dependent on Rattus norvegicus