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Literature summary for 2.7.11.22 extracted from
- Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2 (2008), J. Neurosci., 28, 4872-4877.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| p35 | activation of Cdk5 requires association with two noncyclin neural-specific activators p35 and p39 | Mus musculus | |
| p39 | activation of Cdk5 requires association with two noncyclin neural-specific activators p35 and p39 | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neuron | - |
Mus musculus | - |
| retina | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + B-cell lymphoma protein 2 | B-cell lymphoma protein 2 is phosphorylated at Ser70, Cdk5-mediated B-cell lymphoma protein 2 phosphorylation is pivotal for the antiapoptotic effect of Bcl-2 and contributes to the maintenance of neuronal survival by Cdk5 | Mus musculus | ADP + phosphorylated B-cell lymphoma protein 2 | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cdk5 | - |
Mus musculus |
| cyclin-dependent kinase 5 | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cyclin | - |
Mus musculus |
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Release 2023.1 (January 2023)
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