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Literature summary for 2.7.11.22 extracted from
- Dopaminergic and glutamatergic signaling crosstalk in Huntingtons disease neurodegeneration: the role of p25/cyclin-dependent kinase 5 (2008), J. Neurosci., 28, 10090-10101.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| p35 | - |
Mus musculus | |
| p35 | - |
Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the p25/Cdk5 complex is an important mediator of dopamine and glutamate neurotoxicity associated to Huntigton's disease | Mus musculus |
| medicine | the p25/Cdk5 complex is an important mediator of dopamine and glutamate neurotoxicity associated to Huntigton's disease | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| roscovitine | 0.02 mM, potent Cdk5 inhibitor | Homo sapiens |  |
| roscovitine | 0.02 mM, potent Cdk5 inhibitor | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q00535 | - |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| corpus striatum | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histone 1 | - |
Mus musculus | ADP + phosphorylated histone 1 | - |
? | |
| ATP + histone 1 | - |
Homo sapiens | ADP + phosphorylated histone 1 | - |
? | |
| ATP + huntingtin | - |
Mus musculus | ADP + phosphorylated huntingtin | - |
? | |
| ATP + huntingtin | - |
Homo sapiens | ADP + phosphorylated huntingtin | - |
? | |
| ATP + tau protein | - |
Mus musculus | ADP + phosphorylated tau protein | - |
? | |
| ATP + tau protein | - |
Homo sapiens | ADP + phosphorylated tau protein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cdk5 | - |
Mus musculus |
| Cdk5 | - |
Homo sapiens |
| cyclin-dependent kinase 5 | - |
Mus musculus |
| cyclin-dependent kinase 5 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cyclin | - |
Mus musculus | |
| cyclin | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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