Literature summary for 2.7.11.22 extracted from

Liu, M.; Choi, S.; Cuny, G.D.; Ding, K.; Dobson, B.C.; Glicksman, M.A.; Auerbach, K.; Stein, R.L.
Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors (2008), Biochemistry, 47, 8367-8377.

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Activating Compound

Activating Compound	Comment	Organism	Structure
p25	-	Homo sapiens

Application

Application	Comment	Organism
medicine	causal role in Alzheimer's disease	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
1-(5-cyclobutyl-thiazol-2-yl)-3-isoquinolin-5-yl-urea	competitive inhibitor	Homo sapiens
AMP	competitive inhibitor	Homo sapiens
H1PAla	noncompetitive inhibitor	Homo sapiens
H1PPO4	noncompetitive inhibitor	Homo sapiens
N4-(6-aminopyrimidin-4-yl)-sulfanilamide	competitive inhibitor	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.017	-	ATP	in 20 mM MOPS (pH 7.5), at 30°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + histone H1-derived peptide	-	Homo sapiens	ADP + histone H1-derived peptide phosphate	-	?
ATP + protein tau	-	Homo sapiens	ADP + protein tau phosphate	-	?

Synonyms

Synonyms	Comment	Organism
cdk5/p25 kinase	-	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.28	-	ATP	in 20 mM MOPS (pH 7.5), at 30°C	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens
cyclin	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0036	-	in 20 mM MOPS (pH 7.5), at 30°C	Homo sapiens	N4-(6-aminopyrimidin-4-yl)-sulfanilamide

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Release 2023.1 (January 2023)