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Literature summary for 2.7.11.22 extracted from

  • Pareek, T.K.; Keller, J.; Kesavapany, S.; Pant, H.C.; Iadarola, M.J.; Brady, R.O.; Kulkarni, A.B.
    Cyclin-dependent kinase 5 activity regulates pain signaling (2006), Proc. Natl. Acad. Sci. USA, 103, 791-796.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.22

Activating Compound

Activating Compound Comment Organism Structure
additional information inflammation increases Cdk5 activity Rattus norvegicus
p25 increased calpain activity in sensory neurons after inflammation results in the cleavage of p35 to p25, which forms a more stable complex with Cdk5 and, consequently, leads to elevation of Cdk5 activity Rattus norvegicus
p35
-
 Rattus norvegicus
p35 p35 knockout mice (p35-/-), which exhibit significantly decreased Cdk5 activity, show delayed responses to painful thermal stimulation compared with wild-type controls. In contrast, mice overexpressing p35, which exhibit elevated levels of Cdk5 activity, are more sensitive to painful thermal stimuli than are controls Mus musculus

Application

Application Comment Organism
medicine role for Cdk5/p35 activity in primary afferent nociceptive signaling, Cdk5/p35 may be a target for the development of analgesic drugs Mus musculus
medicine role for Cdk5/p35 activity in primary afferent nociceptive signaling, Cdk5/p35 may be a target for the development of analgesic drugs Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
roscovitine
-
 Mus musculus
roscovitine
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL6/129SVJ and FVBN wild-type mice
-
Rattus norvegicus
-
 Sprague–Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
-
embryo
-
 Rattus norvegicus
-
ganglion dorsal root ganglia Rattus norvegicus
-
ganglion dorsal root ganglia and trigeminal ganglia, Cdk5 is colocalized with p35 Mus musculus
-
neuron nociceptive neuron Mus musculus
-
neuron nociceptive neuron Rattus norvegicus
-
spinal cord
-
 Rattus norvegicus
-
spinal cord Cdk5 is colocalized with p35 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H1
-
 Mus musculus ADP + phosphorylated histone H1
-
 ?
ATP + histone H1
-
 Rattus norvegicus ADP + phosphorylated histone H1
-
 ?
ATP + NF-H peptide
-
 Rattus norvegicus ADP + phosphorylated NF-H peptide
-
 ?

Synonyms

Synonyms Comment Organism
Cdk5
-
 Mus musculus
Cdk5
-
 Rattus norvegicus
cyclin-dependent kinase 5
-
 Mus musculus
cyclin-dependent kinase 5
-
 Rattus norvegicus