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Literature summary for 2.7.11.22 extracted from
- Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activity (2007), Mol. Cancer Ther., 6, 2168-2177.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transfection of the erlotinib-sensitive A-431, SK-BR-3, and BT-474 cells with wild-type CDK2, restoration of CDK2 activity and partially restoration of cell proliferation | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| DN-CDK2 | suppresses CDK2 activity and partially increases erlotinib sensitivity | Homo sapiens | |
| erlotinib | erlotinib treatment of breast cancer cells suppresses CDK2 activity; suppresses CDK2 activity, which is critical for cellular sensitivity to erlotinib, regardless of EGFR expression level. CDK1, CDK4 and CDK6 is not associated with erlotinib sensitivity | Homo sapiens |  |
| p27 | - |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | P24941 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| protein G/protein A-agarose bead chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-431 cell | - |
Homo sapiens | - |
| breast cancer cell | - |
Homo sapiens | - |
| breast carcinoma cell line | - |
Homo sapiens | - |
| BT-20 cell | - |
Homo sapiens | - |
| BT-474 cell | - |
Homo sapiens | - |
| epidermoid carcinoma cell | - |
Homo sapiens | - |
| MCF-7 cell | - |
Homo sapiens | - |
| MDA-MB-231 cell | - |
Homo sapiens | - |
| MDA-MB-361 cell | - |
Homo sapiens | - |
| MDA-MB-435 cell | - |
Homo sapiens | - |
| MDA-MB-453 cell | - |
Homo sapiens | - |
| MDA-MB-468 cell | - |
Homo sapiens | - |
| additional information | epidermoid carcinoma cell line | Homo sapiens | - |
| SK-BR-3 cell | - |
Homo sapiens | - |
| T-47D cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histone H1 | - |
Homo sapiens | ADP + phosphorylated histone H1 | - |
? | |
| ATP + histone H1 | CDK2 | Homo sapiens | ADP + phosphorylated histone H1 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cdk1 | - |
Homo sapiens |
| CDK2 | - |
Homo sapiens |
| CDK4 | - |
Homo sapiens |
| cdk6 | - |
Homo sapiens |
| cyclin-dependent kinase 2 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cyclin | - |
Homo sapiens |
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