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Literature summary for 2.7.11.22 extracted from

  • Ikui, A.E.; Archambault, V.; Drapkin, B.J.; Campbell, V.; Cross, F.R.
    Cyclin and cyclin-dependent kinase substrate requirements for preventing rereplication reveal the need for concomitant activation and inhibition (2007), Genetics, 175, 1011-1022.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.22

Activating Compound

Activating Compound Comment Organism Structure
cyclin different B-type cyclins are substantially redundant for rereplication control by multiple mechanisms. S-phase cyclin Clb5 and the mitotic cyclins Clb1-4 are inferred to be capable of imposing ORC-based and MCM-based controls. S-phase cyclin Clb6 can promote initiation of replication without blocking reinitiation, activity is highly toxic when the ability of other cyclins to block reinitiation is prevented by mutation Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Cdc6
-
 Saccharomyces cerevisiae ADP + phosphorylated Cdc6
-
 ?
ATP + mini-chromosomemaintenance protein 2
-
 Saccharomyces cerevisiae ADP + phosphorylated mini-chromosomemaintenance protein 2
-
 ?
ATP + mini-chromosomemaintenance protein 3
-
 Saccharomyces cerevisiae ADP + phosphorylated mini-chromosomemaintenance protein 3
-
 ?
ATP + mini-chromosomemaintenance protein 4
-
 Saccharomyces cerevisiae ADP + phosphorylated mini-chromosomemaintenance protein 4
-
 ?
ATP + mini-chromosomemaintenance protein 5
-
 Saccharomyces cerevisiae ADP + phosphorylated mini-chromosomemaintenance protein 5
-
 ?
ATP + mini-chromosomemaintenance protein 6
-
 Saccharomyces cerevisiae ADP + phosphorylated mini-chromosomemaintenance protein 6
-
 ?
ATP + mini-chromosomemaintenance protein 7
-
 Saccharomyces cerevisiae ADP + phosphorylated mini-chromosomemaintenance protein 7
-
 ?
ATP + origin recognition complex 1
-
 Saccharomyces cerevisiae ADP + phosphorylated origin recognition complex 1
-
 ?
ATP + origin recognition complex 2
-
 Saccharomyces cerevisiae ADP + phosphorylated origin recognition complex 2
-
 ?
ATP + origin recognition complex 3
-
 Saccharomyces cerevisiae ADP + phosphorylated origin recognition complex 3
-
 ?
ATP + origin recognition complex 4
-
 Saccharomyces cerevisiae ADP + phosphorylated origin recognition complex 4
-
 ?
ATP + origin recognition complex 5
-
 Saccharomyces cerevisiae ADP + phosphorylated origin recognition complex 5
-
 ?
ATP + origin recognition complex 6
-
 Saccharomyces cerevisiae ADP + phosphorylated origin recognition complex 6
-
 ?
additional information once-per-cell-cycle replication is enforced by cyclin-Cdk-dependent phosphorylation of the prereplicative complex components Mcm2-7, Cdc6, and Orc1-6 Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
B-type cyclin-dependent kinase
-
 Saccharomyces cerevisiae
CDK
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
cyclin Clb5
-
 Saccharomyces cerevisiae
cyclin Clb6
-
 Saccharomyces cerevisiae