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Literature summary for 2.7.11.22 extracted from

  • den Hollander, P.; Kumar, R.
    Dynein light chain 1 contributes to cell cycle progression by increasing cyclin-dependent kinase 2 activity in estrogen-stimulated cells (2006), Cancer Res., 66, 5941-5949.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dynein light chain 1 interacts with cdk2 and enhances Cdk2 kinase activity in vivo, dynein light chain 1 accelerates the G1-S transition by enhancing the activity of Cdk2 Homo sapiens

Application

Application Comment Organism
medicine interactions among Cdk2, dynein light chain 1, and cip-interacting zinc finger protein 1 play a regulatory role in cell cycle progression of cancer cells presumably by influencing the levels of nuclear p21WAF1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Ishikawa cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
ZR-75-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone 1
-
Homo sapiens ADP + phosphorylated histone 1
-
?

Synonyms

Synonyms Comment Organism
CDK2
-
Homo sapiens
cyclin-dependent kinase 2
-
Homo sapiens