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Literature summary for 2.7.11.22 extracted from
- Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta (2006), Biochemistry, 45, 3134-3145.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| p25 | primes tau protein for GSK3beta in vivo | Homo sapiens | |
| p35 | primes tau protein for GSK3beta in vivo | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| Cdk5 cDNA subcloned into pcDNA 3.1/HisA vector, HEK-293 cells cotransfected with tau protein, GSK3beta, and Cdk5 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Olomoucine | Cdk5 inhibitor, tau protein phosphorylation at S202, S235, and S404 is inhibited to a basal level | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microtubule | - |
Bos taurus | 5874 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 25000 | - |
immunoblot analysis | Bos taurus |
| 450000 | - |
complex of Cdk5, GSK3beta, and tau protein, gel filtration | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + tau protein | Homo sapiens | Cdk5 phosphorylates at S202, S235, and S404, phosphorylation at S235 primes it for phosphorylation of T231 by GSK3beta, phosphorylating tau protein at S404 primes tau protein for a sequential phosphorylation of S400 and S396 by GSK3beta | ADP + phosphorylated tau protein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Bos taurus | - |
| brain | is colocalized with tau protein and GSK3beta in brain cortex | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + tau protein | - |
Homo sapiens | ADP + phosphorylated tau protein | - |
? | |
| ATP + tau protein | - |
Rattus norvegicus | ADP + phosphorylated tau protein | - |
? | |
| ATP + tau protein | - |
Bos taurus | ADP + phosphorylated tau protein | - |
? | |
| ATP + tau protein | Cdk5 phosphorylates at S202, S235, and S404, phosphorylation at S235 primes it for phosphorylation of T231 by GSK3beta, phosphorylating tau protein at S404 primes tau protein for a sequential phosphorylation of S400 and S396 by GSK3beta | Homo sapiens | ADP + phosphorylated tau protein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cdk5 | - |
Homo sapiens |
| Cdk5 | - |
Rattus norvegicus |
| Cdk5 | - |
Bos taurus |
| cyclin-dependent protein kinase 5 | - |
Homo sapiens |
| cyclin-dependent protein kinase 5 | - |
Rattus norvegicus |
| cyclin-dependent protein kinase 5 | - |
Bos taurus |
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Release 2023.1 (January 2023)
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