Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | CDK is inhibited by phosphorylation through somatic Wee1A in M phase | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Wee1A | Homo sapiens | phosphorylation at S123, S53, and S121 promotes binding of Wee1A by beta-TrCP, the beta-transducin repeat-containing protein, which is the substrate recognition component of the ubiquitin ligase, leading to proteasomal degradation of Wee1A, overview | ADP + phosphorylated Wee1A | - |
? | |
additional information | Homo sapiens | the polo-kinase 1, EC 2.7.11.21, also phosphorylates Wee1A at S53 and S123, casein kinase II, EC 2.7.11.1, also phosphorylates Wee1A at S121 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | CDK is inhibited by phosphorylation through somatic Wee1A in M phase | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Wee1A | phosphorylation at S123, S53, and S121 promotes binding of Wee1A by beta-TrCP, the beta-transducin repeat-containing protein, which is the substrate recognition component of the ubiquitin ligase, leading to proteasomal degradation of Wee1A, overview | Homo sapiens | ADP + phosphorylated Wee1A | - |
? | |
ATP + Wee1A | phosphorylation at S123, S53, and S121 | Homo sapiens | ADP + phosphorylated Wee1A | - |
? | |
additional information | the polo-kinase 1, EC 2.7.11.21, also phosphorylates Wee1A at S53 and S123, casein kinase II, EC 2.7.11.1, also phosphorylates Wee1A at S121 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CDK | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
cyclin | regulatory subunit of the CDK | Homo sapiens |