BRENDA - Enzyme Database
show all sequences of 2.7.11.22

The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator

Hisanaga, S.; Saito, T.; Neurosignals 12, 221-229 (2003)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
p35
activation subunit, required, interacts with and activates Cdk5, laminin induces upregulation of p35, regulation of p35 expression, overview
Mus musculus
p35
activation subunit, required, interacts with and activates Cdk5, laminin induces upregulation of p35, regulation of p35 expression, overview
Homo sapiens
p35
activation subunit, required, interacts with and activates Cdk5, laminin induces upregulation of p35, regulation of p35 expression, overview
Rattus norvegicus
p39
activation subunit, can substitute for p35, interacts with and activates Cdk5
Mus musculus
p39
activation subunit, can substitute for p35, interacts with and activates Cdk5
Homo sapiens
p39
activation subunit, can substitute for p35, interacts with and activates Cdk5
Rattus norvegicus
Cloned(Commentary)
Cloned (Commentary)
Organism
regulation of p35 expression, overview
Mus musculus
regulation of p35 expression, overview
Homo sapiens
regulation of p35 expression, overview
Rattus norvegicus
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
glutamate triggers the ubiquitination and subsequent degradation of p35 in neurons after autophosphorylation of Cdk5-p35 at p35
Homo sapiens
additional information
glutamate triggers the ubiquitination and subsequent degradation of p35 in neurons after autophosphorylation of Cdk5-p35 at p35
Mus musculus
additional information
glutamate triggers the ubiquitination and subsequent degradation of p35 in neurons after autophosphorylation of Cdk5-p35 at p35
Rattus norvegicus
roscovitine
-
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoskeleton
Cdk5-p35
Mus musculus
5856
-
cytoskeleton
Cdk5-p35
Rattus norvegicus
5856
-
membrane
Cdk5-p35
Mus musculus
16020
-
membrane
Cdk5-p35
Rattus norvegicus
16020
-
additional information
Ca2+ induces cleavage of p35 to p25 by calpains, which changes the localization of Cdk5 from the particulate to the soluble fraction
Mus musculus
-
-
additional information
Ca2+ induces cleavage of p35 to p25 by calpains, which changes the localization of Cdk5 from the particulate to the soluble fraction
Rattus norvegicus
-
-
soluble
Cdk5-p25
Mus musculus
-
-
soluble
Cdk5-p25
Rattus norvegicus
-
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
induces cleavage of p35 to p25 by calpains, which changes the localization of Cdk5 from the particluate to the soluble fraction
Mus musculus
Ca2+
induces cleavage of p35 to p25 by calpains, which changes the localization of Cdk5 from the particulate to the soluble fraction
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ATP + tau protein
Mus musculus
cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35
ADP + phosphorylated tau protein
-
-
?
ATP + tau protein
Rattus norvegicus
cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35
ADP + phosphorylated tau protein
-
-
?
additional information
Homo sapiens
the CDKs are involved in regulation of cell cycle and neuronal differentiation
?
-
-
?
additional information
Mus musculus
the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia
?
-
-
?
additional information
Rattus norvegicus
the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia
?
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
additional information
p35 and cyclin B are ubiquitinated prior to degradation, proteasomal degradation of p35 is induced by phosphatase inhibitor okadaic acid, proteolytic patterns of p35 amd p39, overview
Mus musculus
additional information
p35 and cyclin B are ubiquitinated prior to degradation, proteasomal degradation of p35 is induced by phosphatase inhibitor okadaic acid, proteolytic patterns of p35 amd p39, overview
Homo sapiens
additional information
p35 and cyclin B are ubiquitinated prior to degradation, proteasomal degradation of p35 is induced by phosphatase inhibitor okadaic acid, proteolytic patterns of p35 amd p39, overview
Rattus norvegicus
phosphoprotein
in S/G2 phase of the cell cycle, Cdk1/Cdc2, upon binding of cyclin B, is phosphorylated and inactivated at T14, Y15, and T161 by protein kinases Wee1 and CAK, to activate the enzyme T14 and Y15 are dephosphorylated by phosphatase Cde25, the active enzyme is only phosphorylated at T161, release of cyclin B results in complete dephosphorylation of Cdk1/Cdc2, overview, Cdk5 binds p35 and is then activated by phosphorylation at T14, Y15, and S519, the bound p35 is also autophosphorylated by Cdk5-p35 at a single site, which induces ubiquitination and subsequent degradation of p35 in neurons, release of p35 leads to dephosphorylation of Cdk5, overview
Homo sapiens
phosphoprotein
in S/G2 phase of the cell cycle, Cdk1/Cdc2, upon binding of cyclin B, is phosphorylated and inactivated at T14, Y15, and T161 by protein kinases Wee1 and CAK, to activate the enzyme T14 and Y15 are dephosphorylated by phosphatase Cde25, the active enzyme is only phosphorylated at T161, release of cyclin B results in complete dephosphorylation of Cdk1/Cdc2, overview, Cdk5 binds p35 and is then activated by phosphorylation at T14, Y15, and S519, the bound p35 is also autophosphorylated by Cdk5-p35 at a single site, which induces ubiquitination and subsequent degradation of p35 in neurons, release of p35 leads to dephosphorylation of Cdk5, overview
Rattus norvegicus
phosphoprotein
in S/G2 phase of the cell cycle, Cdk1/Cdc2, upon binding of cyclin B, is phosphorylated and inactivated at T14, Y15, and T161 by protein kinases Wee1 and CAK, to activate the enzyme T14 and Y15 are dephosphorylated by phosphatase Cde25, the active enzyme is only phosphorylated at T161, release of cyclin B results in complete dephosphorylation of Cdk1/Cdc2, overview, Cdk5 binds p35 and is then activated by phosphorylation at T14, Y15, and S519, the bound p35 is also autophosphorylated by Cdk5-p35 at a single site, which induces ubiquitination and subsequent degradation of p35 in neurons, release of p35 leads to dephosphorylation of Cdk5, overview, cyclin E is bound to and autophosphorylated by Cdk2 leading to its degradation
Mus musculus
Purification (Commentary)
Purification (Commentary)
Organism
Cdk5 from rat brain
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
cerebral cortex
-
Rattus norvegicus
-
hippocampus
-
Rattus norvegicus
-
muscle
-
Mus musculus
-
muscle
-
Homo sapiens
-
muscle
-
Rattus norvegicus
-
neuron
-
Mus musculus
-
neuron
-
Homo sapiens
-
neuron
-
Rattus norvegicus
-
SH-SY5Y cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
ATP + tau protein
cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35
666467
Mus musculus
ADP + phosphorylated tau protein
-
-
-
?
ATP + tau protein
cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35
666467
Rattus norvegicus
ADP + phosphorylated tau protein
-
-
-
?
ATP + [tau protein]
Cdk5-p25 or Cdk5-p35, see also EC 2.7.11.26
666467
Mus musculus
ADP + O-phospho-[tau-protein]
-
-
-
?
ATP + [tau protein]
Cdk5-p25 or Cdk5-p35, see also EC 2.7.11.26, phosphorylation at Ser202 and Thr205
666467
Rattus norvegicus
ADP + O-phospho-[tau-protein]
-
-
-
?
additional information
the CDKs are involved in regulation of cell cycle and neuronal differentiation
666467
Homo sapiens
?
-
-
-
?
additional information
the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia
666467
Mus musculus
?
-
-
-
?
additional information
the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia
666467
Rattus norvegicus
?
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
Cdc2
-
Mus musculus
Cdc2
-
Homo sapiens
Cdc2
-
Rattus norvegicus
Cdk1
-
Mus musculus
Cdk1
-
Homo sapiens
Cdk1
-
Rattus norvegicus
Cdk5
-
Mus musculus
Cdk5
-
Homo sapiens
Cdk5
-
Rattus norvegicus
cyclin-dependent kinase 5
-
Mus musculus
cyclin-dependent kinase 5
-
Homo sapiens
cyclin-dependent kinase 5
-
Rattus norvegicus
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Mus musculus
ATP
-
Homo sapiens
ATP
-
Rattus norvegicus
cyclin B
interacts with and activates Cdc2/Cdk1
Mus musculus
cyclin B
interacts with and activates Cdc2/Cdk1
Homo sapiens
cyclin B
interacts with and activates Cdc2/Cdk1
Rattus norvegicus
cyclin E
interacts with and activates Cdk2
Mus musculus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
p35
activation subunit, required, interacts with and activates Cdk5, laminin induces upregulation of p35, regulation of p35 expression, overview
Mus musculus
p35
activation subunit, required, interacts with and activates Cdk5, laminin induces upregulation of p35, regulation of p35 expression, overview
Homo sapiens
p35
activation subunit, required, interacts with and activates Cdk5, laminin induces upregulation of p35, regulation of p35 expression, overview
Rattus norvegicus
p39
activation subunit, can substitute for p35, interacts with and activates Cdk5
Mus musculus
p39
activation subunit, can substitute for p35, interacts with and activates Cdk5
Homo sapiens
p39
activation subunit, can substitute for p35, interacts with and activates Cdk5
Rattus norvegicus
Cloned(Commentary) (protein specific)
Commentary
Organism
regulation of p35 expression, overview
Mus musculus
regulation of p35 expression, overview
Homo sapiens
regulation of p35 expression, overview
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Mus musculus
ATP
-
Homo sapiens
ATP
-
Rattus norvegicus
cyclin B
interacts with and activates Cdc2/Cdk1
Mus musculus
cyclin B
interacts with and activates Cdc2/Cdk1
Homo sapiens
cyclin B
interacts with and activates Cdc2/Cdk1
Rattus norvegicus
cyclin E
interacts with and activates Cdk2
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
glutamate triggers the ubiquitination and subsequent degradation of p35 in neurons after autophosphorylation of Cdk5-p35 at p35
Mus musculus
additional information
glutamate triggers the ubiquitination and subsequent degradation of p35 in neurons after autophosphorylation of Cdk5-p35 at p35
Homo sapiens
additional information
glutamate triggers the ubiquitination and subsequent degradation of p35 in neurons after autophosphorylation of Cdk5-p35 at p35
Rattus norvegicus
roscovitine
-
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoskeleton
Cdk5-p35
Mus musculus
5856
-
cytoskeleton
Cdk5-p35
Rattus norvegicus
5856
-
membrane
Cdk5-p35
Mus musculus
16020
-
membrane
Cdk5-p35
Rattus norvegicus
16020
-
additional information
Ca2+ induces cleavage of p35 to p25 by calpains, which changes the localization of Cdk5 from the particulate to the soluble fraction
Mus musculus
-
-
additional information
Ca2+ induces cleavage of p35 to p25 by calpains, which changes the localization of Cdk5 from the particulate to the soluble fraction
Rattus norvegicus
-
-
soluble
Cdk5-p25
Mus musculus
-
-
soluble
Cdk5-p25
Rattus norvegicus
-
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
induces cleavage of p35 to p25 by calpains, which changes the localization of Cdk5 from the particluate to the soluble fraction
Mus musculus
Ca2+
induces cleavage of p35 to p25 by calpains, which changes the localization of Cdk5 from the particulate to the soluble fraction
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ATP + tau protein
Mus musculus
cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35
ADP + phosphorylated tau protein
-
-
?
ATP + tau protein
Rattus norvegicus
cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35
ADP + phosphorylated tau protein
-
-
?
additional information
Homo sapiens
the CDKs are involved in regulation of cell cycle and neuronal differentiation
?
-
-
?
additional information
Mus musculus
the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia
?
-
-
?
additional information
Rattus norvegicus
the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia
?
-
-
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
additional information
p35 and cyclin B are ubiquitinated prior to degradation, proteasomal degradation of p35 is induced by phosphatase inhibitor okadaic acid, proteolytic patterns of p35 amd p39, overview
Mus musculus
additional information
p35 and cyclin B are ubiquitinated prior to degradation, proteasomal degradation of p35 is induced by phosphatase inhibitor okadaic acid, proteolytic patterns of p35 amd p39, overview
Homo sapiens
additional information
p35 and cyclin B are ubiquitinated prior to degradation, proteasomal degradation of p35 is induced by phosphatase inhibitor okadaic acid, proteolytic patterns of p35 amd p39, overview
Rattus norvegicus
phosphoprotein
in S/G2 phase of the cell cycle, Cdk1/Cdc2, upon binding of cyclin B, is phosphorylated and inactivated at T14, Y15, and T161 by protein kinases Wee1 and CAK, to activate the enzyme T14 and Y15 are dephosphorylated by phosphatase Cde25, the active enzyme is only phosphorylated at T161, release of cyclin B results in complete dephosphorylation of Cdk1/Cdc2, overview, Cdk5 binds p35 and is then activated by phosphorylation at T14, Y15, and S519, the bound p35 is also autophosphorylated by Cdk5-p35 at a single site, which induces ubiquitination and subsequent degradation of p35 in neurons, release of p35 leads to dephosphorylation of Cdk5, overview
Homo sapiens
phosphoprotein
in S/G2 phase of the cell cycle, Cdk1/Cdc2, upon binding of cyclin B, is phosphorylated and inactivated at T14, Y15, and T161 by protein kinases Wee1 and CAK, to activate the enzyme T14 and Y15 are dephosphorylated by phosphatase Cde25, the active enzyme is only phosphorylated at T161, release of cyclin B results in complete dephosphorylation of Cdk1/Cdc2, overview, Cdk5 binds p35 and is then activated by phosphorylation at T14, Y15, and S519, the bound p35 is also autophosphorylated by Cdk5-p35 at a single site, which induces ubiquitination and subsequent degradation of p35 in neurons, release of p35 leads to dephosphorylation of Cdk5, overview
Rattus norvegicus
phosphoprotein
in S/G2 phase of the cell cycle, Cdk1/Cdc2, upon binding of cyclin B, is phosphorylated and inactivated at T14, Y15, and T161 by protein kinases Wee1 and CAK, to activate the enzyme T14 and Y15 are dephosphorylated by phosphatase Cde25, the active enzyme is only phosphorylated at T161, release of cyclin B results in complete dephosphorylation of Cdk1/Cdc2, overview, Cdk5 binds p35 and is then activated by phosphorylation at T14, Y15, and S519, the bound p35 is also autophosphorylated by Cdk5-p35 at a single site, which induces ubiquitination and subsequent degradation of p35 in neurons, release of p35 leads to dephosphorylation of Cdk5, overview, cyclin E is bound to and autophosphorylated by Cdk2 leading to its degradation
Mus musculus
Purification (Commentary) (protein specific)
Commentary
Organism
Cdk5 from rat brain
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
cerebral cortex
-
Rattus norvegicus
-
hippocampus
-
Rattus norvegicus
-
muscle
-
Mus musculus
-
muscle
-
Homo sapiens
-
muscle
-
Rattus norvegicus
-
neuron
-
Mus musculus
-
neuron
-
Homo sapiens
-
neuron
-
Rattus norvegicus
-
SH-SY5Y cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
ATP + tau protein
cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35
666467
Mus musculus
ADP + phosphorylated tau protein
-
-
-
?
ATP + tau protein
cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35
666467
Rattus norvegicus
ADP + phosphorylated tau protein
-
-
-
?
ATP + [tau protein]
Cdk5-p25 or Cdk5-p35, see also EC 2.7.11.26
666467
Mus musculus
ADP + O-phospho-[tau-protein]
-
-
-
?
ATP + [tau protein]
Cdk5-p25 or Cdk5-p35, see also EC 2.7.11.26, phosphorylation at Ser202 and Thr205
666467
Rattus norvegicus
ADP + O-phospho-[tau-protein]
-
-
-
?
additional information
the CDKs are involved in regulation of cell cycle and neuronal differentiation
666467
Homo sapiens
?
-
-
-
?
additional information
the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia
666467
Mus musculus
?
-
-
-
?
additional information
the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia
666467
Rattus norvegicus
?
-
-
-
?
Other publictions for EC 2.7.11.22
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737950
Harashima
Modulation of plant growth in ...
Arabidopsis thaliana
BMC Plant Biol.
16
209
2016
-
-
-
-
-
-
1
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
23
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
23
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737994
Yan
Cdk3, a conjugation-specific c ...
Tetrahymena thermophila, Tetrahymena thermophila CU427
Cell Cycle
15
2506-2514
2016
1
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
738159
Vymetalova
5-Substituted 3-isopropyl-7-[4 ...
Homo sapiens
Eur. J. Med. Chem.
110
291-301
2016
-
-
1
-
-
-
30
-
-
-
-
1
-
1
-
-
1
-
-
4
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
44
-
-
1
-
-
-
-
44
30
-
-
-
-
-
1
-
-
-
1
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739062
Petrone
Identification of candidate cy ...
Homo sapiens
Mol. Cell. Proteomics
15
2448-2461
2016
1
-
1
-
-
-
2
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737949
Huysman
Functional characterization of ...
Phaeodactylum tricornutum
BMC Plant Biol.
15
86
2015
-
-
-
-
-
-
-
-
1
-
-
-
-
17
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
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Aggarwal
Nuclear cyclin D1/CDK4 kinase ...
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Flores
Nuclear targeting of cyclin-de ...
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-
-
-
-
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-
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-
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-
-
707843
Chen
Mechanism of action of SNS-032 ...
Homo sapiens
Blood
113
4637-4645
2009
-
-
-
-
-
-
1
-
-
-
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-
1
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2
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1
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3
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2
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2
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1
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2
-
-
1
-
-
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-
-
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-
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-
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-
707917
Leitch
Cyclin-dependent kinase inhibi ...
Homo sapiens
Br. J. Pharmacol.
158
1004-1016
2009
-
-
-
-
-
-
20
-
-
-
-
4
-
2
-
-
-
-
-
3
-
-
4
-
11
-
-
-
-
-
-
-
10
-
-
59
-
-
-
10
-
-
-
59
20
-
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-
4
-
-
-
-
-
3
-
-
4
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
707985
Ali
The development of a selective ...
Homo sapiens
Cancer Res.
69
6208-6215
2009
1
-
-
-
-
-
2
-
-
-
-
-
-
4
-
-
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-
-
1
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1
-
7
-
-
-
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-
-
5
-
-
14
1
-
-
5
-
-
-
14
2
-
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-
-
-
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-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
708029
Buck
The cyclin-dependent kinase in ...
Caenorhabditis elegans
Cell Cycle
8
2613-2620
2009
-
-
-
-
-
-
2
-
-
-
-
-
-
3
-
-
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-
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2
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
708041
Jhou
Inhibition of cyclin-dependent ...
Mus musculus
Cell Prolif.
42
141-149
2009
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
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-
1
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-
1
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2
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2
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2
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
708631
Bonvini
The effect of the cyclin-depen ...
Homo sapiens
Haematologica
94
944-955
2009
-
-
-
-
-
-
1
-
-
-
-
-
-
1
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-
-
4
-
-
1
-
3
-
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2
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-
2
-
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1
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4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
708648
Kim
Insulin-like growth factor bin ...
Homo sapiens
Horm. Metab. Res.
42
165-172
2009
-
-
-
-
-
-
1
-
-
-
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4
-
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3
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4
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2
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2
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1
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3
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
708751
Mohapatra
Apoptosis of metastatic prosta ...
Homo sapiens
Int. J. Biochem. Cell Biol.
41
595-602
2009
-
-
-
-
-
-
2
-
-
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-
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-
1
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1
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2
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2
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-
1
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-
-
-
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-
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-
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-
-
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-
-
-
-
-
-
709335
Hao
The neuroprotective effects of ...
Mus musculus
J. Huazhong Univ. Sci. Technol. Med. Sci.
29
324-329
2009
-
-
-
-
-
-
-
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1
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9
-
-
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1
-
2
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-
2
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-
2
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-
1
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
709637
Mairet-Coello
Insulin-like growth factor-1 p ...
Rattus norvegicus
J. Neurosci.
29
775-788
2009
-
-
-
-
-
-
3
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-
-
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-
3
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-
-
-
-
2
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-
1
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-
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2
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2
-
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3
-
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690991
Liu
Kinetic studies of Cdk5/p25 ki ...
Homo sapiens
Biochemistry
47
8367-8377
2008
1
1
-
-
-
-
5
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
2
-
-
1
1
1
-
2
-
-
-
1
5
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
691105
Fukasawa
P53, cyclin-dependent kinase a ...
Mus musculus
Biochim. Biophys. Acta
1786
15-23
2008
1
-
-
-
-
-
3
-
1
-
-
1
-
1
-
-
-
-
-
-
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-
1
-
1
-
-
-
-
-
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-
1
-
-
-
1
-
-
1
-
-
-
-
3
-
-
1
-
-
1
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-
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691272
Lee
Synthesis and biological evalu ...
Homo sapiens
Bioorg. Med. Chem. Lett.
18
2292-2295
2008
-
-
-
-
-
-
29
-
-
-
-
-
-
3
-
-
-
-
-
12
-
-
3
-
3
-
-
-
-
-
-
-
3
-
-
71
-
-
-
3
-
-
-
71
87
-
-
-
-
-
-
-
-
-
-
-
12
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691293
Finlay
Imidazole piperazines: SAR and ...
Homo sapiens
Bioorg. Med. Chem. Lett.
18
4442-4446
2008
-
-
-
-
-
-
13
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
12
-
-
-
1
-
-
-
12
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691302
Anderson
Imidazoles: SAR and developmen ...
Homo sapiens
Bioorg. Med. Chem. Lett.
18
5487-5492
2008
-
-
-
-
-
-
25
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
3
-
-
36
-
-
-
3
-
-
-
36
50
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691554
Chen
Involvement of calpain and p25 ...
Rattus norvegicus
Brain Res.
1200
99-106
2008
4
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
-
-
2
-
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-
4
-
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691982
Peng
The cyclin-dependent kinase Cd ...
Saccharomyces cerevisiae
Dev. Cell
15
478-485
2008
-
-
-
-
-
-
-
-
1
-
-
1
-
3
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691988
Sen
The potential role of cyclin-d ...
Mus musculus
Dev. Neurosci.
30
96-104
2008
2
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
4
-
2
-
-
-
-
-
-
-
1
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693698
Liem
Cyclin-dependent kinase 2 sign ...
Mus musculus
J. Mol. Cell. Cardiol.
45
610-616
2008
1
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693747
Paoletti
Dopaminergic and glutamatergic ...
Mus musculus, Homo sapiens
J. Neurosci.
28
10090-10101
2008
2
2
-
-
-
-
2
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
6
-
4
-
-
-
-
-
-
-
2
-
-
-
2
2
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693758
Amin
Cyclin-dependent kinase 5 phos ...
Mus musculus, Rattus norvegicus
J. Neurosci.
28
3631-3643
2008
2
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
3
-
-
4
-
4
-
-
-
-
-
-
-
2
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693762
Cheung
Cyclin-dependent kinase 5 supp ...
Mus musculus
J. Neurosci.
28
4872-4877
2008
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693779
Hsiao
N-acetylcysteine prevents beta ...
Rattus norvegicus
J. Neurosci. Res.
86
2685-2695
2008
2
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694081
Kono
G1/S cyclin-dependent kinase r ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae YOC3388
Mol. Biol. Cell
19
1763-1771
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
2
-
3
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694150
Sabo
Acetylation of conserved lysin ...
Homo sapiens
Mol. Cell. Biol.
28
2201-2212
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694187
Lewis
Phosphorylation of steroidogen ...
Homo sapiens, Mus musculus
Mol. Endocrinol.
22
91-104
2008
-
-
-
-
2
-
2
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
2
-
4
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694491
Costoya
Cyclin-dependent kinase antago ...
Homo sapiens
Oncogene
27
3789-3796
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
2
-
3
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694675
Kitsios
A cyclin-dependent protein kin ...
Arabidopsis thaliana
Plant J.
54
220-235
2008
-
-
-
-
-
-
-
-
3
-
-
-
-
8
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695013
Bartova
Functional flexibility of huma ...
Homo sapiens
Protein Sci.
17
22-33
2008
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
3
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695048
Chen
A novel binding pocket of cycl ...
Homo sapiens
Proteins
74
122-132
2008
-
-
-
-
2
-
6
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
2
-
-
-
1
-
2
-
2
8
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
695133
Hume
Phosphorylation of retinoblast ...
Human betaherpesvirus 5
Science
320
797-799
2008
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2
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1
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6
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695204
Wang
Involvement of cyclin-dependen ...
Rattus norvegicus
Toxicology
248
1-7
2008
2
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695232
Wang
Cyclin-dependent kinase 9: a k ...
Homo sapiens
Trends Pharmacol. Sci.
29
302-313
2008
1
1
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17
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1
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709510
Wang
Functions, regulation and cell ...
Arabidopsis thaliana
J. Microsc.
231
234-246
2008
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7
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710113
Ivanov
(R)-roscovitine, a cyclin-depe ...
Rattus norvegicus
Neuroscience
156
277-288
2008
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1
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5
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4
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677617
Choi
Cyclin-dependent protein kinas ...
Homo sapiens
Apoptosis
12
1229-1241
2007
2
1
1
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1
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1
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1
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4
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1
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678926
Gu
Identifying allosteric fluctua ...
Homo sapiens
BMC Bioinformatics
8
45
2007
1
1
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1
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680023
Ikui
Cyclin and cyclin-dependent ki ...
Saccharomyces cerevisiae
Genetics
175
1011-1022
2007
1
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14
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14
-
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-
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-
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680111
Baatout
Histone H1 and cdk1 kinase act ...
Mus musculus
In Vivo
21
571-582
2007
-
1
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1
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5
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2
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2
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680759
Avraham
Phosphorylation of Parkin by t ...
Homo sapiens, Rattus norvegicus
J. Biol. Chem.
282
12842-12850
2007
2
1
2
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4
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1
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5
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4
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4
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6
1
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1
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2
1
2
1
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4
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1
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4
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4
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1
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681873
Yamasaki
Sensitivity of breast cancer c ...
Homo sapiens
Mol. Cancer Ther.
6
2168-2177
2007
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1
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3
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2
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1
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20
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2
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7
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1
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1
1
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5
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1
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20
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2
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681881
Larochelle
Requirements for Cdk7 in the a ...
Homo sapiens
Mol. Cell
25
839-850
2007
1
1
1
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1
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2
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1
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4
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1
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681935
Kino
Cyclin-dependent kinase 5 diff ...
Rattus norvegicus
Mol. Endocrinol.
21
1552-1568
2007
2
1
1
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1
-
1
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2
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1
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1
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2
1
1
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1
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1
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1
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1
-
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-
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-
682130
Kanungo
Cloning and characterization o ...
Danio rerio
Neurosci. Lett.
412
233-238
2007
-
1
1
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1
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4
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6
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1
1
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6
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1
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682384
Harashima
Phosphorylation of threonine 1 ...
Nicotiana tabacum, Arabidopsis thaliana
Plant J.
52
435-448
2007
4
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1
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8
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12
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2
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2
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6
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1
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8
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2
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2
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682579
Shu
Functional characterization of ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
104
9248-9253
2007
1
1
2
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2
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4
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2
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4
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1
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3
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3
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1
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1
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1
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5
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1
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3
-
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682872
Moore
Cyclin dependent kinase 2 and ...
Homo sapiens, Rattus norvegicus
Steroids
72
202-209
2007
4
1
1
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1
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6
-
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2
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4
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8
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4
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4
1
1
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1
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6
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2
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8
-
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691256
Chen
Synthesis and activity of quin ...
Homo sapiens
Bioorg. Med. Chem. Lett.
17
2134-2138
2007
-
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35
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2
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6
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2
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1
35
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35
35
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6
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691430
Cheung
The roles of cyclin-dependent ...
Mus musculus
Biotechnol. J.
2
949-957
2007
2
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1
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1
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2
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14
-
2
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1
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2
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1
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1
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2
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14
-
-
-
-
-
-
-
-
-
-
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-
-
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691679
Meuer
Cyclin-dependent kinase 5 is a ...
Rattus norvegicus
Cell Death Differ.
14
651-661
2007
-
-
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1
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1
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1
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3
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2
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2
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1
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1
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1
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1
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3
-
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2
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-
-
-
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691801
De Vivo
Computational study of the pho ...
Homo sapiens
Chemistry
13
8437-8444
2007
-
-
-
-
-
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1
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1
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1
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1
-
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692997
North
Mitotic regulation of SIRT2 by ...
Homo sapiens
J. Biol. Chem.
282
19546-19555
2007
-
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2
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4
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1
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1
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1
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4
-
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1
-
-
-
-
-
-
-
-
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693022
Taniguchi
Phosphorylation of adult type ...
Mus musculus
J. Biol. Chem.
282
7869-7876
2007
1
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3
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1
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2
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2
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1
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1
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1
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1
-
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693721
Saito
p25/cyclin-dependent kinase 5 ...
Rattus norvegicus
J. Neurochem.
102
133-140
2007
1
1
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1
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2
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1
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1
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2
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1
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2
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1
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1
1
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1
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1
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2
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1
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2
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693746
Anne
Phosphorylation of huntingtin ...
Mus musculus, Rattus norvegicus
J. Neurosci.
27
7318-7328
2007
2
-
-
-
-
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2
-
2
-
-
-
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2
-
-
-
-
-
2
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2
-
4
-
-
-
-
-
-
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2
-
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2
-
-
2
-
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-
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2
-
-
2
-
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-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693903
Sanchez
Nuclear export of the human cy ...
Homo sapiens
J. Virol.
81
11730-11736
2007
-
-
-
-
-
-
1
-
-
-
-
-
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7
-
-
-
-
-
3
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
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-
-
1
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-
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-
-
-
-
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-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694216
Huang
Pho85, a multifunctional cycli ...
Saccharomyces cerevisiae
Mol. Microbiol.
66
303-314
2007
-
-
-
-
-
-
1
-
-
-
-
-
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6
-
-
-
-
-
-
-
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9
-
2
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-
-
-
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12
-
-
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12
-
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1
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-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694510
Marchetti
Structure-based design of 2-ar ...
Homo sapiens
Org. Biomol. Chem.
5
1577-1585
2007
-
-
-
-
-
-
29
-
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-
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1
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-
-
-
-
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1
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2
-
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-
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1
3
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24
-
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1
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24
29
3
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-
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-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694625
Cui
Roles of Arabidopsis cyclin-de ...
Arabidopsis thaliana
Plant Cell
19
1388-1402
2007
-
-
2
-
2
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
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2
-
4
-
-
-
-
-
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2
-
-
-
-
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2
2
-
2
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678181
Li
Cyclin-dependent protein kinas ...
Bos taurus, Homo sapiens, Rattus norvegicus
Biochemistry
45
3134-3145
2006
2
-
1
-
-
-
1
-
1
-
2
1
-
5
-
-
-
-
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2
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4
-
6
-
-
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-
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-
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2
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1
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1
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1
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2
1
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-
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2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679021
Yang
Phosphorylation of ezrin by cy ...
Homo sapiens
Cancer Res.
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2708-2715
2006
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1
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1
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-
679024
den Hollander
Dynein light chain 1 contribut ...
Homo sapiens
Cancer Res.
66
5941-5949
2006
1
1
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3
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1
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1
1
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3
-
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1
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-
679026
Strock
Cyclin-dependent kinase 5 acti ...
Homo sapiens
Cancer Res.
66
7509-7515
2006
1
1
1
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1
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2
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4
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1
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1
1
1
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1
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4
-
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1
-
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-
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-
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-
679092
Bayart
The Bloom syndrome helicase is ...
Homo sapiens
Cell Cycle
5
1681-1686
2006
-
-
-
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1
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1
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3
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2
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1
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1
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1
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3
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-
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-
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-
679093
Wohlbold
The cyclin-dependent kinase (C ...
Mus musculus
Cell Cycle
5
546-554
2006
1
1
1
-
-
-
1
-
-
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1
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7
-
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1
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12
-
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1
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5
-
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1
1
1
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1
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1
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1
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12
-
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1
-
-
-
-
-
-
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-
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-
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-
679842
Sengupta
Regulation of phosphorylation ...
Homo sapiens
FEBS Lett.
580
5925-5933
2006
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1
1
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-
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2
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1
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1
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1
1
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1
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-
1
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-
-
-
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-
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-
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-
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679989
Enders
Traffic safety for the cell: i ...
Saccharomyces cerevisiae, Homo sapiens
Gene
371
1-6
2006
4
1
-
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2
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5
-
-
-
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1
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2
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-
-
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3
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13
-
5
-
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4
1
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2
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5
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1
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3
-
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13
-
-
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-
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-
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-
681676
Sanchez
Cyclin-dependent kinase activi ...
Homo sapiens
J. Virol.
80
5886-5896
2006
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1
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1
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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681816
Chen
Identification of an effector ...
Plasmodium falciparum
Mol. Biochem. Parasitol.
149
48-57
2006
2
-
-
-
2
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-
-
-
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-
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4
-
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1
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3
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2
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
682537
Pareek
Cyclin-dependent kinase 5 acti ...
Mus musculus, Rattus norvegicus
Proc. Natl. Acad. Sci. USA
103
791-796
2006
4
2
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-
-
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2
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3
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-
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8
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3
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4
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4
2
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2
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8
-
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3
-
-
-
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-
662686
Darios
Neurotoxic calcium transfer fr ...
Rattus norvegicus
J. Neurosci.
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4159-4168
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1
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2
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4
-
3
1
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-
1
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1
-
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1
-
1
1
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-
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1
-
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3
1
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2
-
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-
-
2
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
662855
Lambourne
Increased tau phosphorylation ...
Homo sapiens, Mus musculus
Mol. Cell. Biol.
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278-293
2005
-
-
-
-
1
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-
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6
2
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4
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5
-
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2
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7
-
5
-
-
-
-
-
-
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2
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-
-
-
-
-
2
-
1
-
-
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-
-
6
2
-
4
-
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-
-
2
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664955
Zong
Cyclin-dependent kinase 11(p58 ...
Homo sapiens
FEBS Lett.
579
3579-3588
2005
1
-
1
-
-
-
-
-
1
-
1
1
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3
-
-
-
-
-
1
-
-
2
1
2
-
-
-
-
-
-
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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665645
Habran
Varicella-Zoster Virus IE63 Pr ...
Chlorocebus aethiops
J. Biol. Chem.
280
29135-29143
2005
-
-
-
-
-
-
2
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1
1
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1
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2
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-
-
-
-
1
-
-
3
-
5
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
1
1
-
1
-
-
-
-
-
1
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
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665977
VanderWel
Pyrido[2,3-d]pyrimidin-7-ones ...
Homo sapiens
J. Med. Chem.
48
2371-2387
2005
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-
-
-
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38
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1
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3
-
-
-
-
-
2
-
-
-
-
4
1
-
-
-
1
-
-
4
-
-
-
-
-
-
4
-
-
-
-
38
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
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-
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665980
Brana
Pyrazolo[3,4-c]pyridazines as ...
Marthasterias glacialis, Homo sapiens
J. Med. Chem.
48
6843-6854
2005
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-
1
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48
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2
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2
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-
1
-
-
1
-
-
2
-
2
2
-
-
-
2
-
-
4
-
-
-
-
-
-
4
1
-
-
-
48
-
-
-
2
-
-
-
-
-
1
-
1
-
-
2
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
665982
Lu
Crystal structure of a human c ...
Homo sapiens
J. Med. Chem.
48
737-743
2005
1
1
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1
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8
-
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1
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1
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3
-
-
-
-
-
-
-
-
2
-
4
1
-
-
-
1
-
-
3
-
-
-
1
1
-
3
1
-
-
-
8
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
666109
Van Dross
Constitutively active K-cyclin ...
Homo sapiens
J. Natl. Cancer Inst.
97
656-666
2005
-
-
-
-
-
1
-
-
2
1
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2
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4
-
1
1
-
-
3
-
-
5
-
3
1
-
-
-
1
-
-
7
-
-
-
-
-
-
7
-
-
1
-
-
-
-
2
1
-
2
-
-
1
1
-
3
-
-
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
666117
Wei
Control of cyclin-dependent ki ...
Mus musculus, Mus musculus ICR
J. Neurochem.
93
502-512
2005
3
-
-
-
1
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3
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1
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9
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2
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4
-
-
2
-
2
-
-
-
-
-
-
-
1
-
-
-
3
-
-
1
-
1
-
-
3
-
-
-
1
-
-
-
-
2
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666120
Zhu
Activation of latent cyclin-de ...
Rattus norvegicus
J. Neurochem.
94
1535-1545
2005
5
-
-
-
-
-
2
-
-
1
-
1
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3
-
1
1
-
-
2
-
-
3
-
2
1
-
-
-
1
-
-
1
-
-
-
5
-
-
1
-
-
-
-
2
-
-
-
1
-
1
-
-
1
1
-
2
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
666347
Narayanan
Cyclin-dependent kinase activi ...
Homo sapiens
Mol. Cell. Biol.
25
264-277
2005
-
-
1
-
-
-
1
-
-
-
-
2
-
1
-
-
1
-
-
1
-
-
4
-
2
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
1
-
-
-
-
-
2
-
-
-
1
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666440
Loog
Cyclin specificity in the phos ...
Saccharomyces cerevisiae
Nature
434
104-108
2005
-
-
-
-
1
-
-
4
-
1
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1
-
2
-
-
1
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-
-
-
-
5
-
1
-
-
-
3
1
-
-
4
-
-
-
-
-
-
4
-
1
-
-
-
-
4
-
1
-
1
-
-
-
1
-
-
-
-
5
-
-
-
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3
1
-
-
-
-
-
-
-
-
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666466
Hahn
Role of cyclin-dependent kinas ...
Gallus gallus
Neuroscience
134
449-465
2005
1
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1
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3
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2
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4
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3
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2
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-
-
-
-
-
1
-
-
-
1
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-
1
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-
-
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1
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3
-
-
2
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-
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-
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4
-
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3
-
-
-
-
-
-
-
-
-
-
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666588
Gutierrez
Maize cyclin D2 expression, as ...
Zea mays
Plant Cell Physiol.
46
166-173
2005
-
-
-
-
-
-
-
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1
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3
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1
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1
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5
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3
1
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1
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2
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-
-
-
-
-
2
-
-
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1
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3
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-
1
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5
-
1
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1
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666635
Corellou
Atypical regulation of a green ...
Ostreococcus tauri
Plant Physiol.
138
1627-1636
2005
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1
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1
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1
1
1
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8
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1
1
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1
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3
1
3
1
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3
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1
3
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-
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1
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1
1
1
1
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1
1
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1
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3
1
1
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-
-
-
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-
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-
-
-
-
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666728
Watanabe
Cyclin-dependent kinase (CDK) ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
102
11663-11668
2005
-
-
-
-
-
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1
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1
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2
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1
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1
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-
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3
-
1
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-
-
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2
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-
-
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-
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2
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1
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1
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2
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1
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3
-
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-
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-
-
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666744
Lim
Cyclin-dependent kinase 6 asso ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
102
5156-5161
2005
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1
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2
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1
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1
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1
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2
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-
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-
-
-
2
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-
-
-
-
1
2
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-
-
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2
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2
1
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1
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1
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1
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-
-
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-
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666862
Bartova
The mechanism of inhibition of ...
Homo sapiens
Protein Sci.
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445-451
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1
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1
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1
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2
1
2
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-
-
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2
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-
-
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2
1
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-
1
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1
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1
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-
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2
1
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662688
Shelton
Effects of cyclin-dependent ki ...
Mus musculus
J. Neurosci. Res.
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110-120
2004
4
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1
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11
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5
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5
1
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1
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1
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4
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1
1
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1
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1
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2
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11
-
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5
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1
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1
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663933
Bukczynska
The T-cell protein tyrosine ph ...
Homo sapiens
Biochem. J.
380
939-949
2004
1
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3
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1
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3
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1
1
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-
1
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2
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1
-
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2
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-
-
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3
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1
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1
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1
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3
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1
-
-
-
1
-
-
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-
664030
Li
The nuclear protein p34SEI-1 r ...
Homo sapiens
Biochemistry
43
4394-4399
2004
1
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
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2
-
2
1
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-
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1
-
-
2
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1
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2
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-
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1
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1
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-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
664179
Kesavapany
Neuronal cyclin-dependent kina ...
Danio rerio, Saccharomyces cerevisiae, Caenorhabditis elegans, Canis lupus familiaris, Drosophila melanogaster, Homo sapiens, Doryteuthis pealeii, Mus musculus, Rattus norvegicus, Sus scrofa
Biochim. Biophys. Acta
1697
143-153
2004
13
-
10
-
1
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11
-
13
1
-
46
-
10
-
1
-
-
-
25
-
-
81
-
10
-
-
-
-
-
-
-
10
-
-
-
13
-
10
10
-
1
-
-
11
-
-
13
1
-
46
-
-
1
-
-
25
-
-
81
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664332
Yang
Multisite phosphorylation and ...
eukaryota
Biophys. J.
86
3432-3443
2004
1
-
-
-
-
-
1
1
-
-
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1
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1
-
1
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-
-
-
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1
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1
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-
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2
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1
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2
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1
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1
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1
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1
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-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664536
Andres
Control of vascular cell proli ...
Homo sapiens, Mus musculus, Rattus norvegicus
Cardiovasc. Res.
63
11-21
2004
3
1
-
-
1
-
29
-
-
-
-
12
-
3
-
3
-
-
-
7
-
-
21
-
3
-
-
-
-
-
-
-
6
-
-
8
3
1
-
6
-
1
-
8
29
-
-
-
-
-
12
-
-
3
-
-
7
-
-
21
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
665497
Harwell
Activation of cyclin-dependent ...
Homo sapiens
J. Biol. Chem.
279
12695-12705
2004
1
-
1
-
1
-
-
-
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1
-
1
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1
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1
-
-
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1
-
-
2
-
2
1
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-
-
1
-
-
3
-
-
-
1
-
1
3
-
1
-
-
-
-
-
-
1
-
1
-
-
1
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
666186
Sanchez
Cyclin-dependent kinase activi ...
Homo sapiens
J. Virol.
78
11219-11232
2004
-
-
-
-
-
-
3
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-
-
-
1
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3
-
-
-
-
-
3
-
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1
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1
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-
-
-
-
-
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1
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-
-
-
-
1
-
-
-
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3
-
-
-
-
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1
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-
-
-
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3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666340
Pic-Taylor
Regulation of cell cycle-speci ...
Saccharomyces cerevisiae
Mol. Cell. Biol.
24
10036-10046
2004
3
-
-
-
-
-
-
-
1
-
-
1
-
3
-
1
-
-
-
-
-
-
2
1
2
-
1
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-
-
-
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1
-
-
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3
-
-
1
-
-
-
-
-
-
-
1
-
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1
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1
-
-
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
666401
Zhen
Regulation of cyclin-dependent ...
Rattus norvegicus
Mol. Pharmacol.
66
1500-1507
2004
3
-
-
-
-
-
2
-
-
1
-
3
-
5
-
-
-
-
-
2
1
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3
-
2
1
-
-
-
1
-
-
1
-
-
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3
-
-
1
-
-
-
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2
-
-
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1
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3
-
-
-
-
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2
1
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
666468
Gompel
Expression and activity of cyc ...
Homo sapiens
Neurosignals
13
134-143
2004
1
-
-
-
-
-
3
-
-
1
-
1
-
1
-
-
1
-
-
3
-
-
2
-
3
1
-
-
-
1
-
-
2
-
-
-
1
-
-
2
-
-
-
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3
-
-
-
1
-
1
-
-
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1
-
3
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
666574
Boudolf
The plant-specific cyclin-depe ...
Arabidopsis thaliana
Plant Cell
16
2683-2692
2004
-
-
1
-
1
-
-
-
-
-
-
1
-
4
-
-
-
-
-
1
-
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1
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1
-
-
-
-
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-
-
-
-
-
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-
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1
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1
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1
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1
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666575
Shimotohno
The plant-specific kinase CDKF ...
Arabidopsis thaliana
Plant Cell
16
2954-2966
2004
1
-
1
-
1
-
-
-
1
-
1
1
-
5
-
1
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
2
-
-
-
1
-
1
2
-
1
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-
-
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1
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1
1
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1
-
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666624
Vanstraelen
A plant-specific subclass of C ...
Arabidopsis thaliana
Plant Physiol.
135
1417-1429
2004
-
-
1
-
-
-
-
-
1
-
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1
-
3
-
-
-
-
-
-
-
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2
-
1
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-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666718
Fu
Cyclin-dependent kinase 5 phos ...
Mus musculus
Proc. Natl. Acad. Sci. USA
101
6728-6733
2004
3
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1
-
1
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1
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2
-
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1
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2
-
-
1
-
-
4
-
-
2
-
2
1
-
-
-
-
-
-
1
-
-
-
3
-
1
1
-
1
-
-
1
-
-
2
-
-
1
-
-
-
1
-
4
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
490931
Adams Joseph
Activation loop phosphorylatio ...
eukaryota
Biochemistry
42
601-607
2003
1
-
-
-
-
-
-
-
-
1
-
1
-
1
-
1
-
1
-
-
-
-
2
-
4
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660948
Bain
The specificities of protein k ...
Homo sapiens
Biochem. J.
371
199-204
2003
1
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-
-
-
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5
-
-
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-
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1
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-
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-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
662124
Takahashi
Tau phosphorylation by cyclin- ...
Mus musculus
J. Biol. Chem.
278
10506-10515
2003
2
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-
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1
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-
-
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1
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1
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2
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-
-
-
-
6
-
-
3
-
3
1
-
-
-
1
-
-
1
-
-
-
2
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
6
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
662152
Hamdane
Mitotic-like tau phosphorylati ...
Homo sapiens
J. Biol. Chem.
278
34026-34034
2003
1
-
-
-
-
-
3
-
2
1
-
2
-
1
-
-
-
-
-
2
-
-
3
-
2
1
-
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
-
-
3
-
-
2
1
-
2
-
-
-
-
-
2
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
664005
Li
An NF-kappaB-specific inhibito ...
Homo sapiens
Biochemistry
42
13476-13483
2003
-
-
1
-
3
-
4
-
-
1
-
2
-
4
-
-
1
-
-
-
-
-
2
-
2
1
-
-
-
1
-
-
2
-
-
-
-
-
1
2
-
3
-
-
4
-
-
-
1
-
2
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
664160
Sachs
Cyclin-dependent kinase 11p110 ...
Homo sapiens
Biochim. Biophys. Acta
1624
98-108
2003
-
-
1
-
1
-
-
-
-
1
1
1
-
2
-
1
1
-
-
-
-
-
3
1
3
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
1
1
1
-
-
1
1
-
-
-
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
664689
Furet
X-ray crystallographic studies ...
Homo sapiens
Curr. Med. Chem. Anticancer Agents
3
15-23
2003
-
1
-
-
-
-
28
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
28
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
665053
D'Angiolella
The spindle checkpoint require ...
Homo sapiens, Xenopus laevis
Genes Dev.
17
2520-2525
2003
-
-
-
-
-
-
4
-
-
-
-
4
-
6
-
-
-
-
-
2
-
-
6
-
6
2
-
-
-
-
-
-
6
-
-
-
-
-
-
6
-
-
-
-
4
-
-
-
-
-
4
-
-
-
-
-
2
-
-
6
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
665056
Dou
The PHOA and PHOB cyclin-depen ...
Aspergillus nidulans
Genetics
165
1105-1115
2003
-
-
1
-
2
-
-
-
-
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1
1
-
7
-
-
-
-
-
-
-
-
1
1
3
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
665488
Li
Cyclin-dependent kinase-5 is i ...
Mus musculus, Rattus norvegicus
J. Biol. Chem.
278
35702-35709
2003
2
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1
-
1
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2
-
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2
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5
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3
-
-
-
-
-
4
-
-
8
-
4
-
-
-
-
1
-
-
2
-
-
-
2
-
1
2
-
1
-
-
2
-
-
-
2
-
5
-
-
-
-
-
4
-
-
8
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
665840
Vax
Activating point mutations in ...
Homo sapiens
J. Endocrinol.
178
301-310
2003
-
-
1
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3
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1
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-
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2
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3
-
-
-
-
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4
-
-
3
-
4
-
-
-
-
-
-
-
5
-
-
-
-
-
1
5
-
3
-
-
1
-
-
-
-
-
2
-
-
-
-
-
4
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
665862
Freeman
Isolation, characterization an ...
Helianthus tuberosus
J. Exp. Bot.
54
303-308
2003
-
-
2
-
-
-
-
-
-
-
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2
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6
-
-
-
-
-
6
-
-
2
-
2
-
-
-
-
-
-
-
6
-
-
-
-
-
2
6
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
665968
Woodard
Oxindole-based compounds are s ...
Homo sapiens, Plasmodium falciparum
J. Med. Chem.
46
3877-3882
2003
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2
1
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12
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2
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5
-
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1
1
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-
-
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2
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4
2
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-
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2
-
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3
-
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11
-
2
1
3
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-
-
11
12
-
-
-
2
-
-
-
-
-
1
-
-
-
-
2
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
666124
Rideout
Cyclin-dependent kinase activi ...
Rattus norvegicus
J. Neurosci.
23
1237-1245
2003
1
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1
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3
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1
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1
-
-
-
-
-
1
-
-
2
-
3
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
1
-
-
3
-
-
1
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666184
Davido
The differential requirement f ...
Homo sapiens
J. Virol.
77
12603-12616
2003
-
-
-
-
-
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1
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-
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1
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7
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-
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1
-
-
1
-
1
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-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666185
Sanchez
Mechanisms governing maintenan ...
Homo sapiens
J. Virol.
77
13214-13224
2003
1
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2
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1
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4
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1
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1
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1
1
2
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-
-
-
-
-
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2
-
-
-
1
-
-
2
-
-
-
-
2
-
-
1
-
-
1
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666467
Hisanaga
The regulation of cyclin-depen ...
Homo sapiens, Mus musculus, Rattus norvegicus
Neurosignals
12
221-229
2003
6
-
3
-
-
-
4
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8
2
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5
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3
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6
1
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12
-
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7
-
12
-
-
-
-
-
-
-
7
-
-
-
6
-
3
7
-
-
-
-
4
-
-
8
2
-
5
-
-
6
1
-
12
-
-
7
-
-
-
-
-
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The genome sequence of Schizos ...
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Shotgun identification of prot ...
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A gene encoding a putative GTP ...
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The genome sequence of Drosoph ...
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A pcl-like cyclin activates th ...
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Machida
A 38 kb segment containing the ...
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Cloning and characterization o ...
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Salanoubat
Sequence and analysis of chrom ...
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Analysis of yeast protein kina ...
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The Caenorhabditis elegans gen ...
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Sequence and analysis of chrom ...
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Reconstitution of the transcri ...
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The PISSLRE gene: structure, e ...
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Identification and characteriz ...
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Characterization of the Prk1 p ...
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Yeast
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T-loop deletion of CDC2 from b ...
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Prevalence of p16 and CDK4 ger ...
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Gray
Exploiting chemical libraries, ...
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The molecular mechanism of mit ...
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Prediction of the coding seque ...
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Transcript mapping in a 46-kb ...
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Genomics
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The nucleotide sequence of Sac ...
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490800
Johnson
Active and inactive protein ki ...
Homo sapiens
Cell
85
149-158
1996
1
-
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-
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-
1
-
1
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1
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1
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1
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1
1
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1
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-
1
1
-
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-
-
-
-
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-
491374
Saiz
The sequence of a 20.3 kb DNA ...
Saccharomyces cerevisiae
Yeast
12
1077-1084
1996
-
-
-
-
-
-
-
-
-
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1
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491450
Sauer
Novel members of the cdc2-rela ...
Drosophila melanogaster
Mol. Biol. Cell
7
1759-1769
1996
-
-
-
-
-
-
-
-
-
-
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9
-
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2
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-
491478
Zuo
Germline mutations in the p16I ...
Homo sapiens
Nat. Genet.
12
97-99
1996
-
-
-
-
-
-
-
-
-
-
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1
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1
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-
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-
491510
Schulze-Gahmen
High-resolution crystal struct ...
Homo sapiens
J. Med. Chem.
39
4540-4546
1996
-
-
-
1
-
-
-
-
-
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3
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1
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1
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-
491511
Russo
Structural basis of cyclin-dep ...
Homo sapiens
Nat. Struct. Biol.
3
696-700
1996
-
-
-
1
-
-
-
-
-
-
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2
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1
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1
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491512
Russo
Crystal structure of the p27Ki ...
Homo sapiens
Nature
382
325-331
1996
-
-
-
1
-
-
-
-
-
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-
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3
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1
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1
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-
491513
De Azevedo
Structural basis for specifici ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
93
2735-2740
1996
-
-
-
1
-
-
1
-
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1
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1
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1
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1
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491514
Bourne
Crystal structure and mutation ...
Homo sapiens
Cell
84
863-874
1996
-
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-
1
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-
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5
-
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1
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1
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-
491536
Damagnez
Candida albicans CDK1 and CYB1 ...
Candida albicans
Gene
172
137-141
1996
-
-
1
-
-
-
-
-
-
-
-
-
-
8
-
-
-
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1
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1
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-
-
-
-
-
-
-
-
491586
Fobert
Distinct classes of cdc2-relat ...
Antirrhinum majus
Plant Cell
8
1465-1476
1996
-
-
-
-
-
-
-
-
-
-
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8
-
-
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3
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-
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-
-
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-
532803
Kaldis
The Cdk-activating kinase (CAK ...
Saccharomyces cerevisiae
Cell
86
553-564
1996
-
-
1
-
-
-
-
-
-
-
-
1
-
4
-
-
1
-
-
-
-
-
1
1
1
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-
-
-
-
-
-
-
-
-
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-
1
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-
-
-
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-
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-
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1
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1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
490796
Hunter
Protein kinases and phosphatas ...
eukaryota
Cell
80
225-236
1995
2
-
-
-
-
-
1
-
1
1
-
2
-
1
-
1
-
-
-
-
-
-
4
2
4
-
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
1
-
-
1
1
-
2
-
-
1
-
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491458
Baur
Sequence analysis of a 5.6 kb ...
Saccharomyces cerevisiae
Yeast
11
455-458
1995
-
-
-
-
-
-
-
-
2
-
-
-
-
5
-
-
-
-
-
1
-
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-
-
1
-
-
-
-
-
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2
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1
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491479
Wolfel
A p16INK4a-insensitive CDK4 mu ...
Homo sapiens
Science
269
1281-1284
1995
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
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-
-
-
-
-
1
-
1
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-
1
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-
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1
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491515
Jeffrey
Mechanism of CDK activation re ...
Homo sapiens
Nature
376
313-320
1995
-
-
-
1
-
-
-
-
-
-
-
-
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3
-
-
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-
-
-
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1
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-
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1
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491525
Rasmussen
A 37.5 kb region of yeast chro ...
Saccharomyces cerevisiae
Yeast
11
873-883
1995
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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-
1
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-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491534
Mottram
A family of trypanosome cdc2-r ...
Trypanosoma brucei brucei
Gene
162
147-152
1995
-
-
3
-
-
-
-
-
-
-
-
3
-
7
-
2
-
-
-
-
-
-
3
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
3
-
-
2
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491538
Navarro-Garcia
Functional characterization of ...
Candida albicans
Mol. Cell. Biol.
15
2197-2206
1995
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
1
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-
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491547
Tassan
Identification of human cyclin ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
92
8871-8875
1995
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491548
Ohshima
Molecular cloning and chromoso ...
Mus musculus
Genomics
28
585-588
1995
-
-
1
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
1
-
-
2
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491559
Best
Cloning of a full-length cDNA ...
Homo sapiens
Biochem. Biophys. Res. Commun.
208
562-568
1995
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491561
Gervasi
The Xenopus laevis homologue t ...
Xenopus laevis
Brain Res. Mol. Brain Res.
33
192-200
1995
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
3
-
-
3
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491564
Michaelis
A Dictyostelium discoideum gen ...
Dictyostelium discoideum
Biochem. Cell Biol.
73
51-58
1995
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491588
Kotani
A variant form of cyclin-depen ...
Rattus norvegicus
Oncogene
10
663-669
1995
-
-
-
-
-
-
-
-
-
-
-
1
-
5
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491589
Hosokawa
Synergistic gene expressions o ...
Rattus norvegicus
Biochem. Mol. Biol. Int.
37
393-399
1995
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
532685
Murakami
Analysis of the nucleotide seq ...
Saccharomyces cerevisiae
Nat. Genet.
10
261-268
1995
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
532808
Pu
Mitotic destruction of the cel ...
Aspergillus nidulans
EMBO J.
14
995-1003
1995
-
-
-
-
1
1
-
-
-
-
-
1
-
3
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
532809
Pu
Isolation of a functional homo ...
Aspergillus nidulans, Neurospora crassa
J. Biol. Chem.
270
18110-18116
1995
-
-
1
-
1
-
-
-
-
-
-
-
-
7
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
489976
MacKintosh
Inhibitors of protein kinases ...
eukaryota
Trends Biochem. Sci.
19
444-448
1994
1
-
-
-
-
-
3
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
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1
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1
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490797
Kemp
Substrate and pseudosubstrate ...
Mammalia
Trends Biochem. Sci.
19
440-444
1994
2
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2
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491369
Wilson
2.2 Mb of contiguous nucleotid ...
Caenorhabditis elegans
Nature
368
32-38
1994
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491449
Roemer
DNA sequence analysis of a 10. ...
Saccharomyces cerevisiae
Yeast
10
1527-1530
1994
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1
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491485
Kaffman
Phosphorylation of the transcr ...
Saccharomyces cerevisiae
Science
263
1153-1156
1994
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491489
Labbe
p40MO15 associates with a p36 ...
Xenopus laevis
EMBO J.
13
5155-5164
1994
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1
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1
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491522
Kato
Regulation of cyclin D-depende ...
Mus musculus
Mol. Cell. Biol.
14
2713-2721
1994
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1
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2
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491531
Mori
The identification of a Caenor ...
Caenorhabditis elegans
Mol. Gen. Genet.
245
781-786
1994
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1
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8
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1
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1
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1
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1
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491537
Sherlock
Molecular cloning and analysis ...
Candida albicans
Mol. Gen. Genet.
245
716-723
1994
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1
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9
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1
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491542
Kerr
Characterization of the synthe ...
Rattus norvegicus
Biochim. Biophys. Acta
1218
375-387
1994
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1
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1
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1
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1
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1
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491544
Hellmich
Cloning and characterization o ...
Drosophila melanogaster
FEBS Lett.
356
317-321
1994
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1
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2
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1
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1
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491545
Yang
Identification of cDNAs encodi ...
Bos taurus
Gene
141
283-286
1994
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1
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1
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1
1
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1
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1
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1
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491549
Ino
Expression of CDK5 (PSSALRE ki ...
Mus musculus
Brain Res.
661
196-206
1994
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1
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13
-
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1
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13
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491552
Wu
Molecular cloning of the human ...
Homo sapiens
Oncogene
9
2089-2096
1994
-
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1
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1
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1
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1
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1
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-
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1
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491553
Tassan
Cell cycle analysis of the act ...
Homo sapiens
J. Cell. Biol.
127
467-478
1994
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1
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8
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2
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1
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-
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491554
Levedakou
Two novel human serine/threoni ...
Homo sapiens
Oncogene
9
1977-1988
1994
-
-
1
-
-
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-
-
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5
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3
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1
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1
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3
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-
-
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491555
Fisher
A novel cyclin associates with ...
Homo sapiens
Cell
78
713-724
1994
-
-
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2
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3
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2
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2
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491556
Darbon
Cloning, expression and subcel ...
Homo sapiens
Oncogene
9
3127-3138
1994
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1
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9
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1
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1
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491560
Grana
PITALRE, a nuclear CDC2-relate ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
91
3834-3838
1994
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1
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4
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1
1
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1
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1
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1
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1
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-
-
-
-
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491562
Di Lallo
The Histoplasma capsulatum cdc ...
Histoplasma capsulatum
Gene
140
51-57
1994
-
-
-
-
-
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-
-
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6
-
-
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1
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1
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1
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-
-
-
-
-
-
-
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491567
Osmani
-
A single p34cdc2 protein kinas ...
Aspergillus nidulans
J. Cell Sci.
107
1519-1528
1994
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1
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2
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1
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-
-
-
-
-
-
-
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-
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491572
Stepanova
Sequence of the cDNA encoding ...
Mus musculus
Gene
149
321-324
1994
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1
-
-
-
-
-
-
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5
-
-
-
-
-
-
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2
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
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491573
Matsuoka
Activation of cyclin-dependent ...
Mus musculus
Mol. Cell. Biol.
14
7265-7275
1994
1
-
-
-
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-
-
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3
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
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-
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491582
Ross-Macdonald
Isolation and expression of a ...
Plasmodium falciparum
Eur. J. Biochem.
220
693-701
1994
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1
-
-
-
-
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3
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7
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-
-
-
-
-
-
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2
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1
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-
-
-
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-
-
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1
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-
-
-
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3
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-
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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491584
Grana
PISSLRE, a human novel CDC2-re ...
Homo sapiens
Oncogene
9
2097-2103
1994
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
2
-
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-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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491585
Brambilla
Molecular cloning of PISSLRE, ...
Homo sapiens
Oncogene
9
3037-3041
1994
-
-
1
-
-
-
-
-
-
-
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1
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3
-
-
-
-
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4
-
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2
-
1
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-
-
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-
1
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1
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4
-
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2
-
-
-
-
-
-
-
-
-
-
-
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-
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491462
MacNeill
Mutational analysis of the fis ...
Schizosaccharomyces pombe
Mol. Gen. Genet.
236
415-426
1993
-
-
-
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1
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-
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1
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7
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-
-
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2
-
2
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1
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1
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2
-
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-
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-
-
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491468
Valay
The kin28 protein kinase is as ...
Saccharomyces cerevisiae
J. Mol. Biol.
234
307-310
1993
-
-
-
-
-
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1
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1
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1
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
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491480
Khatib
Coamplification of the CDK4 ge ...
Homo sapiens
Cancer Res.
53
5535-5541
1993
-
-
-
-
-
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1
1
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3
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1
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1
1
1
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-
-
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1
1
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1
-
-
1
1
-
-
-
-
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-
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491494
Poon
The cdc2-related protein p40MO ...
Xenopus laevis
EMBO J.
12
3123-3132
1993
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4
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1
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-
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-
-
-
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-
-
-
-
-
-
-
-
-
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491496
Stern
Genetic analysis of the Drosop ...
Xenopus laevis
Development
117
219-232
1993
-
-
-
-
-
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1
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1
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491497
Clegg
A developmental and molecular ...
Xenopus laevis
Genome
36
676-685
1993
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1
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1
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1
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491501
Fesquet
The MO15 gene encodes the cata ...
Xenopus laevis
EMBO J.
12
3111-3121
1993
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-
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2
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1
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1
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4
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2
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1
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1
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4
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491516
De Bondt
Crystal structure of cyclin-de ...
Homo sapiens
Nature
363
595-602
1993
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1
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2
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491521
Ershler
Novel CDC2-related protein kin ...
Mus musculus
Gene
124
305-306
1993
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3
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3
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3
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3
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491528
Michaelis
The isolation from a unicellul ...
Dictyostelium discoideum
Biochim. Biophys. Acta
1179
117-124
1993
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-
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1
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6
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1
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1
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1
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491532
Cho
Cloning of the rat cyclin-depe ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
191
860-865
1993
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-
1
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4
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2
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491533
Molz
Characterization of the fissio ...
Schizosaccharomyces pombe
EMBO J.
12
1723-1732
1993
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-
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1
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1
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1
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491540
Moran
Molecular cloning of two novel ...
Arabidopsis thaliana
Biochim. Biophys. Acta
1216
9-14
1993
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-
1
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1
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1
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1
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1
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1
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1
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1
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491546
Noguchi
Molecular cloning and identifi ...
Mesocricetus auratus
Biochem. Biophys. Res. Commun.
197
1524-1529
1993
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-
1
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6
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1
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1
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491578
Lohia
Cloning of the Eh cdc2 gene fr ...
Entamoeba histolytica
Gene
127
203-207
1993
-
-
1
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11
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2
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491579
Bladt
Characterization and expressio ...
Mus musculus
Differentiation
53
115-122
1993
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1
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1
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1
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1
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1
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1
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491580
Hirt
cdc2MsB, a cognate cdc2 gene f ...
Medicago sativa
Plant J.
4
61-69
1993
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1
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12
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1
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1
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491581
Mottram
A novel CDC2-related protein k ...
Leishmania mexicana
J. Biol. Chem.
268
21044-21052
1993
-
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10
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1
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491587
Hong
p34cdc2 protein kinase homolog ...
Vigna aconitifolia
Plant Physiol.
101
1399-1400
1993
-
-
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1
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-
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-
490424
Gilardi-Hebenstreit
An Eph-related receptor protei ...
Mus musculus
Oncogene
7
2499-2506
1992
-
-
-
-
-
-
-
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1
-
4
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2
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2
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2
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1
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2
-
-
2
-
-
-
-
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-
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-
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491445
Biggs
Primary structure, expression, ...
Drosophila melanogaster
Proc. Natl. Acad. Sci. USA
89
6295-6299
1992
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-
-
-
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2
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1
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-
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-
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-
-
-
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-
491491
Eipers
Structure and expression of th ...
Homo sapiens
Genomics
13
613-621
1992
-
-
-
-
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1
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4
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2
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1
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-
-
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-
-
-
-
-
-
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-
491502
Pickham
Requirement of mosXe protein k ...
Xenopus laevis
Mol. Cell. Biol.
12
3192-3203
1992
-
-
-
-
14
-
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-
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6
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2
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14
-
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-
-
-
-
-
-
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-
-
-
-
-
-
-
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-
491503
Inze
Control of cell division in pl ...
Arabidopsis thaliana
Biochem. Soc. Trans.
20
80-84
1992
-
-
-
-
-
-
-
-
-
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1
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1
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-
-
-
-
-
-
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-
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-
491504
Imajuku
Exon-intron organization of th ...
Arabidopsis thaliana
FEBS Lett.
304
73-77
1992
-
-
-
-
-
-
-
-
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7
-
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-
-
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3
-
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-
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-
-
-
-
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491517
Gu
Cell cycle regulation of CDK2 ...
Homo sapiens
EMBO J.
11
3995-4005
1992
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1
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3
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1
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1
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-
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-
1
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1
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-
-
-
-
-
-
-
-
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-
-
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-
-
-
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-
491523
Matsushime
Identification and properties ...
Mus musculus
Cell
71
323-334
1992
-
-
-
-
-
-
-
-
-
-
-
-
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3
-
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1
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-
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-
-
-
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-
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491527
Michaelis
Isolation and characterization ...
Dictyostelium discoideum
Biochim. Biophys. Acta
1132
35-42
1992
-
-
-
-
-
-
-
-
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5
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1
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
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491541
Hirai
Isolation and characterization ...
Carassius auratus
Dev. Biol.
152
113-120
1992
-
-
-
-
-
-
-
-
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1
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1
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2
-
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-
1
1
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-
-
-
-
-
-
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1
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2
-
-
-
1
-
-
-
-
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-
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491565
Meyerson
A family of human cdc2-related ...
Homo sapiens
EMBO J.
11
2909-2917
1992
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-
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11
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7
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-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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491568
Brown
The Crithidia fasciculata CRK ...
Crithidia fasciculata
Nucleic Acids Res.
20
5451-5456
1992
-
-
-
-
-
-
-
-
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1
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5
-
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-
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1
-
1
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-
-
-
-
-
-
-
-
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1
-
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-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491569
Lew
Brain proline-directed protein ...
Bos taurus
J. Biol. Chem.
267
25922-25926
1992
-
-
1
-
-
-
-
-
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2
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5
-
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-
-
-
-
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1
1
1
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-
-
-
-
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-
-
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1
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-
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2
-
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-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491570
Xiong
D Type cyclins associate with ...
Rattus norvegicus
Cell
71
505-514
1992
-
-
-
-
-
-
-
-
-
-
-
-
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2
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491571
Hellmich
Neuronal cdc2-like kinase: a c ...
Rattus norvegicus
Proc. Natl. Acad. Sci. USA
89
10867-10871
1992
-
-
-
-
-
-
-
-
-
-
-
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6
-
-
-
-
-
-
-
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-
-
1
-
-
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-
-
-
-
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491575
Ershler
Identification of new protein ...
Mus musculus
Dokl. Akad. Nauk
324
893-897
1992
-
-
-
-
-
-
-
-
-
-
-
-
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1
-
-
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-
-
1
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1
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-
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1
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-
-
491577
Okuda
PCTAIRE-1 and PCTAIRE-3, two m ...
Mus musculus
Oncogene
7
2249-2258
1992
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7
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3
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1
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491447
Irie
SGV1 encodes a CDC28/cdc2-rela ...
Saccharomyces cerevisiae
Cell
65
785-795
1991
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491482
Krek
Differential phosphorylation o ...
Gallus gallus
EMBO J.
10
305-316
1991
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491493
Colasanti
Isolation and characterization ...
Zea mays
Proc. Natl. Acad. Sci. USA
88
3377-3381
1991
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491495
Paris
Cloning by differential screen ...
Xenopus laevis
Proc. Natl. Acad. Sci. USA
88
1039-1043
1991
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1
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491505
Hirayama
Identification of two cell-cyc ...
Arabidopsis thaliana
Gene
105
159-165
1991
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2
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8
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2
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491506
Ferreira
The Arabidopsis functional hom ...
Arabidopsis thaliana
Plant Cell
3
531-540
1991
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8
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1
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491507
Kidd
Regulated expression of a cell ...
Mus musculus
Cell Growth Differ.
2
85-93
1991
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1
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2
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2
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1
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1
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2
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1
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491518
Tsai
Isolation of the human cdk2 ge ...
Homo sapiens
Nature
353
174-177
1991
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4
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491519
Ninomiya-Tsuji
Cloning of a human cDNA encodi ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
88
9006-9010
1991
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1
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491520
Elledge
A new human p34 protein kinase ...
Homo sapiens
EMBO J.
10
2653-2659
1991
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491576
Lee
CTD kinase large subunit is en ...
Saccharomyces cerevisiae
Gene Expr.
1
149-167
1991
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1
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3
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1
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1
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1
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491473
Th'ng
The FT210 cell line is a mouse ...
Mus musculus
Cell
63
313-324
1990
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1
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491474
Spurr
Cloning of the mouse homologue ...
Mus musculus
DNA Seq.
1
49-54
1990
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1
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1
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1
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1
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491488
Matsushime
A novel mammalian protein kina ...
Rattus norvegicus, Homo sapiens
Mol. Cell. Biol.
10
2261-2268
1990
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2
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2
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491490
Shuttleworth
p40MO15, a cdc2-related protei ...
Xenopus laevis
EMBO J.
9
3233-3240
1990
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1
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491492
Bunnell
Increased expression of a 58-k ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
87
7467-7471
1990
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1
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491498
Jimenez
Complementation of fission yea ...
Xenopus laevis
EMBO J.
9
3565-3571
1990
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491499
Lehner
Drosophila cdc2 homologul: a f ...
Xenopus laevis, Drosophila melanogaster
EMBO J.
9
3573-3581
1990
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2
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491526
Yoshida
Initiation of meiosis and spor ...
Saccharomyces cerevisiae
Mol. Gen. Genet.
221
176-186
1990
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1
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491463
Gould
Tyrosine phosphorylation of th ...
Schizosaccharomyces pombe
Nature
342
39-45
1989
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1
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1
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491475
Cisek
Phosphorylation of RNA polymer ...
Mus musculus
Nature
339
679-684
1989
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1
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2
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1
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1
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2
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491483
Krek
Structure and developmental ex ...
Gallus gallus
EMBO J.
8
3071-3078
1989
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491535
Riabowol
The cdc2 kinase is a nuclear p ...
Rattus norvegicus
Cell
57
393-401
1989
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-
-
-
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2
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1
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5
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1
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1
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2
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1
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1
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491471
Draetta
Activation of cdc2 protein kin ...
Homo sapiens
Cell
54
17-26
1988
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-
-
-
-
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-
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1
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1
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491486
Toh-e
PHO85, a negative regulator of ...
Saccharomyces cerevisiae
Mol. Gen. Genet.
214
162-164
1988
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-
-
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1
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4
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1
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1
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1
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532807
Osmani
Mitotic induction and maintena ...
Aspergillus nidulans
Cell
53
237-244
1988
-
-
-
-
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1
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1
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491246
Hanks
Homology probing: identificati ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
84
388-392
1987
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491464
Brizuela
p13suc1 acts in the fission ye ...
Schizosaccharomyces pombe
EMBO J.
6
3507-3514
1987
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1
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1
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491472
Lee
Complementation used to clone ...
Homo sapiens
Nature
327
31-35
1987
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1
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1
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491487
Uesono
Negative regulators of the PHO ...
Saccharomyces cerevisiae
Nucleic Acids Res.
15
10299-10309
1987
-
-
-
-
-
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4
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2
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491469
Simon
KIN28, a yeast split gene codi ...
Saccharomyces cerevisiae
EMBO J.
5
2697-2701
1986
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4
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1
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491459
Lorincz
Primary structure homology bet ...
Saccharomyces cerevisiae
Nature
307
183-185
1984
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5
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1
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491465
Hindley
Sequence of the cell division ...
Schizosaccharomyces pombe
Gene
31
129-134
1984
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9
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1
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