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Literature summary for 2.7.11.22 extracted from
- Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator (2005), Mol. Cell. Biol., 25, 264-277.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of GST-tagged Cdk2 and GST-tagged cyclin A in Spodoptera frugiperda Sf9 cells using the baculovirus infection system | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| roscovitine | inhibits Cdk2 activity which inhibits also the progesterone receptor activity in vivo | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + progesterone receptor | Homo sapiens | cyclin-dependent kinase activity is required for progesterone receptor PR function, the phosphorylation of the receptor protein has little effect, but cyclin A/Cdk2 acts as a progesterone receptor coactivator via stimulation of PR transcription, Cdk2-cyclin A is PR-dependently recruited to the PR promoter binding to cyclin A, mechanism involving SCR-1 and regulation, overview | ADP + phosphorylated progesterone receptor | - |
? | |
| ATP + SCR-1 | Homo sapiens | Cdk2-cyclin A, phosphorylation at Lys5 regulates SCR-1 interaction with the progesterone receptor | ADP + phosphorylated SCR-1 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant GST-tagged Cdk2 and GST-tagged cyclin A from Sf9 insect cellsby glutathione affinity chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + progesterone receptor | cyclin-dependent kinase activity is required for progesterone receptor PR function, the phosphorylation of the receptor protein has little effect, but cyclin A/Cdk2 acts as a progesterone receptor coactivator via stimulation of PR transcription, Cdk2-cyclin A is PR-dependently recruited to the PR promoter binding to cyclin A, mechanism involving SCR-1 and regulation, overview | Homo sapiens | ADP + phosphorylated progesterone receptor | - |
? | |
| ATP + progesterone receptor | Cdk2-cyclin A | Homo sapiens | ADP + phosphorylated progesterone receptor | - |
? | |
| ATP + SCR-1 | Cdk2-cyclin A, phosphorylation at Lys5 regulates SCR-1 interaction with the progesterone receptor | Homo sapiens | ADP + phosphorylated SCR-1 | - |
? | |
| ATP + SCR-1 | Cdk2-cyclin A, phosphorylation at Lys5 | Homo sapiens | ADP + phosphorylated SCR-1 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CDK2 | - |
Homo sapiens |
| cyclin A/Cdk2 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| cyclin A | regulatory subunit of Cdk2 | Homo sapiens |
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Release 2023.1 (January 2023)
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