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Literature summary for 2.7.11.22 extracted from

  • Wei, F.Y.; Tomizawa, K.; Ohshima, T.; Asada, A.; Saito, T.; Nguyen, C.; Bibb, J.A.; Ishiguro, K.; Kulkarni, A.B.; Pant, H.C.; Mikoshiba, K.; Matsui, H.; Hisanaga, S.
    Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability (2005), J. Neurochem., 93, 502-512.
    View publication on PubMed
Search for more literature for 2.7.11.22

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin Ca2+/calmodulin induce the phosphorylation of p35 by Cdk5 after stimulation of the Ca2+-permeable cation channels NMDA receptor and kainate receptor, leading to cleavage of p35 to p25 Mus musculus
p25 soluble cofactor of Cdk5, cleavage of p35 to p25 Mus musculus
p35 membrane-bound cofactor of Cdk5, levels in primary embryonal cortical neurons are reduced by glutamate-induced stimulation of NMDA or kainate receptors through NMDA or kainate, cleavage of p35 to p25, reduced p35 leads to inhibition of Cdk5 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information p35 null mutant mice have a longer threshold for long term potentiation, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme cofactor p35 levels in primary embryonal cortical neurons are reduced by glutamate-induced stimulation of NMDA or kainate receptors through NMDA or kainate, p35 is reduced via proteasomal degradation, reduced p35 leads to inhibition of Cdk5, no inhibition by casein kinase inhibitor CKI-7 Mus musculus
NMDA inactivates Cdk5 by modulation of Ser67 on the protein phosphatase inhibitor-I, overview Mus musculus
roscovitine inhibits Cdk5 activity, including the p35 phosphorylation activity Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ stimulates Cdk5, Ca2+/calmodulin induce the phosphorylation of p35 by Cdk5 after stimulation of the Ca2+-permeable cation channels NMDA receptor and kainate receptor, leading to cleavage of p35 to p25 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 ICR mice
-
Mus musculus ICR
-
 ICR mice
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein p35 is degraded by the proteasome after stimulation of NMDA or kainate receptors and subsequent Ca2+/calmodulin-dependent phosphorylation of p35 by Cdk5, reduced p35 leads to inhibition of Cdk5 Mus musculus
proteolytic modification p35 is degraded by the proteasome after stimulation of NMDA or kainate receptors and subsequent Ca2+/calmodulin-dependent phosphorylation of p35 by Cdk5, p35 is cleaved to p25, reduced p35 leads to inhibition of Cdk5, overview Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
embryo
-
 Mus musculus
-
hippocampus
-
 Mus musculus
-
neuron from embryonic brain cortices Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H1
-
 Mus musculus ADP + phosphorylated histone H1
-
 ?
ATP + histone H1
-
 Mus musculus ICR ADP + phosphorylated histone H1
-
 ?

Synonyms

Synonyms Comment Organism
Cdk5
-
 Mus musculus
cyclin-dependent kinase 5
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus