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Literature summary for 2.7.11.22 extracted from

  • Furet, P.
    X-ray crystallographic studies of CDK2, a basis for cyclin-dependent kinase inhibitor design in anti-cancer drug research (2003), Curr. Med. Chem. Anticancer Agents, 3, 15-23.
    View publication on PubMed

Application

Application Comment Organism
drug development CDK2 is a target for development of small molecule inhibitors binding to the ATP binding pocket, determinations of binding structures and design of an inhibitor scaffold, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-[[(2,2-dioxido-1,3-dihydro-2-benzothien-5-yl)amino]methylene]-5-(1,3-oxazol-5-yl)-1,3-dihydro-2H-indol-2-one
-
Homo sapiens
3-[[4-([[amino(imino)methyl]amino]sulfonyl)anilino]methylene]-2-oxo-2,3-dihydro-1H-indole
-
Homo sapiens
4-(1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-N-(2-hydroxy-ethyl)-benzenesulfonamide
-
Homo sapiens
4-[2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]benzenesulfonamide
-
Homo sapiens
4-[[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino]-N-(1,3-thiazol-2-yl)benzenesulfonamide
-
Homo sapiens
4-[[(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino]-N-(2-pyridinyl)benzenesulfonamide
-
Homo sapiens
6,7-dimethoxy-N-(3hydroxyphenyl)quinazolin-4-amine
-
Homo sapiens
8-ethyl-2-[4-(4-methylpiperazin-1-yl)phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one
-
Homo sapiens
flavopiridol
-
Homo sapiens
H717
-
Homo sapiens
hymenialdisine
-
Homo sapiens
indirubin-3'-monoxime
-
Homo sapiens
indirubin-5-sulfonic acid
-
Homo sapiens
isopentenyladenine
-
Homo sapiens
additional information analysis of interactions between small molecule inhibitors with the ATP binding pocket of CDK2, determinations of binding structures and design of an inhibitor scaffold, overview Homo sapiens
N-(6-amino-pyrimidin-4-yl)-sulfanilic acid amide
-
Homo sapiens
N-methyl-4-[[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino]benzenesulfonamide
-
Homo sapiens
N-methyl-[4-[2-(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)hydrazino]phenyl]methanesulfonamide
-
Homo sapiens
N-[(9bR)-5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-alpha]isoindol-9-yl]-N'-pyridin-2-yl urea
-
Homo sapiens
N-[(9bR)-5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-alpha]isoindol-9-yl]-N'-{5-[(2S)-pyrrolidin-2-yl]-1H-pyrazol-3-yl urea
-
Homo sapiens
NU2058
-
Homo sapiens
NU6027
-
Homo sapiens
OL567
-
Homo sapiens
Olomoucine
-
Homo sapiens
PKF049-365
-
Homo sapiens
purvalanol
-
Homo sapiens
roscovitine
-
Homo sapiens
staurosporine
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
CDK2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP ATP binding pocket structure, the pocket is a cleft located at the interface between two domains, involvd residues, overview Homo sapiens