Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | CDKs are activated by phosphorylation | Mus musculus | |
additional information | CDKs are activated by phosphorylation | Homo sapiens | |
additional information | CDKs are activated by phosphorylation | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | the CDK-cyclins are targets for pharmacological and gene therapy strategies for the treatment of cardiovascular disease | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of CDK-null mutant mice | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CDK inhibitory proteins | members of the family of CDK inhibitory proteins, e.g. INK4 proteins, overview, CKIs may play a role as regulators in neointimal hyperplasia | Homo sapiens | |
CDK inhibitory proteins | members of the family of CDK inhibitory proteins, e.g. INK4 proteins, overview, CKIs may play a role as regulators in neointimal hyperplasia | Mus musculus | |
CDK inhibitory proteins | members of the family of CDK inhibitory proteins, e.g. INK4 proteins, overview, CKIs may play a role as regulators in neointimal hyperplasia | Rattus norvegicus | |
CVT-313 | inhibitor used in treatment of neointimal hyperplasia, IC50 for CDK1 is 0.004 mM, for CDK2 0.0005 mM, and for CDK4 0.215 mM | Rattus norvegicus | |
flavopiridol | inhibitor used in treatment of neointimal hyperplasia, IC50 for CDK1 is 0.0005 mM, for CDK2 0.0001 mM, for CDK4 0.000065 mM, for CDK6 0.00006 mM, and for CDK7 0.00011-0.0003 mM | Rattus norvegicus | |
INK4 proteins | inhibit CDK4 | Homo sapiens | |
INK4 proteins | inhibit CDK4 | Mus musculus | |
INK4 proteins | inhibit CDK4 | Rattus norvegicus | |
additional information | physiological effects of CDK inhibition, overview, CDKs are deactivated by dephosphorylation, protein p27Kip1 mediates CDK2 inhibition | Homo sapiens | |
additional information | physiological effects of CDK inhibition, overview, CDKs are deactivated by dephosphorylation, protein p27Kip1 mediates CDK2 inhibition | Mus musculus | |
additional information | physiological effects of CDK inhibition, overview, CDKs are deactivated by dephosphorylation, protein p27Kip1 mediates CDK2 inhibition | Rattus norvegicus | |
p15Ink4b | INK4 protein | Homo sapiens | |
p15Ink4b | INK4 protein | Mus musculus | |
p15Ink4b | INK4 protein | Rattus norvegicus | |
p16Ink4a | INK4 protein | Homo sapiens | |
p16Ink4a | INK4 protein | Mus musculus | |
p16Ink4a | INK4 protein | Rattus norvegicus | |
p18Ink4c | INK4 protein | Homo sapiens | |
p18Ink4c | INK4 protein | Mus musculus | |
p18Ink4c | INK4 protein | Rattus norvegicus | |
p19Ink4d | INK4 protein | Homo sapiens | |
p19Ink4d | INK4 protein | Mus musculus | |
p19Ink4d | INK4 protein | Rattus norvegicus | |
simvastatin | inhibition of CDK2 | Homo sapiens | |
simvastatin | inhibition of CDK2 | Mus musculus | |
simvastatin | inhibition of CDK2 | Rattus norvegicus | |
tranilast | inhibition of CDK2 and CDK4 | Homo sapiens | |
tranilast | inhibition of CDK2 and CDK4 | Mus musculus | |
tranilast | inhibition of CDK2 and CDK4 | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pocket protein p107 | Mus musculus | hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | ADP + phosphorylated pocket protein 107 | - |
? | |
ATP + pocket protein p107 | Homo sapiens | hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | ADP + phosphorylated pocket protein 107 | - |
? | |
ATP + pocket protein p107 | Rattus norvegicus | hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | ADP + phosphorylated pocket protein 107 | - |
? | |
ATP + pocket protein p130 | Mus musculus | hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | ADP + phosphorylated pocket protein 130 | - |
? | |
ATP + pocket protein p130 | Homo sapiens | hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | ADP + phosphorylated pocket protein 130 | - |
? | |
ATP + pocket protein p130 | Rattus norvegicus | hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | ADP + phosphorylated pocket protein 130 | - |
? | |
ATP + retinoblastoma protein | Mus musculus | i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | ADP + phosphorylated retinoblastoma protein | - |
? | |
ATP + retinoblastoma protein | Homo sapiens | i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | ADP + phosphorylated retinoblastoma protein | - |
? | |
ATP + retinoblastoma protein | Rattus norvegicus | i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | ADP + phosphorylated retinoblastoma protein | - |
? | |
additional information | Mus musculus | CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview | ? | - |
? | |
additional information | Homo sapiens | CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview | ? | - |
? | |
additional information | Rattus norvegicus | CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | CDK is regulated by de-/phosphorylation | Mus musculus |
phosphoprotein | CDK is regulated by de-/phosphorylation | Homo sapiens |
phosphoprotein | CDK is regulated by de-/phosphorylation | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
keratinocyte | - |
Mus musculus | - |
keratinocyte | - |
Homo sapiens | - |
keratinocyte | - |
Rattus norvegicus | - |
additional information | different CDK-cyclins are orderly activated at specific phases of the cell cycle | Homo sapiens | - |
vascular cell | - |
Mus musculus | - |
vascular cell | - |
Homo sapiens | - |
vascular cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pocket protein p107 | hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | Mus musculus | ADP + phosphorylated pocket protein 107 | - |
? | |
ATP + pocket protein p107 | hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | Homo sapiens | ADP + phosphorylated pocket protein 107 | - |
? | |
ATP + pocket protein p107 | hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | Rattus norvegicus | ADP + phosphorylated pocket protein 107 | - |
? | |
ATP + pocket protein p107 | hyperphosphorylation by CDK/cyclin | Mus musculus | ADP + phosphorylated pocket protein 107 | - |
? | |
ATP + pocket protein p107 | hyperphosphorylation by CDK/cyclin | Homo sapiens | ADP + phosphorylated pocket protein 107 | - |
? | |
ATP + pocket protein p107 | hyperphosphorylation by CDK/cyclin | Rattus norvegicus | ADP + phosphorylated pocket protein 107 | - |
? | |
ATP + pocket protein p130 | hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | Mus musculus | ADP + phosphorylated pocket protein 130 | - |
? | |
ATP + pocket protein p130 | hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | Homo sapiens | ADP + phosphorylated pocket protein 130 | - |
? | |
ATP + pocket protein p130 | hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | Rattus norvegicus | ADP + phosphorylated pocket protein 130 | - |
? | |
ATP + pocket protein p130 | hyperphosphorylation by CDK/cyclin | Mus musculus | ADP + phosphorylated pocket protein 130 | - |
? | |
ATP + pocket protein p130 | hyperphosphorylation by CDK/cyclin | Homo sapiens | ADP + phosphorylated pocket protein 130 | - |
? | |
ATP + pocket protein p130 | hyperphosphorylation by CDK/cyclin | Rattus norvegicus | ADP + phosphorylated pocket protein 130 | - |
? | |
ATP + retinoblastoma protein | i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | Mus musculus | ADP + phosphorylated retinoblastoma protein | - |
? | |
ATP + retinoblastoma protein | i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | Homo sapiens | ADP + phosphorylated retinoblastoma protein | - |
? | |
ATP + retinoblastoma protein | i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis | Rattus norvegicus | ADP + phosphorylated retinoblastoma protein | - |
? | |
ATP + retinoblastoma protein | i.e. Rb protein, hyperphosphorylation by CDK/cyclin | Mus musculus | ADP + phosphorylated retinoblastoma protein | - |
? | |
ATP + retinoblastoma protein | i.e. Rb protein, hyperphosphorylation by CDK/cyclin | Homo sapiens | ADP + phosphorylated retinoblastoma protein | - |
? | |
ATP + retinoblastoma protein | i.e. Rb protein, hyperphosphorylation by CDK/cyclin | Rattus norvegicus | ADP + phosphorylated retinoblastoma protein | - |
? | |
additional information | CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview | Mus musculus | ? | - |
? | |
additional information | CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview | Homo sapiens | ? | - |
? | |
additional information | CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CDK | - |
Mus musculus |
CDK | - |
Homo sapiens |
CDK | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus | |
cyclin | regulatory subunit of CDK | Mus musculus | |
cyclin | regulatory subunit of CDK | Homo sapiens | |
cyclin | regulatory subunit of CDK | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00006 | - |
IC50 for CDK6 0.00006 mM | Rattus norvegicus | flavopiridol | |
0.000065 | - |
IC50 for CDK4 0.000065 mM | Rattus norvegicus | flavopiridol | |
0.0001 | - |
IC50 for CDK2 0.0001 mM | Rattus norvegicus | flavopiridol | |
0.00011 | 0.0003 | IC50 for CDK7 0.00011-0.0003 mM | Rattus norvegicus | flavopiridol | |
0.0005 | - |
inhibitor used in treatment of neointimal hyperplasia, IC50 for CDK1 is 0.0005 mM | Rattus norvegicus | flavopiridol | |
0.0005 | - |
IC50 for CDK2 0.0005 mM | Rattus norvegicus | CVT-313 | |
0.004 | - |
inhibitor used in treatment of neointimal hyperplasia, IC50 for CDK1 is 0.004 mM | Rattus norvegicus | CVT-313 | |
0.215 | - |
IC50 for CDK4 0.215 mM | Rattus norvegicus | CVT-313 |