BRENDA - Enzyme Database
show all sequences of 2.7.11.22

Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide

Kesavapany, S.; Li, B.S.; Amin, N.; Zheng, Y.L.; Grant, P.; Pant, H.C.; Biochim. Biophys. Acta 1697, 143-153 (2004)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
additional information
Cdk5 is activated by phosphorylation, integrin alpha1beta1 regulates phosphorylation of the axonal cytoskeleton protein
Homo sapiens
p25
regulatory subunit and activator of Cdk5, soluble, p35 is cleaved to p25 by calpain leading to hyperactivation of Cdk5
Mus musculus
p25
regulatory subunit and activator of Cdk5, soluble, p35 is cleaved to p25 by calpain leading to hyperactivation of Cdk5
Homo sapiens
p35
regulatory subunit and activator of Cdk5
Rattus norvegicus
p35
regulatory subunit and activator of Cdk5
Sus scrofa
p35
regulatory subunit and activator of Cdk5
Canis lupus familiaris
p35
regulatory subunit and activator of Cdk5, membrane-bound, in neuronal growth cones, p35 is cleaved to p25 by calpain leading to hyperactivation of Cdk5
Mus musculus
p35
regulatory subunit and activator of Cdk5, membrane-bound, in neuronal growth cones, p35 is cleaved to p25 by calpain leading to hyperactivation of Cdk5
Homo sapiens
p39
regulatory subunit and activator of Cdk5
Mus musculus
p39
regulatory subunit and activator of Cdk5
Homo sapiens
p39
regulatory subunit and activator of Cdk5
Rattus norvegicus
p39
regulatory subunit and activator of Cdk5
Sus scrofa
p39
regulatory subunit and activator of Cdk5
Canis lupus familiaris
Cloned(Commentary)
Cloned (Commentary)
Organism
Cdk5, DNA sequence determination and analysis
Drosophila melanogaster
Cdk5, DNA sequence determination and analysis
Mus musculus
Cdk5, DNA sequence determination and analysis
Rattus norvegicus
Cdk5, DNA sequence determination and analysis
Sus scrofa
Cdk5, DNA sequence determination and analysis
Saccharomyces cerevisiae
Cdk5, DNA sequence determination and analysis
Canis lupus familiaris
Cdk5, DNA sequence determination and analysis
Caenorhabditis elegans
Cdk5, DNA sequence determination and analysis
Doryteuthis pealeii
Cdk5, DNA sequence determination and analysis
Danio rerio
Cdk5, DNA sequence determination and analysis, co-expression of Cdk5 and p35 in HEK293 cells
Homo sapiens
Engineering
Protein Variants
Commentary
Organism
additional information
construction of Cdk5-knockout mutant mice that are embryonically lethal with very few viable at birth dying a few hours postpartum, p35 and p39 double-knockout mutant mice show a similar phenotype, the KO mice show higher ERK1/2 activity and increased neurofilament phosphorylation
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
integrin alpha1beta1 regulates phosphorylation of the axonal cytoskeleton protein, development of inhibitory peptides
Homo sapiens
roscovitine
-
Caenorhabditis elegans
roscovitine
-
Canis lupus familiaris
roscovitine
-
Danio rerio
roscovitine
-
Doryteuthis pealeii
roscovitine
-
Drosophila melanogaster
roscovitine
Cdk5 inhibition induces neurotransmitter release in vivo
Homo sapiens
roscovitine
-
Mus musculus
roscovitine
-
Rattus norvegicus
roscovitine
-
Saccharomyces cerevisiae
roscovitine
-
Sus scrofa
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Homo sapiens
5737
-
cytoskeleton
neuronal
Drosophila melanogaster
5856
-
cytoskeleton
neuronal
Mus musculus
5856
-
cytoskeleton
neuronal
Homo sapiens
5856
-
cytoskeleton
neuronal
Rattus norvegicus
5856
-
cytoskeleton
neuronal
Sus scrofa
5856
-
cytoskeleton
neuronal
Canis lupus familiaris
5856
-
cytoskeleton
neuronal
Caenorhabditis elegans
5856
-
cytoskeleton
neuronal
Doryteuthis pealeii
5856
-
cytoskeleton
neuronal
Danio rerio
5856
-
Golgi apparatus
-
Homo sapiens
5794
-
synapse
-
Homo sapiens
45202
-
synaptosome
-
Homo sapiens
-
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Canis lupus familiaris
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ATP + axonal cytoskeleton protein
Homo sapiens
regulated by integrin alpha1beta1
ADP + phosphorylated axonal cytoskeleton protein
-
-
?
ATP + c-Jun N-terminal kinase 3
Mus musculus
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
?
ATP + c-Jun N-terminal kinase 3
Homo sapiens
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
?
ATP + c-Jun N-terminal kinase 3
Rattus norvegicus
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
?
ATP + c-Jun N-terminal kinase 3
Sus scrofa
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
?
ATP + c-Jun N-terminal kinase 3
Canis lupus familiaris
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
?
ATP + c-Jun N-terminal kinase 3
Doryteuthis pealeii
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
?
ATP + Cprk
Homo sapiens
i.e. Cdk5/p35-regulated kinase
ADP + phosphorylated Cprk
-
-
?
ATP + dephosphin
Homo sapiens
Cdk5 regulates endocytosis involving dephosphin activity, overview
ADP + phosphorylated dephosphin
-
-
?
ATP + ErbB2
Mus musculus
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
ADP + phosphorylated ErbB2
-
-
?
ATP + ErbB2
Homo sapiens
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
ADP + phosphorylated ErbB2
-
-
?
ATP + ErbB3
Mus musculus
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
ADP + phosphorylated ErbB3
-
-
?
ATP + ErbB3
Homo sapiens
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
ADP + phosphorylated ErbB3
-
-
?
ATP + MEK1
Mus musculus
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
ADP + phosphorylated MEK1
-
-
?
ATP + MEK1
Homo sapiens
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
ADP + phosphorylated MEK1
-
-
?
ATP + MEK1
Rattus norvegicus
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
ADP + phosphorylated MEK1
-
-
?
ATP + MEK1
Sus scrofa
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
ADP + phosphorylated MEK1
-
-
?
ATP + MEK1
Canis lupus familiaris
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
ADP + phosphorylated MEK1
-
-
?
ATP + MEK1
Doryteuthis pealeii
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
ADP + phosphorylated MEK1
-
-
?
ATP + Munc-18
Homo sapiens
involved in regulation of exocytosis involving SNARE proteins, Munc-18 is required for mediating secretory responsesoverview
ADP + phosphorylated Munc-18
-
-
?
ATP + NF-H
Mus musculus
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-H
-
-
?
ATP + NF-H
Homo sapiens
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-H
-
-
?
ATP + NF-H
Sus scrofa
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-H
-
-
?
ATP + NF-H
Rattus norvegicus
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-H
-
-
?
ATP + NF-H
Canis lupus familiaris
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-H
-
-
?
ATP + NF-H
Doryteuthis pealeii
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-H
-
-
?
ATP + NF-M
Mus musculus
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-M
-
-
?
ATP + NF-M
Homo sapiens
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-M
-
-
?
ATP + NF-M
Rattus norvegicus
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-M
-
-
?
ATP + NF-M
Sus scrofa
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-M
-
-
?
ATP + NF-M
Canis lupus familiaris
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-M
-
-
?
ATP + NF-M
Doryteuthis pealeii
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-M
-
-
?
ATP + NR1 receptor
Homo sapiens
involved in synaptic transmission, overview
ADP + phosphorylated NR1 receptor
-
-
?
ATP + NR2 receptor
Homo sapiens
involved in synaptic transmission, phosphorylation of Ser1232 on the A subunit upregulates NMCAR activity, overview
ADP + phosphorylated NR2 receptor
-
-
?
ATP + tau protein
Mus musculus
hyperactivated Cdk5-p25
ADP + phosphorylated tau protein
-
-
?
ATP + tau protein
Homo sapiens
hyperactivated Cdk5-p25
ADP + phosphorylated tau protein
-
-
?
ATP + VGCC
Homo sapiens
a voltage-dependent calcium channel, phosphorylation within the intracellular loop of the channel inhibiting interaction with SNARE proteins, SNAP-25, and synaptotagmin I required for neurotransmitter release, overview
ADP + phosphorylated NR1 receptor
-
-
?
additional information
Drosophila melanogaster
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
?
-
-
?
additional information
Caenorhabditis elegans
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
?
-
-
?
additional information
Danio rerio
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
?
-
-
?
additional information
Mus musculus
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, and is critical for neuronal survival, deregulation of Cdk5 occurs in neurodegeneration
?
-
-
?
additional information
Rattus norvegicus
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
?
-
-
?
additional information
Sus scrofa
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
?
-
-
?
additional information
Canis lupus familiaris
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
?
-
-
?
additional information
Doryteuthis pealeii
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
?
-
-
?
additional information
Homo sapiens
Cdk5 regulation, overview, Cdk5 regulates endocytosis through association with amphiphysin and dynamin, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
?
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Caenorhabditis elegans
-
-
-
Canis lupus familiaris
-
-
-
Danio rerio
-
zebrafish
-
Doryteuthis pealeii
-
common squid
-
Drosophila melanogaster
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-
Sus scrofa
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
phosphoprotein
Cdk5 is regulated by reversible phosphorylation
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
brain
-
Sus scrofa
-
brain
-
Canis lupus familiaris
-
cerebellum
-
Homo sapiens
-
cerebral cortex
-
Mus musculus
-
nervous system
-
Drosophila melanogaster
-
nervous system
-
Mus musculus
-
nervous system
-
Homo sapiens
-
nervous system
-
Sus scrofa
-
nervous system
-
Canis lupus familiaris
-
nervous system
-
Caenorhabditis elegans
-
nervous system
-
Doryteuthis pealeii
-
nervous system
-
Danio rerio
-
neuroblastoma cell
-
Homo sapiens
-
neuron
-
Drosophila melanogaster
-
neuron
-
Mus musculus
-
neuron
-
Homo sapiens
-
neuron
-
Rattus norvegicus
-
neuron
-
Sus scrofa
-
neuron
-
Canis lupus familiaris
-
neuron
-
Caenorhabditis elegans
-
neuron
-
Doryteuthis pealeii
-
neuron
-
Danio rerio
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
ATP + axonal cytoskeleton protein
-
664179
Homo sapiens
ADP + phosphorylated axonal cytoskeleton protein
-
-
-
?
ATP + axonal cytoskeleton protein
regulated by integrin alpha1beta1
664179
Homo sapiens
ADP + phosphorylated axonal cytoskeleton protein
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
664179
Mus musculus
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
664179
Homo sapiens
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
664179
Rattus norvegicus
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
664179
Sus scrofa
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
664179
Canis lupus familiaris
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
664179
Doryteuthis pealeii
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation at Thr131
664179
Mus musculus
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation at Thr131
664179
Homo sapiens
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation at Thr131
664179
Rattus norvegicus
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation at Thr131
664179
Sus scrofa
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation at Thr131
664179
Canis lupus familiaris
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation at Thr131
664179
Doryteuthis pealeii
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + Cprk
i.e. Cdk5/p35-regulated kinase
664179
Homo sapiens
ADP + phosphorylated Cprk
-
-
-
?
ATP + dephosphin
-
664179
Homo sapiens
ADP + phosphorylated dephosphin
-
-
-
?
ATP + dephosphin
Cdk5 regulates endocytosis involving dephosphin activity, overview
664179
Homo sapiens
ADP + phosphorylated dephosphin
-
-
-
?
ATP + ErbB2
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
664179
Mus musculus
ADP + phosphorylated ErbB2
-
-
-
?
ATP + ErbB2
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
664179
Homo sapiens
ADP + phosphorylated ErbB2
-
-
-
?
ATP + ErbB2
phosphorylation at Thr871
664179
Mus musculus
ADP + phosphorylated ErbB2
-
-
-
?
ATP + ErbB2
phosphorylation at Thr871
664179
Homo sapiens
ADP + phosphorylated ErbB2
-
-
-
?
ATP + ErbB3
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
664179
Mus musculus
ADP + phosphorylated ErbB3
-
-
-
?
ATP + ErbB3
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
664179
Homo sapiens
ADP + phosphorylated ErbB3
-
-
-
?
ATP + ErbB3
phosphorylation at Ser1120
664179
Mus musculus
ADP + phosphorylated ErbB3
-
-
-
?
ATP + ErbB3
phosphorylation at Ser1120
664179
Homo sapiens
ADP + phosphorylated ErbB3
-
-
-
?
ATP + MEK1
-
664179
Homo sapiens
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
-
664179
Rattus norvegicus
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
-
664179
Sus scrofa
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
-
664179
Canis lupus familiaris
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
-
664179
Doryteuthis pealeii
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
664179
Mus musculus
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
664179
Homo sapiens
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
664179
Rattus norvegicus
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
664179
Sus scrofa
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
664179
Canis lupus familiaris
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
664179
Doryteuthis pealeii
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
phosphorylation at Thr286
664179
Mus musculus
ADP + phosphorylated MEK1
-
-
-
?
ATP + Munc-18
-
664179
Homo sapiens
ADP + phosphorylated Munc-18
-
-
-
?
ATP + Munc-18
involved in regulation of exocytosis involving SNARE proteins, Munc-18 is required for mediating secretory responsesoverview
664179
Homo sapiens
ADP + phosphorylated Munc-18
-
-
-
?
ATP + NF-H
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Mus musculus
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Homo sapiens
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Sus scrofa
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Rattus norvegicus
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Canis lupus familiaris
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Doryteuthis pealeii
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats
664179
Mus musculus
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats
664179
Rattus norvegicus
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats
664179
Sus scrofa
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats
664179
Canis lupus familiaris
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats
664179
Doryteuthis pealeii
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats, hyperactivated Cdk5-p25
664179
Homo sapiens
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Mus musculus
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Homo sapiens
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Rattus norvegicus
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Sus scrofa
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Canis lupus familiaris
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Doryteuthis pealeii
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats
664179
Mus musculus
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats
664179
Rattus norvegicus
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats
664179
Sus scrofa
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats
664179
Canis lupus familiaris
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats
664179
Doryteuthis pealeii
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats, hyperactivated Cdk5-p25
664179
Homo sapiens
ADP + phosphorylated NF-M
-
-
-
?
ATP + NR1 receptor
-
664179
Homo sapiens
ADP + phosphorylated NR1 receptor
-
-
-
?
ATP + NR1 receptor
involved in synaptic transmission, overview
664179
Homo sapiens
ADP + phosphorylated NR1 receptor
-
-
-
?
ATP + NR2 receptor
involved in synaptic transmission, phosphorylation of Ser1232 on the A subunit upregulates NMCAR activity, overview
664179
Homo sapiens
ADP + phosphorylated NR2 receptor
-
-
-
?
ATP + NR2 receptor
with phosphorylation sites on both, A and B subunits, e.g. Ser1232 on the A subunit
664179
Homo sapiens
ADP + phosphorylated NR2 receptor
-
-
-
?
ATP + tau protein
hyperactivated Cdk5-p25
664179
Mus musculus
ADP + phosphorylated tau protein
-
-
-
?
ATP + tau protein
hyperactivated Cdk5-p25
664179
Homo sapiens
ADP + phosphorylated tau protein
-
-
-
?
ATP + VGCC
a voltage-dependent calcium channel, phosphorylation within the intracellular loop of the channel inhibiting interaction with SNARE proteins, SNAP-25, and synaptotagmin I required for neurotransmitter release, overview
664179
Homo sapiens
ADP + phosphorylated NR1 receptor
-
-
-
?
ATP + VGCC
a voltage-dependent calcium channel, phosphorylation within the intracellular loop of the channel
664179
Homo sapiens
ADP + phosphorylated NR1 receptor
-
-
-
?
additional information
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
664179
Drosophila melanogaster
?
-
-
-
?
additional information
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
664179
Caenorhabditis elegans
?
-
-
-
?
additional information
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
664179
Danio rerio
?
-
-
-
?
additional information
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, and is critical for neuronal survival, deregulation of Cdk5 occurs in neurodegeneration
664179
Mus musculus
?
-
-
-
?
additional information
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
664179
Rattus norvegicus
?
-
-
-
?
additional information
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
664179
Sus scrofa
?
-
-
-
?
additional information
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
664179
Canis lupus familiaris
?
-
-
-
?
additional information
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
664179
Doryteuthis pealeii
?
-
-
-
?
additional information
Cdk5 regulation, overview, Cdk5 regulates endocytosis through association with amphiphysin and dynamin, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
664179
Homo sapiens
?
-
-
-
?
additional information
Cdk5 associates with amphiphysin and dynamin
664179
Homo sapiens
?
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
Cdk5
-
Drosophila melanogaster
Cdk5
-
Mus musculus
Cdk5
-
Homo sapiens
Cdk5
-
Rattus norvegicus
Cdk5
-
Sus scrofa
Cdk5
-
Saccharomyces cerevisiae
Cdk5
-
Canis lupus familiaris
Cdk5
-
Caenorhabditis elegans
Cdk5
-
Doryteuthis pealeii
Cdk5
-
Danio rerio
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Drosophila melanogaster
ATP
-
Mus musculus
ATP
-
Homo sapiens
ATP
-
Rattus norvegicus
ATP
-
Sus scrofa
ATP
-
Saccharomyces cerevisiae
ATP
-
Canis lupus familiaris
ATP
-
Caenorhabditis elegans
ATP
-
Doryteuthis pealeii
ATP
-
Danio rerio
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
additional information
Cdk5 is activated by phosphorylation, integrin alpha1beta1 regulates phosphorylation of the axonal cytoskeleton protein
Homo sapiens
p25
regulatory subunit and activator of Cdk5, soluble, p35 is cleaved to p25 by calpain leading to hyperactivation of Cdk5
Mus musculus
p25
regulatory subunit and activator of Cdk5, soluble, p35 is cleaved to p25 by calpain leading to hyperactivation of Cdk5
Homo sapiens
p35
regulatory subunit and activator of Cdk5
Rattus norvegicus
p35
regulatory subunit and activator of Cdk5
Sus scrofa
p35
regulatory subunit and activator of Cdk5
Canis lupus familiaris
p35
regulatory subunit and activator of Cdk5, membrane-bound, in neuronal growth cones, p35 is cleaved to p25 by calpain leading to hyperactivation of Cdk5
Mus musculus
p35
regulatory subunit and activator of Cdk5, membrane-bound, in neuronal growth cones, p35 is cleaved to p25 by calpain leading to hyperactivation of Cdk5
Homo sapiens
p39
regulatory subunit and activator of Cdk5
Mus musculus
p39
regulatory subunit and activator of Cdk5
Homo sapiens
p39
regulatory subunit and activator of Cdk5
Rattus norvegicus
p39
regulatory subunit and activator of Cdk5
Sus scrofa
p39
regulatory subunit and activator of Cdk5
Canis lupus familiaris
Cloned(Commentary) (protein specific)
Commentary
Organism
Cdk5, DNA sequence determination and analysis
Drosophila melanogaster
Cdk5, DNA sequence determination and analysis
Mus musculus
Cdk5, DNA sequence determination and analysis
Rattus norvegicus
Cdk5, DNA sequence determination and analysis
Sus scrofa
Cdk5, DNA sequence determination and analysis
Saccharomyces cerevisiae
Cdk5, DNA sequence determination and analysis
Canis lupus familiaris
Cdk5, DNA sequence determination and analysis
Caenorhabditis elegans
Cdk5, DNA sequence determination and analysis
Doryteuthis pealeii
Cdk5, DNA sequence determination and analysis
Danio rerio
Cdk5, DNA sequence determination and analysis, co-expression of Cdk5 and p35 in HEK293 cells
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Drosophila melanogaster
ATP
-
Mus musculus
ATP
-
Homo sapiens
ATP
-
Rattus norvegicus
ATP
-
Sus scrofa
ATP
-
Saccharomyces cerevisiae
ATP
-
Canis lupus familiaris
ATP
-
Caenorhabditis elegans
ATP
-
Doryteuthis pealeii
ATP
-
Danio rerio
Engineering (protein specific)
Protein Variants
Commentary
Organism
additional information
construction of Cdk5-knockout mutant mice that are embryonically lethal with very few viable at birth dying a few hours postpartum, p35 and p39 double-knockout mutant mice show a similar phenotype, the KO mice show higher ERK1/2 activity and increased neurofilament phosphorylation
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
integrin alpha1beta1 regulates phosphorylation of the axonal cytoskeleton protein, development of inhibitory peptides
Homo sapiens
roscovitine
-
Drosophila melanogaster
roscovitine
-
Mus musculus
roscovitine
-
Rattus norvegicus
roscovitine
-
Sus scrofa
roscovitine
-
Saccharomyces cerevisiae
roscovitine
-
Canis lupus familiaris
roscovitine
-
Caenorhabditis elegans
roscovitine
-
Doryteuthis pealeii
roscovitine
-
Danio rerio
roscovitine
Cdk5 inhibition induces neurotransmitter release in vivo
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Homo sapiens
5737
-
cytoskeleton
neuronal
Drosophila melanogaster
5856
-
cytoskeleton
neuronal
Mus musculus
5856
-
cytoskeleton
neuronal
Homo sapiens
5856
-
cytoskeleton
neuronal
Rattus norvegicus
5856
-
cytoskeleton
neuronal
Sus scrofa
5856
-
cytoskeleton
neuronal
Canis lupus familiaris
5856
-
cytoskeleton
neuronal
Caenorhabditis elegans
5856
-
cytoskeleton
neuronal
Doryteuthis pealeii
5856
-
cytoskeleton
neuronal
Danio rerio
5856
-
Golgi apparatus
-
Homo sapiens
5794
-
synapse
-
Homo sapiens
45202
-
synaptosome
-
Homo sapiens
-
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Canis lupus familiaris
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ATP + axonal cytoskeleton protein
Homo sapiens
regulated by integrin alpha1beta1
ADP + phosphorylated axonal cytoskeleton protein
-
-
?
ATP + c-Jun N-terminal kinase 3
Mus musculus
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
?
ATP + c-Jun N-terminal kinase 3
Homo sapiens
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
?
ATP + c-Jun N-terminal kinase 3
Rattus norvegicus
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
?
ATP + c-Jun N-terminal kinase 3
Sus scrofa
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
?
ATP + c-Jun N-terminal kinase 3
Canis lupus familiaris
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
?
ATP + c-Jun N-terminal kinase 3
Doryteuthis pealeii
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
?
ATP + Cprk
Homo sapiens
i.e. Cdk5/p35-regulated kinase
ADP + phosphorylated Cprk
-
-
?
ATP + dephosphin
Homo sapiens
Cdk5 regulates endocytosis involving dephosphin activity, overview
ADP + phosphorylated dephosphin
-
-
?
ATP + ErbB2
Mus musculus
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
ADP + phosphorylated ErbB2
-
-
?
ATP + ErbB2
Homo sapiens
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
ADP + phosphorylated ErbB2
-
-
?
ATP + ErbB3
Mus musculus
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
ADP + phosphorylated ErbB3
-
-
?
ATP + ErbB3
Homo sapiens
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
ADP + phosphorylated ErbB3
-
-
?
ATP + MEK1
Mus musculus
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
ADP + phosphorylated MEK1
-
-
?
ATP + MEK1
Homo sapiens
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
ADP + phosphorylated MEK1
-
-
?
ATP + MEK1
Rattus norvegicus
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
ADP + phosphorylated MEK1
-
-
?
ATP + MEK1
Sus scrofa
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
ADP + phosphorylated MEK1
-
-
?
ATP + MEK1
Canis lupus familiaris
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
ADP + phosphorylated MEK1
-
-
?
ATP + MEK1
Doryteuthis pealeii
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
ADP + phosphorylated MEK1
-
-
?
ATP + Munc-18
Homo sapiens
involved in regulation of exocytosis involving SNARE proteins, Munc-18 is required for mediating secretory responsesoverview
ADP + phosphorylated Munc-18
-
-
?
ATP + NF-H
Mus musculus
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-H
-
-
?
ATP + NF-H
Homo sapiens
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-H
-
-
?
ATP + NF-H
Sus scrofa
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-H
-
-
?
ATP + NF-H
Rattus norvegicus
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-H
-
-
?
ATP + NF-H
Canis lupus familiaris
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-H
-
-
?
ATP + NF-H
Doryteuthis pealeii
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-H
-
-
?
ATP + NF-M
Mus musculus
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-M
-
-
?
ATP + NF-M
Homo sapiens
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-M
-
-
?
ATP + NF-M
Rattus norvegicus
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-M
-
-
?
ATP + NF-M
Sus scrofa
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-M
-
-
?
ATP + NF-M
Canis lupus familiaris
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-M
-
-
?
ATP + NF-M
Doryteuthis pealeii
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
ADP + phosphorylated NF-M
-
-
?
ATP + NR1 receptor
Homo sapiens
involved in synaptic transmission, overview
ADP + phosphorylated NR1 receptor
-
-
?
ATP + NR2 receptor
Homo sapiens
involved in synaptic transmission, phosphorylation of Ser1232 on the A subunit upregulates NMCAR activity, overview
ADP + phosphorylated NR2 receptor
-
-
?
ATP + tau protein
Mus musculus
hyperactivated Cdk5-p25
ADP + phosphorylated tau protein
-
-
?
ATP + tau protein
Homo sapiens
hyperactivated Cdk5-p25
ADP + phosphorylated tau protein
-
-
?
ATP + VGCC
Homo sapiens
a voltage-dependent calcium channel, phosphorylation within the intracellular loop of the channel inhibiting interaction with SNARE proteins, SNAP-25, and synaptotagmin I required for neurotransmitter release, overview
ADP + phosphorylated NR1 receptor
-
-
?
additional information
Drosophila melanogaster
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
?
-
-
?
additional information
Caenorhabditis elegans
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
?
-
-
?
additional information
Danio rerio
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
?
-
-
?
additional information
Mus musculus
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, and is critical for neuronal survival, deregulation of Cdk5 occurs in neurodegeneration
?
-
-
?
additional information
Rattus norvegicus
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
?
-
-
?
additional information
Sus scrofa
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
?
-
-
?
additional information
Canis lupus familiaris
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
?
-
-
?
additional information
Doryteuthis pealeii
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
?
-
-
?
additional information
Homo sapiens
Cdk5 regulation, overview, Cdk5 regulates endocytosis through association with amphiphysin and dynamin, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
?
-
-
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
phosphoprotein
Cdk5 is regulated by reversible phosphorylation
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
brain
-
Sus scrofa
-
brain
-
Canis lupus familiaris
-
cerebellum
-
Homo sapiens
-
cerebral cortex
-
Mus musculus
-
nervous system
-
Drosophila melanogaster
-
nervous system
-
Mus musculus
-
nervous system
-
Homo sapiens
-
nervous system
-
Sus scrofa
-
nervous system
-
Canis lupus familiaris
-
nervous system
-
Caenorhabditis elegans
-
nervous system
-
Doryteuthis pealeii
-
nervous system
-
Danio rerio
-
neuroblastoma cell
-
Homo sapiens
-
neuron
-
Drosophila melanogaster
-
neuron
-
Mus musculus
-
neuron
-
Homo sapiens
-
neuron
-
Rattus norvegicus
-
neuron
-
Sus scrofa
-
neuron
-
Canis lupus familiaris
-
neuron
-
Caenorhabditis elegans
-
neuron
-
Doryteuthis pealeii
-
neuron
-
Danio rerio
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
ATP + axonal cytoskeleton protein
-
664179
Homo sapiens
ADP + phosphorylated axonal cytoskeleton protein
-
-
-
?
ATP + axonal cytoskeleton protein
regulated by integrin alpha1beta1
664179
Homo sapiens
ADP + phosphorylated axonal cytoskeleton protein
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
664179
Mus musculus
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
664179
Homo sapiens
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
664179
Rattus norvegicus
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
664179
Sus scrofa
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
664179
Canis lupus familiaris
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
664179
Doryteuthis pealeii
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation at Thr131
664179
Mus musculus
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation at Thr131
664179
Homo sapiens
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation at Thr131
664179
Rattus norvegicus
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation at Thr131
664179
Sus scrofa
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation at Thr131
664179
Canis lupus familiaris
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + c-Jun N-terminal kinase 3
i.e. JNK3, phosphorylation at Thr131
664179
Doryteuthis pealeii
ADP + phosphorylated c-Jun N-terminal kinase 3
-
-
-
?
ATP + Cprk
i.e. Cdk5/p35-regulated kinase
664179
Homo sapiens
ADP + phosphorylated Cprk
-
-
-
?
ATP + dephosphin
-
664179
Homo sapiens
ADP + phosphorylated dephosphin
-
-
-
?
ATP + dephosphin
Cdk5 regulates endocytosis involving dephosphin activity, overview
664179
Homo sapiens
ADP + phosphorylated dephosphin
-
-
-
?
ATP + ErbB2
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
664179
Mus musculus
ADP + phosphorylated ErbB2
-
-
-
?
ATP + ErbB2
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
664179
Homo sapiens
ADP + phosphorylated ErbB2
-
-
-
?
ATP + ErbB2
phosphorylation at Thr871
664179
Mus musculus
ADP + phosphorylated ErbB2
-
-
-
?
ATP + ErbB2
phosphorylation at Thr871
664179
Homo sapiens
ADP + phosphorylated ErbB2
-
-
-
?
ATP + ErbB3
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
664179
Mus musculus
ADP + phosphorylated ErbB3
-
-
-
?
ATP + ErbB3
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
664179
Homo sapiens
ADP + phosphorylated ErbB3
-
-
-
?
ATP + ErbB3
phosphorylation at Ser1120
664179
Mus musculus
ADP + phosphorylated ErbB3
-
-
-
?
ATP + ErbB3
phosphorylation at Ser1120
664179
Homo sapiens
ADP + phosphorylated ErbB3
-
-
-
?
ATP + MEK1
-
664179
Homo sapiens
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
-
664179
Rattus norvegicus
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
-
664179
Sus scrofa
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
-
664179
Canis lupus familiaris
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
-
664179
Doryteuthis pealeii
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
664179
Mus musculus
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
664179
Homo sapiens
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
664179
Rattus norvegicus
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
664179
Sus scrofa
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
664179
Canis lupus familiaris
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
664179
Doryteuthis pealeii
ADP + phosphorylated MEK1
-
-
-
?
ATP + MEK1
phosphorylation at Thr286
664179
Mus musculus
ADP + phosphorylated MEK1
-
-
-
?
ATP + Munc-18
-
664179
Homo sapiens
ADP + phosphorylated Munc-18
-
-
-
?
ATP + Munc-18
involved in regulation of exocytosis involving SNARE proteins, Munc-18 is required for mediating secretory responsesoverview
664179
Homo sapiens
ADP + phosphorylated Munc-18
-
-
-
?
ATP + NF-H
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Mus musculus
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Homo sapiens
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Sus scrofa
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Rattus norvegicus
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Canis lupus familiaris
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Doryteuthis pealeii
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats
664179
Mus musculus
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats
664179
Rattus norvegicus
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats
664179
Sus scrofa
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats
664179
Canis lupus familiaris
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats
664179
Doryteuthis pealeii
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-H
neurofilament protein, phosphorylation at the KSP repeats, hyperactivated Cdk5-p25
664179
Homo sapiens
ADP + phosphorylated NF-H
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Mus musculus
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Homo sapiens
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Rattus norvegicus
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Sus scrofa
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Canis lupus familiaris
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
664179
Doryteuthis pealeii
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats
664179
Mus musculus
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats
664179
Rattus norvegicus
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats
664179
Sus scrofa
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats
664179
Canis lupus familiaris
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats
664179
Doryteuthis pealeii
ADP + phosphorylated NF-M
-
-
-
?
ATP + NF-M
neurofilament protein, phosphorylation at the KSP repeats, hyperactivated Cdk5-p25
664179
Homo sapiens
ADP + phosphorylated NF-M
-
-
-
?
ATP + NR1 receptor
-
664179
Homo sapiens
ADP + phosphorylated NR1 receptor
-
-
-
?
ATP + NR1 receptor
involved in synaptic transmission, overview
664179
Homo sapiens
ADP + phosphorylated NR1 receptor
-
-
-
?
ATP + NR2 receptor
involved in synaptic transmission, phosphorylation of Ser1232 on the A subunit upregulates NMCAR activity, overview
664179
Homo sapiens
ADP + phosphorylated NR2 receptor
-
-
-
?
ATP + NR2 receptor
with phosphorylation sites on both, A and B subunits, e.g. Ser1232 on the A subunit
664179
Homo sapiens
ADP + phosphorylated NR2 receptor
-
-
-
?
ATP + tau protein
hyperactivated Cdk5-p25
664179
Mus musculus
ADP + phosphorylated tau protein
-
-
-
?
ATP + tau protein
hyperactivated Cdk5-p25
664179
Homo sapiens
ADP + phosphorylated tau protein
-
-
-
?
ATP + VGCC
a voltage-dependent calcium channel, phosphorylation within the intracellular loop of the channel inhibiting interaction with SNARE proteins, SNAP-25, and synaptotagmin I required for neurotransmitter release, overview
664179
Homo sapiens
ADP + phosphorylated NR1 receptor
-
-
-
?
ATP + VGCC
a voltage-dependent calcium channel, phosphorylation within the intracellular loop of the channel
664179
Homo sapiens
ADP + phosphorylated NR1 receptor
-
-
-
?
additional information
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
664179
Drosophila melanogaster
?
-
-
-
?
additional information
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
664179
Caenorhabditis elegans
?
-
-
-
?
additional information
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
664179
Danio rerio
?
-
-
-
?
additional information
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, and is critical for neuronal survival, deregulation of Cdk5 occurs in neurodegeneration
664179
Mus musculus
?
-
-
-
?
additional information
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
664179
Rattus norvegicus
?
-
-
-
?
additional information
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
664179
Sus scrofa
?
-
-
-
?
additional information
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
664179
Canis lupus familiaris
?
-
-
-
?
additional information
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
664179
Doryteuthis pealeii
?
-
-
-
?
additional information
Cdk5 regulation, overview, Cdk5 regulates endocytosis through association with amphiphysin and dynamin, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
664179
Homo sapiens
?
-
-
-
?
additional information
Cdk5 associates with amphiphysin and dynamin
664179
Homo sapiens
?
-
-
-
?
Other publictions for EC 2.7.11.22
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737950
Harashima
Modulation of plant growth in ...
Arabidopsis thaliana
BMC Plant Biol.
16
209
2016
-
-
-
-
-
-
1
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
23
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
23
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737994
Yan
Cdk3, a conjugation-specific c ...
Tetrahymena thermophila, Tetrahymena thermophila CU427
Cell Cycle
15
2506-2514
2016
1
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
738159
Vymetalova
5-Substituted 3-isopropyl-7-[4 ...
Homo sapiens
Eur. J. Med. Chem.
110
291-301
2016
-
-
1
-
-
-
30
-
-
-
-
1
-
1
-
-
1
-
-
4
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
44
-
-
1
-
-
-
-
44
30
-
-
-
-
-
1
-
-
-
1
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739062
Petrone
Identification of candidate cy ...
Homo sapiens
Mol. Cell. Proteomics
15
2448-2461
2016
1
-
1
-
-
-
2
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737949
Huysman
Functional characterization of ...
Phaeodactylum tricornutum
BMC Plant Biol.
15
86
2015
-
-
-
-
-
-
-
-
1
-
-
-
-
17
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
739059
Liang
Characterization of human cycl ...
Homo sapiens
Mol. Cell. Biol.
35
928-938
2015
-
-
-
-
-
-
-
-
-
-
-
2
-
5
-
-
-
-
-
2
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
4
4
-
-
-
737959
Albert
Characterization of molecular ...
Homo sapiens
Br. J. Pharmacol.
171
55-68
2014
-
-
-
-
-
-
4
-
-
-
-
1
-
1
-
-
-
-
-
5
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
4
4
-
-
-
-
-
1
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723176
Menoyo
Phosphate-activated cyclin-dep ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Mol. Cell. Biol.
33
1273-1284
2013
1
-
1
-
-
-
-
-
-
-
-
2
-
70
-
-
1
-
-
-
-
-
4
-
4
-
-
-
-
-
-
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
723178
Hizli
Phosphorylation of eukaryotic ...
Homo sapiens
Mol. Cell. Biol.
33
596-604
2013
2
-
1
-
-
-
-
-
3
-
-
2
-
1
-
-
-
-
-
1
-
-
5
-
3
-
-
-
-
1
-
-
2
-
-
-
2
-
1
2
-
-
-
-
-
-
-
3
-
-
2
-
-
-
-
-
1
-
-
5
-
-
-
-
-
1
-
-
-
-
2
2
-
-
-
723513
Abreu
Site-specific phosphorylation ...
Saccharomyces cerevisiae
PLoS Genet.
9
e1003310
2013
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
723745
Chen
Determination of kinetic param ...
Homo sapiens
Rapid Commun. Mass Spectrom.
27
985-992
2013
1
-
-
-
-
-
10
2
-
1
-
-
-
1
-
-
-
-
-
1
-
-
1
-
2
1
-
-
-
1
-
-
1
-
-
9
1
-
-
1
-
-
-
9
10
-
2
-
1
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
738597
Zheng
New structural insights into p ...
Saccharomyces cerevisiae
J. Biol. Chem.
288
30682-30692
2013
1
-
1
1
-
-
-
-
-
-
1
9
-
4
-
-
1
-
-
-
-
-
10
1
2
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
1
9
-
-
-
1
-
-
-
-
10
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738935
Fujino
Crystal structure of human cyc ...
Homo sapiens
J. Synchrotron Radiat.
20
905-909
2013
-
-
1
1
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739471
Monnerat
Identification and functional ...
Trypanosoma brucei, Trypanosoma brucei Lister 427
PLoS ONE
8
e67327
2013
1
-
-
-
1
-
-
-
-
-
1
4
-
15
-
-
-
-
-
-
-
-
4
1
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
1
4
-
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
721817
Malmstroem
Synthesis and structure-activi ...
Homo sapiens
Bioorg. Med. Chem. Lett.
22
5919-5923
2012
4
1
-
1
-
-
24
-
-
1
-
-
-
1
-
-
-
-
-
2
-
-
1
-
4
-
-
-
-
1
-
-
1
-
-
29
4
1
-
1
1
-
-
29
24
-
-
-
1
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
721986
Leitch
Cyclin-dependent kinases 7 and ...
Homo sapiens
Cell Death Differ.
19
1950-1961
2012
2
-
-
-
-
-
5
-
-
-
-
1
-
4
-
-
-
-
-
1
-
-
1
-
4
-
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
5
-
-
-
-
-
1
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Doxycycline regulated inductio ...
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Physcomitrella cyclin-dependen ...
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Polyphenol-rich extract from m ...
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Identification of substrates f ...
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Aggarwal
Nuclear cyclin D1/CDK4 kinase ...
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Chen
Mechanism of action of SNS-032 ...
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Buck
The cyclin-dependent kinase in ...
Caenorhabditis elegans
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Jhou
Inhibition of cyclin-dependent ...
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Bonvini
The effect of the cyclin-depen ...
Homo sapiens
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Hao
The neuroprotective effects of ...
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Kinetic studies of Cdk5/p25 ki ...
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2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
691105
Fukasawa
P53, cyclin-dependent kinase a ...
Mus musculus
Biochim. Biophys. Acta
1786
15-23
2008
1
-
-
-
-
-
3
-
1
-
-
1
-
1
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-
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1
-
1
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-
-
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-
1
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-
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1
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-
1
-
-
-
-
3
-
-
1
-
-
1
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
691272
Lee
Synthesis and biological evalu ...
Homo sapiens
Bioorg. Med. Chem. Lett.
18
2292-2295
2008
-
-
-
-
-
-
29
-
-
-
-
-
-
3
-
-
-
-
-
12
-
-
3
-
3
-
-
-
-
-
-
-
3
-
-
71
-
-
-
3
-
-
-
71
87
-
-
-
-
-
-
-
-
-
-
-
12
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691293
Finlay
Imidazole piperazines: SAR and ...
Homo sapiens
Bioorg. Med. Chem. Lett.
18
4442-4446
2008
-
-
-
-
-
-
13
-
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2
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-
-
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-
1
-
-
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-
1
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-
12
-
-
-
1
-
-
-
12
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691302
Anderson
Imidazoles: SAR and developmen ...
Homo sapiens
Bioorg. Med. Chem. Lett.
18
5487-5492
2008
-
-
-
-
-
-
25
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
-
-
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3
-
-
36
-
-
-
3
-
-
-
36
50
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691554
Chen
Involvement of calpain and p25 ...
Rattus norvegicus
Brain Res.
1200
99-106
2008
4
-
-
-
-
-
-
-
1
-
-
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-
1
-
-
-
-
-
2
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1
-
2
-
-
-
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2
-
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4
-
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691982
Peng
The cyclin-dependent kinase Cd ...
Saccharomyces cerevisiae
Dev. Cell
15
478-485
2008
-
-
-
-
-
-
-
-
1
-
-
1
-
3
-
-
-
-
-
-
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2
-
1
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-
-
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1
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-
-
-
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1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691988
Sen
The potential role of cyclin-d ...
Mus musculus
Dev. Neurosci.
30
96-104
2008
2
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
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2
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4
-
2
-
-
-
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1
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2
1
-
1
-
-
-
-
-
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-
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-
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2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693698
Liem
Cyclin-dependent kinase 2 sign ...
Mus musculus
J. Mol. Cell. Cardiol.
45
610-616
2008
1
1
-
-
-
-
-
-
-
-
-
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2
-
-
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1
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1
-
2
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1
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-
1
1
-
1
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-
-
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-
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-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693747
Paoletti
Dopaminergic and glutamatergic ...
Mus musculus, Homo sapiens
J. Neurosci.
28
10090-10101
2008
2
2
-
-
-
-
2
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
6
-
4
-
-
-
-
-
-
-
2
-
-
-
2
2
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693758
Amin
Cyclin-dependent kinase 5 phos ...
Mus musculus, Rattus norvegicus
J. Neurosci.
28
3631-3643
2008
2
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
3
-
-
4
-
4
-
-
-
-
-
-
-
2
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693762
Cheung
Cyclin-dependent kinase 5 supp ...
Mus musculus
J. Neurosci.
28
4872-4877
2008
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
-
-
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-
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-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693779
Hsiao
N-acetylcysteine prevents beta ...
Rattus norvegicus
J. Neurosci. Res.
86
2685-2695
2008
2
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694081
Kono
G1/S cyclin-dependent kinase r ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae YOC3388
Mol. Biol. Cell
19
1763-1771
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
2
-
3
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
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-
-
-
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-
-
-
-
-
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-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694150
Sabo
Acetylation of conserved lysin ...
Homo sapiens
Mol. Cell. Biol.
28
2201-2212
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694187
Lewis
Phosphorylation of steroidogen ...
Homo sapiens, Mus musculus
Mol. Endocrinol.
22
91-104
2008
-
-
-
-
2
-
2
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
2
-
4
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694491
Costoya
Cyclin-dependent kinase antago ...
Homo sapiens
Oncogene
27
3789-3796
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
2
-
3
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694675
Kitsios
A cyclin-dependent protein kin ...
Arabidopsis thaliana
Plant J.
54
220-235
2008
-
-
-
-
-
-
-
-
3
-
-
-
-
8
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695013
Bartova
Functional flexibility of huma ...
Homo sapiens
Protein Sci.
17
22-33
2008
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
3
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695048
Chen
A novel binding pocket of cycl ...
Homo sapiens
Proteins
74
122-132
2008
-
-
-
-
2
-
6
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
2
-
-
-
1
-
2
-
2
8
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695133
Hume
Phosphorylation of retinoblast ...
Human betaherpesvirus 5
Science
320
797-799
2008
-
-
-
-
2
-
1
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695204
Wang
Involvement of cyclin-dependen ...
Rattus norvegicus
Toxicology
248
1-7
2008
2
-
-
-
-
-
1
-
2
-
-
-
-
2
-
-
-
-
-
3
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695232
Wang
Cyclin-dependent kinase 9: a k ...
Homo sapiens
Trends Pharmacol. Sci.
29
302-313
2008
1
1
-
-
-
-
17
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
2
-
-
-
1
1
-
2
-
-
-
-
17
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709510
Wang
Functions, regulation and cell ...
Arabidopsis thaliana
J. Microsc.
231
234-246
2008
-
-
-
-
-
-
7
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
710113
Ivanov
(R)-roscovitine, a cyclin-depe ...
Rattus norvegicus
Neuroscience
156
277-288
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
5
-
-
-
-
-
4
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677617
Choi
Cyclin-dependent protein kinas ...
Homo sapiens
Apoptosis
12
1229-1241
2007
2
1
1
-
1
-
1
-
1
-
-
-
-
4
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
2
1
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678926
Gu
Identifying allosteric fluctua ...
Homo sapiens
BMC Bioinformatics
8
45
2007
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
1
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680023
Ikui
Cyclin and cyclin-dependent ki ...
Saccharomyces cerevisiae
Genetics
175
1011-1022
2007
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
14
-
2
-
-
-
-
-
-
-
2
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
14
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680111
Baatout
Histone H1 and cdk1 kinase act ...
Mus musculus
In Vivo
21
571-582
2007
-
1
-
-
-
-
1
-
-
-
-
-
-
5
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680759
Avraham
Phosphorylation of Parkin by t ...
Homo sapiens, Rattus norvegicus
J. Biol. Chem.
282
12842-12850
2007
2
1
2
-
-
-
4
-
-
-
-
1
-
5
-
-
-
-
-
4
-
-
4
-
6
1
-
-
-
-
-
-
1
-
-
-
2
1
2
1
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
4
-
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
681873
Yamasaki
Sensitivity of breast cancer c ...
Homo sapiens
Mol. Cancer Ther.
6
2168-2177
2007
-
-
1
-
-
-
3
-
-
-
-
-
-
2
-
-
1
-
-
20
-
-
2
-
7
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
5
-
-
-
-
-
-
-
-
-
1
-
20
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681881
Larochelle
Requirements for Cdk7 in the a ...
Homo sapiens
Mol. Cell
25
839-850
2007
1
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2
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681935
Kino
Cyclin-dependent kinase 5 diff ...
Rattus norvegicus
Mol. Endocrinol.
21
1552-1568
2007
2
1
1
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1
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1
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1
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682130
Kanungo
Cloning and characterization o ...
Danio rerio
Neurosci. Lett.
412
233-238
2007
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1
1
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1
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6
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1
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682384
Harashima
Phosphorylation of threonine 1 ...
Nicotiana tabacum, Arabidopsis thaliana
Plant J.
52
435-448
2007
4
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1
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8
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2
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2
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682579
Shu
Functional characterization of ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
104
9248-9253
2007
1
1
2
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2
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4
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2
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4
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1
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3
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682872
Moore
Cyclin dependent kinase 2 and ...
Homo sapiens, Rattus norvegicus
Steroids
72
202-209
2007
4
1
1
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1
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6
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2
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4
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8
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8
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691256
Chen
Synthesis and activity of quin ...
Homo sapiens
Bioorg. Med. Chem. Lett.
17
2134-2138
2007
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35
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6
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35
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6
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691430
Cheung
The roles of cyclin-dependent ...
Mus musculus
Biotechnol. J.
2
949-957
2007
2
-
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1
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2
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14
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2
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1
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14
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691679
Meuer
Cyclin-dependent kinase 5 is a ...
Rattus norvegicus
Cell Death Differ.
14
651-661
2007
-
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1
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1
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2
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691801
De Vivo
Computational study of the pho ...
Homo sapiens
Chemistry
13
8437-8444
2007
-
-
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1
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1
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692997
North
Mitotic regulation of SIRT2 by ...
Homo sapiens
J. Biol. Chem.
282
19546-19555
2007
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2
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4
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4
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1
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693022
Taniguchi
Phosphorylation of adult type ...
Mus musculus
J. Biol. Chem.
282
7869-7876
2007
1
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3
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1
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2
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-
-
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693721
Saito
p25/cyclin-dependent kinase 5 ...
Rattus norvegicus
J. Neurochem.
102
133-140
2007
1
1
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1
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2
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1
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1
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2
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1
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2
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1
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1
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1
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2
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1
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693746
Anne
Phosphorylation of huntingtin ...
Mus musculus, Rattus norvegicus
J. Neurosci.
27
7318-7328
2007
2
-
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2
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2
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2
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2
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2
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4
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2
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2
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2
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2
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2
-
-
2
-
-
-
-
-
-
-
-
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-
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693903
Sanchez
Nuclear export of the human cy ...
Homo sapiens
J. Virol.
81
11730-11736
2007
-
-
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1
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7
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3
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1
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1
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1
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1
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1
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3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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694216
Huang
Pho85, a multifunctional cycli ...
Saccharomyces cerevisiae
Mol. Microbiol.
66
303-314
2007
-
-
-
-
-
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1
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6
-
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9
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2
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12
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12
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1
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9
-
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-
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-
694510
Marchetti
Structure-based design of 2-ar ...
Homo sapiens
Org. Biomol. Chem.
5
1577-1585
2007
-
-
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-
-
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29
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1
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1
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2
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1
3
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24
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1
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24
29
3
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1
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-
-
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-
-
694625
Cui
Roles of Arabidopsis cyclin-de ...
Arabidopsis thaliana
Plant Cell
19
1388-1402
2007
-
-
2
-
2
-
-
-
-
-
-
-
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10
-
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2
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4
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2
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2
2
-
2
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-
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678181
Li
Cyclin-dependent protein kinas ...
Bos taurus, Homo sapiens, Rattus norvegicus
Biochemistry
45
3134-3145
2006
2
-
1
-
-
-
1
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1
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2
1
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5
-
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-
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2
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4
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6
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2
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1
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1
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1
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2
1
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2
-
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4
-
-
-
-
-
-
-
-
-
-
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-
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679021
Yang
Phosphorylation of ezrin by cy ...
Homo sapiens
Cancer Res.
66
2708-2715
2006
-
1
-
-
-
-
1
-
-
-
-
-
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3
-
-
-
-
-
1
-
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1
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2
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-
-
-
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-
-
1
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-
-
-
-
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1
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-
-
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-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679024
den Hollander
Dynein light chain 1 contribut ...
Homo sapiens
Cancer Res.
66
5941-5949
2006
1
1
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-
-
-
-
-
-
-
-
-
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2
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-
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-
3
-
-
1
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2
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-
-
-
-
-
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-
1
1
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-
-
-
-
-
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-
-
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-
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-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679026
Strock
Cyclin-dependent kinase 5 acti ...
Homo sapiens
Cancer Res.
66
7509-7515
2006
1
1
1
-
1
-
2
-
-
-
-
-
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3
-
-
-
-
-
4
-
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1
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2
-
-
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-
1
1
1
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-
1
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2
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-
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-
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4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679092
Bayart
The Bloom syndrome helicase is ...
Homo sapiens
Cell Cycle
5
1681-1686
2006
-
-
-
-
-
-
1
-
-
-
-
1
-
3
-
-
-
-
-
2
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3
-
1
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-
-
-
-
-
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-
-
-
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-
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1
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-
1
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2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679093
Wohlbold
The cyclin-dependent kinase (C ...
Mus musculus
Cell Cycle
5
546-554
2006
1
1
1
-
-
-
1
-
-
-
1
-
-
7
-
-
1
-
-
12
-
-
1
-
5
-
-
-
-
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
12
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679842
Sengupta
Regulation of phosphorylation ...
Homo sapiens
FEBS Lett.
580
5925-5933
2006
-
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679989
Enders
Traffic safety for the cell: i ...
Saccharomyces cerevisiae, Homo sapiens
Gene
371
1-6
2006
4
1
-
-
2
-
5
-
-
-
-
1
-
2
-
-
-
-
-
3
-
-
13
-
5
-
-
-
-
-
-
-
-
-
-
-
4
1
-
-
-
2
-
-
5
-
-
-
-
-
1
-
-
-
-
-
3
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681676
Sanchez
Cyclin-dependent kinase activi ...
Homo sapiens
J. Virol.
80
5886-5896
2006
-
1
-
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681816
Chen
Identification of an effector ...
Plasmodium falciparum
Mol. Biochem. Parasitol.
149
48-57
2006
2
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
682537
Pareek
Cyclin-dependent kinase 5 acti ...
Mus musculus, Rattus norvegicus
Proc. Natl. Acad. Sci. USA
103
791-796
2006
4
2
-
-
-
-
2
-
-
-
-
-
-
3
-
-
-
-
-
8
-
-
3
-
4
-
-
-
-
-
-
-
-
-
-
-
4
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
8
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
662686
Darios
Neurotoxic calcium transfer fr ...
Rattus norvegicus
J. Neurosci.
25
4159-4168
2005
1
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1
-
-
-
1
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3
1
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2
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2
-
-
-
-
-
2
-
-
4
-
3
1
-
-
-
1
-
-
1
-
-
-
1
-
1
1
-
-
-
-
1
-
-
3
1
-
2
-
-
-
-
-
2
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
662855
Lambourne
Increased tau phosphorylation ...
Homo sapiens, Mus musculus
Mol. Cell. Biol.
25
278-293
2005
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1
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6
2
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4
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5
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2
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7
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2
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1
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6
2
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2
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7
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664955
Zong
Cyclin-dependent kinase 11(p58 ...
Homo sapiens
FEBS Lett.
579
3579-3588
2005
1
-
1
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1
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1
1
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3
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2
1
2
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1
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1
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1
1
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1
1
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1
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2
1
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665645
Habran
Varicella-Zoster Virus IE63 Pr ...
Chlorocebus aethiops
J. Biol. Chem.
280
29135-29143
2005
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-
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2
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1
1
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1
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2
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1
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5
1
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1
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1
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1
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2
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1
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1
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1
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3
-
1
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-
1
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665977
VanderWel
Pyrido[2,3-d]pyrimidin-7-ones ...
Homo sapiens
J. Med. Chem.
48
2371-2387
2005
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-
-
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38
-
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1
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3
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2
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4
1
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1
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4
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4
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38
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1
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2
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1
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1
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665980
Brana
Pyrazolo[3,4-c]pyridazines as ...
Marthasterias glacialis, Homo sapiens
J. Med. Chem.
48
6843-6854
2005
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-
1
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48
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2
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2
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1
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1
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2
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2
2
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4
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4
1
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48
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2
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1
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1
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2
-
2
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2
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665982
Lu
Crystal structure of a human c ...
Homo sapiens
J. Med. Chem.
48
737-743
2005
1
1
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1
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8
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1
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1
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3
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2
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4
1
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1
1
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3
1
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8
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1
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1
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2
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1
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1
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-
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666109
Van Dross
Constitutively active K-cyclin ...
Homo sapiens
J. Natl. Cancer Inst.
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656-666
2005
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-
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1
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2
1
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2
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4
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1
1
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3
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5
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3
1
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1
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7
-
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7
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1
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2
1
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2
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1
1
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3
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5
-
1
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-
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1
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-
-
-
-
-
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666117
Wei
Control of cyclin-dependent ki ...
Mus musculus, Mus musculus ICR
J. Neurochem.
93
502-512
2005
3
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1
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3
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1
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9
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2
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4
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2
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2
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1
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1
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4
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2
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666120
Zhu
Activation of latent cyclin-de ...
Rattus norvegicus
J. Neurochem.
94
1535-1545
2005
5
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2
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1
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3
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1
1
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2
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3
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2
1
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1
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1
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5
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1
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2
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1
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1
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1
1
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2
-
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3
-
1
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-
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1
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-
-
-
-
-
-
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-
666347
Narayanan
Cyclin-dependent kinase activi ...
Homo sapiens
Mol. Cell. Biol.
25
264-277
2005
-
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1
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1
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2
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1
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1
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1
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4
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2
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2
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1
2
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1
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1
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4
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666440
Loog
Cyclin specificity in the phos ...
Saccharomyces cerevisiae
Nature
434
104-108
2005
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1
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4
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1
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1
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2
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1
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5
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1
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3
1
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4
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4
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1
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4
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1
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1
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1
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5
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3
1
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666466
Hahn
Role of cyclin-dependent kinas ...
Gallus gallus
Neuroscience
134
449-465
2005
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1
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3
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2
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2
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4
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3
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2
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1
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1
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4
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3
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666588
Gutierrez
Maize cyclin D2 expression, as ...
Zea mays
Plant Cell Physiol.
46
166-173
2005
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-
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-
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1
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3
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1
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1
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5
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3
1
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1
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2
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2
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1
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3
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1
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5
-
1
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1
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666635
Corellou
Atypical regulation of a green ...
Ostreococcus tauri
Plant Physiol.
138
1627-1636
2005
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-
1
-
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1
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1
1
1
1
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8
-
1
1
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1
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3
1
3
1
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-
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-
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3
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1
3
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1
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1
1
1
1
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1
1
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1
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3
1
1
-
-
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-
-
-
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-
-
-
-
666728
Watanabe
Cyclin-dependent kinase (CDK) ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
102
11663-11668
2005
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-
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1
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1
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2
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1
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1
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3
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1
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2
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2
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1
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1
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2
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1
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3
-
-
-
-
-
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-
-
-
-
-
-
-
-
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666744
Lim
Cyclin-dependent kinase 6 asso ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
102
5156-5161
2005
-
-
1
-
-
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2
-
2
1
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1
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2
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1
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1
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2
-
-
-
-
-
-
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2
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-
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1
2
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-
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2
-
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2
1
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1
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666862
Bartova
The mechanism of inhibition of ...
Homo sapiens
Protein Sci.
14
445-451
2005
-
-
-
1
-
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1
-
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1
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1
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1
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-
-
-
-
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2
1
2
-
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-
-
-
-
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2
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-
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2
1
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1
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1
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1
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-
-
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2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
662688
Shelton
Effects of cyclin-dependent ki ...
Mus musculus
J. Neurosci. Res.
76
110-120
2004
4
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1
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1
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1
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4
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-
-
-
11
-
-
5
-
5
1
-
-
-
1
-
-
1
-
-
-
4
-
1
1
-
-
-
-
1
-
-
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1
-
2
-
-
-
-
-
11
-
-
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
663933
Bukczynska
The T-cell protein tyrosine ph ...
Homo sapiens
Biochem. J.
380
939-949
2004
1
-
-
-
-
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3
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1
-
1
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3
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-
-
-
-
1
-
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3
-
1
1
-
-
-
1
-
-
2
-
-
-
1
-
-
2
-
-
-
-
3
-
-
-
1
-
1
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-
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-
-
1
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
664030
Li
The nuclear protein p34SEI-1 r ...
Homo sapiens
Biochemistry
43
4394-4399
2004
1
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
2
-
2
1
-
-
-
1
-
-
2
-
-
-
1
-
-
2
-
-
-
-
-
-
-
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1
-
1
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-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
664179
Kesavapany
Neuronal cyclin-dependent kina ...
Danio rerio, Saccharomyces cerevisiae, Caenorhabditis elegans, Canis lupus familiaris, Drosophila melanogaster, Homo sapiens, Doryteuthis pealeii, Mus musculus, Rattus norvegicus, Sus scrofa
Biochim. Biophys. Acta
1697
143-153
2004
13
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10
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1
-
11
-
13
1
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46
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10
-
1
-
-
-
25
-
-
81
-
10
-
-
-
-
-
-
-
10
-
-
-
13
-
10
10
-
1
-
-
11
-
-
13
1
-
46
-
-
1
-
-
25
-
-
81
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664332
Yang
Multisite phosphorylation and ...
eukaryota
Biophys. J.
86
3432-3443
2004
1
-
-
-
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1
1
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-
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1
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1
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1
-
-
-
-
-
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1
-
1
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-
-
-
-
-
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2
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1
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2
-
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-
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1
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1
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1
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1
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-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664536
Andres
Control of vascular cell proli ...
Homo sapiens, Mus musculus, Rattus norvegicus
Cardiovasc. Res.
63
11-21
2004
3
1
-
-
1
-
29
-
-
-
-
12
-
3
-
3
-
-
-
7
-
-
21
-
3
-
-
-
-
-
-
-
6
-
-
8
3
1
-
6
-
1
-
8
29
-
-
-
-
-
12
-
-
3
-
-
7
-
-
21
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
665497
Harwell
Activation of cyclin-dependent ...
Homo sapiens
J. Biol. Chem.
279
12695-12705
2004
1
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1
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1
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-
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1
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1
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1
-
1
-
-
-
1
-
-
2
-
2
1
-
-
-
1
-
-
3
-
-
-
1
-
1
3
-
1
-
-
-
-
-
-
1
-
1
-
-
1
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
666186
Sanchez
Cyclin-dependent kinase activi ...
Homo sapiens
J. Virol.
78
11219-11232
2004
-
-
-
-
-
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3
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-
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1
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3
-
-
-
-
-
3
-
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1
-
1
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-
-
-
-
-
-
1
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-
-
-
-
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1
-
-
-
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3
-
-
-
-
-
1
-
-
-
-
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3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666340
Pic-Taylor
Regulation of cell cycle-speci ...
Saccharomyces cerevisiae
Mol. Cell. Biol.
24
10036-10046
2004
3
-
-
-
-
-
-
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1
-
-
1
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3
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1
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-
-
-
-
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2
1
2
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1
-
-
-
-
-
1
-
-
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3
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
666401
Zhen
Regulation of cyclin-dependent ...
Rattus norvegicus
Mol. Pharmacol.
66
1500-1507
2004
3
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-
-
-
-
2
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1
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3
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5
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-
-
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2
1
-
3
-
2
1
-
-
-
1
-
-
1
-
-
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3
-
-
1
-
-
-
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2
-
-
-
1
-
3
-
-
-
-
-
2
1
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
666468
Gompel
Expression and activity of cyc ...
Homo sapiens
Neurosignals
13
134-143
2004
1
-
-
-
-
-
3
-
-
1
-
1
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1
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-
1
-
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3
-
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2
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3
1
-
-
-
1
-
-
2
-
-
-
1
-
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2
-
-
-
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3
-
-
-
1
-
1
-
-
-
1
-
3
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
666574
Boudolf
The plant-specific cyclin-depe ...
Arabidopsis thaliana
Plant Cell
16
2683-2692
2004
-
-
1
-
1
-
-
-
-
-
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1
-
4
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
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-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666575
Shimotohno
The plant-specific kinase CDKF ...
Arabidopsis thaliana
Plant Cell
16
2954-2966
2004
1
-
1
-
1
-
-
-
1
-
1
1
-
5
-
1
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
2
-
-
-
1
-
1
2
-
1
-
-
-
-
-
1
-
1
1
-
-
1
-
-
1
-
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1
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Activation loop phosphorylatio ...
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The specificities of protein k ...
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Mitotic-like tau phosphorylati ...
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664005
Li
An NF-kappaB-specific inhibito ...
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2
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1
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1
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664160
Sachs
Cyclin-dependent kinase 11p110 ...
Homo sapiens
Biochim. Biophys. Acta
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2003
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1
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1
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3
1
1
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1
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664689
Furet
X-ray crystallographic studies ...
Homo sapiens
Curr. Med. Chem. Anticancer Agents
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15-23
2003
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28
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665053
D'Angiolella
The spindle checkpoint require ...
Homo sapiens, Xenopus laevis
Genes Dev.
17
2520-2525
2003
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2
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The PHOA and PHOB cyclin-depen ...
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665488
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8
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Vax
Activating point mutations in ...
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3
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Freeman
Isolation, characterization an ...
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Woodard
Oxindole-based compounds are s ...
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Rideout
Cyclin-dependent kinase activi ...
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2003
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Davido
The differential requirement f ...
Homo sapiens
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666185
Sanchez
Mechanisms governing maintenan ...
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1
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666467
Hisanaga
The regulation of cyclin-depen ...
Homo sapiens, Mus musculus, Rattus norvegicus
Neurosignals
12
221-229
2003
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3
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666705
Yamaguchi
Control of in vitro organogene ...
Oryza sativa
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491211
Wood
The genome sequence of Schizos ...
Schizosaccharomyces pombe
Nature
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871-880
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491460
MacCoss
Shotgun identification of prot ...
Schizosaccharomyces pombe
Proc. Natl. Acad. Sci. USA
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7900-7905
2002
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Adams
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491457
Ellenrieder
The long form of CDK2 arises v ...
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DNA Cell Biol.
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413-423
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491590
Hadano
A gene encoding a putative GTP ...
Homo sapiens
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166-173
2001
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490160
Adams
The genome sequence of Drosoph ...
Drosophila melanogaster
Science
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491451
Tanaka
A pcl-like cyclin activates th ...
Schizosaccharomyces pombe
Mol. Biol. Cell
11
2845-2862
2000
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491461
Machida
A 38 kb segment containing the ...
Schizosaccharomyces pombe
Yeast
16
71-80
2000
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491466
Korsisaari
Interactions of Cdk7 and Kin28 ...
Saccharomyces cerevisiae
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491557
Liu
Genomic organization and chara ...
Homo sapiens
Gene
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1
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Sequence and analysis of chrom ...
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Analysis of yeast protein kina ...
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Sequence and analysis of chrom ...
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The PISSLRE gene: structure, e ...
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Identification and characteriz ...
Homo sapiens
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Characterization of the Prk1 p ...
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Yeast
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T-loop deletion of CDC2 from b ...
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Prevalence of p16 and CDK4 ger ...
Homo sapiens
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Exploiting chemical libraries, ...
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Akoulitchev
The molecular mechanism of mit ...
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Structural basis for inhibitio ...
Homo sapiens
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Prediction of the coding seque ...
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DNA Res.
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Transcript mapping in a 46-kb ...
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Genomics
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Protein kinase inhibition by s ...
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The nucleotide sequence of Sac ...
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103-105
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Active and inactive protein ki ...
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The sequence of a 20.3 kb DNA ...
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Yeast
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Novel members of the cdc2-rela ...
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Germline mutations in the p16I ...
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High-resolution crystal struct ...
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Russo
Crystal structure of the p27Ki ...
Homo sapiens
Nature
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De Azevedo
Structural basis for specifici ...
Homo sapiens
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Crystal structure and mutation ...
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Damagnez
Candida albicans CDK1 and CYB1 ...
Candida albicans
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Fobert
Distinct classes of cdc2-relat ...
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Plant Cell
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532803
Kaldis
The Cdk-activating kinase (CAK ...
Saccharomyces cerevisiae
Cell
86
553-564
1996
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1
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1
1
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490796
Hunter
Protein kinases and phosphatas ...
eukaryota
Cell
80
225-236
1995
2
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1
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2
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4
2
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491458
Baur
Sequence analysis of a 5.6 kb ...
Saccharomyces cerevisiae
Yeast
11
455-458
1995
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2
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5
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491479
Wolfel
A p16INK4a-insensitive CDK4 mu ...
Homo sapiens
Science
269
1281-1284
1995
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1
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491515
Jeffrey
Mechanism of CDK activation re ...
Homo sapiens
Nature
376
313-320
1995
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491525
Rasmussen
A 37.5 kb region of yeast chro ...
Saccharomyces cerevisiae
Yeast
11
873-883
1995
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1
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491534
Mottram
A family of trypanosome cdc2-r ...
Trypanosoma brucei brucei
Gene
162
147-152
1995
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3
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3
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7
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2
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3
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491538
Navarro-Garcia
Functional characterization of ...
Candida albicans
Mol. Cell. Biol.
15
2197-2206
1995
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1
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491547
Tassan
Identification of human cyclin ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
92
8871-8875
1995
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4
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1
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491548
Ohshima
Molecular cloning and chromoso ...
Mus musculus
Genomics
28
585-588
1995
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1
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1
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1
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2
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491559
Best
Cloning of a full-length cDNA ...
Homo sapiens
Biochem. Biophys. Res. Commun.
208
562-568
1995
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1
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1
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491561
Gervasi
The Xenopus laevis homologue t ...
Xenopus laevis
Brain Res. Mol. Brain Res.
33
192-200
1995
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7
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3
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491564
Michaelis
A Dictyostelium discoideum gen ...
Dictyostelium discoideum
Biochem. Cell Biol.
73
51-58
1995
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7
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1
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491588
Kotani
A variant form of cyclin-depen ...
Rattus norvegicus
Oncogene
10
663-669
1995
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-
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5
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491589
Hosokawa
Synergistic gene expressions o ...
Rattus norvegicus
Biochem. Mol. Biol. Int.
37
393-399
1995
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1
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532685
Murakami
Analysis of the nucleotide seq ...
Saccharomyces cerevisiae
Nat. Genet.
10
261-268
1995
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532808
Pu
Mitotic destruction of the cel ...
Aspergillus nidulans
EMBO J.
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995-1003
1995
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1
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2
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1
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2
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Pu
Isolation of a functional homo ...
Aspergillus nidulans, Neurospora crassa
J. Biol. Chem.
270
18110-18116
1995
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1
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489976
MacKintosh
Inhibitors of protein kinases ...
eukaryota
Trends Biochem. Sci.
19
444-448
1994
1
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3
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1
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Kemp
Substrate and pseudosubstrate ...
Mammalia
Trends Biochem. Sci.
19
440-444
1994
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1
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2
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491369
Wilson
2.2 Mb of contiguous nucleotid ...
Caenorhabditis elegans
Nature
368
32-38
1994
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491449
Roemer
DNA sequence analysis of a 10. ...
Saccharomyces cerevisiae
Yeast
10
1527-1530
1994
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1
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491485
Kaffman
Phosphorylation of the transcr ...
Saccharomyces cerevisiae
Science
263
1153-1156
1994
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1
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491489
Labbe
p40MO15 associates with a p36 ...
Xenopus laevis
EMBO J.
13
5155-5164
1994
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1
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491522
Kato
Regulation of cyclin D-depende ...
Mus musculus
Mol. Cell. Biol.
14
2713-2721
1994
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1
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1
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491531
Mori
The identification of a Caenor ...
Caenorhabditis elegans
Mol. Gen. Genet.
245
781-786
1994
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1
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491537
Sherlock
Molecular cloning and analysis ...
Candida albicans
Mol. Gen. Genet.
245
716-723
1994
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1
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491542
Kerr
Characterization of the synthe ...
Rattus norvegicus
Biochim. Biophys. Acta
1218
375-387
1994
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491544
Hellmich
Cloning and characterization o ...
Drosophila melanogaster
FEBS Lett.
356
317-321
1994
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1
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491545
Yang
Identification of cDNAs encodi ...
Bos taurus
Gene
141
283-286
1994
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1
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1
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1
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-
1
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-
-
-
491549
Ino
Expression of CDK5 (PSSALRE ki ...
Mus musculus
Brain Res.
661
196-206
1994
-
-
-
-
-
-
-
-
-
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1
-
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-
-
13
-
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1
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13
-
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-
-
491552
Wu
Molecular cloning of the human ...
Homo sapiens
Oncogene
9
2089-2096
1994
-
-
1
-
-
-
-
-
-
-
-
-
-
1
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1
-
1
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1
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-
1
-
-
-
-
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-
491553
Tassan
Cell cycle analysis of the act ...
Homo sapiens
J. Cell. Biol.
127
467-478
1994
-
-
1
-
-
-
-
-
-
-
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8
-
-
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-
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-
2
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
491554
Levedakou
Two novel human serine/threoni ...
Homo sapiens
Oncogene
9
1977-1988
1994
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
3
-
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-
-
1
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-
-
1
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-
3
-
-
-
-
-
-
-
-
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-
-
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-
-
-
-
491555
Fisher
A novel cyclin associates with ...
Homo sapiens
Cell
78
713-724
1994
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
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2
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2
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-
491556
Darbon
Cloning, expression and subcel ...
Homo sapiens
Oncogene
9
3127-3138
1994
-
-
1
-
-
-
-
-
-
-
-
-
-
9
-
-
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-
-
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-
1
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1
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-
-
491560
Grana
PITALRE, a nuclear CDC2-relate ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
91
3834-3838
1994
-
-
1
-
-
-
-
-
1
-
1
-
-
4
-
-
-
-
-
-
-
-
-
1
1
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-
1
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-
-
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1
-
1
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-
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491562
Di Lallo
The Histoplasma capsulatum cdc ...
Histoplasma capsulatum
Gene
140
51-57
1994
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
1
-
-
-
-
1
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-
-
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-
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491567
Osmani
-
A single p34cdc2 protein kinas ...
Aspergillus nidulans
J. Cell Sci.
107
1519-1528
1994
-
-
1
-
-
-
-
-
-
-
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1
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2
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-
1
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-
-
-
-
-
-
-
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-
-
-
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-
-
-
-
491572
Stepanova
Sequence of the cDNA encoding ...
Mus musculus
Gene
149
321-324
1994
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
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-
-
2
-
-
-
-
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-
-
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1
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
491573
Matsuoka
Activation of cyclin-dependent ...
Mus musculus
Mol. Cell. Biol.
14
7265-7275
1994
1
-
-
-
-
-
-
-
-
-
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3
-
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-
-
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1
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1
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-
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-
-
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-
-
-
-
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-
-
-
-
491582
Ross-Macdonald
Isolation and expression of a ...
Plasmodium falciparum
Eur. J. Biochem.
220
693-701
1994
-
-
1
-
-
-
-
-
3
-
-
-
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7
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
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-
1
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-
-
-
-
-
-
-
3
-
-
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-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491584
Grana
PISSLRE, a human novel CDC2-re ...
Homo sapiens
Oncogene
9
2097-2103
1994
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
2
-
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-
-
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-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491585
Brambilla
Molecular cloning of PISSLRE, ...
Homo sapiens
Oncogene
9
3037-3041
1994
-
-
1
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
4
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
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-
1
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-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491462
MacNeill
Mutational analysis of the fis ...
Schizosaccharomyces pombe
Mol. Gen. Genet.
236
415-426
1993
-
-
-
-
1
-
-
-
-
-
-
1
-
7
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
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-
-
1
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1
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491468
Valay
The kin28 protein kinase is as ...
Saccharomyces cerevisiae
J. Mol. Biol.
234
307-310
1993
-
-
-
-
-
-
-
-
-
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1
-
1
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-
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1
-
1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491480
Khatib
Coamplification of the CDK4 ge ...
Homo sapiens
Cancer Res.
53
5535-5541
1993
-
-
-
-
-
-
-
-
-
-
1
1
-
3
-
-
-
-
-
1
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491494
Poon
The cdc2-related protein p40MO ...
Xenopus laevis
EMBO J.
12
3123-3132
1993
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491496
Stern
Genetic analysis of the Drosop ...
Xenopus laevis
Development
117
219-232
1993
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491497
Clegg
A developmental and molecular ...
Xenopus laevis
Genome
36
676-685
1993
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
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-
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-
1
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491501
Fesquet
The MO15 gene encodes the cata ...
Xenopus laevis
EMBO J.
12
3111-3121
1993
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
1
-
-
4
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491516
De Bondt
Crystal structure of cyclin-de ...
Homo sapiens
Nature
363
595-602
1993
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491521
Ershler
Novel CDC2-related protein kin ...
Mus musculus
Gene
124
305-306
1993
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
3
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491528
Michaelis
The isolation from a unicellul ...
Dictyostelium discoideum
Biochim. Biophys. Acta
1179
117-124
1993
-
-
-
-
-
-
-
-
-
-
-
1
-
6
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491532
Cho
Cloning of the rat cyclin-depe ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
191
860-865
1993
-
-
1
-
-
-
-
-
-
-
-
-
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4
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
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-
-
1
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-
-
-
-
-
-
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491533
Molz
Characterization of the fissio ...
Schizosaccharomyces pombe
EMBO J.
12
1723-1732
1993
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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-
-
-
-
-
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-
1
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-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491540
Moran
Molecular cloning of two novel ...
Arabidopsis thaliana
Biochim. Biophys. Acta
1216
9-14
1993
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491546
Noguchi
Molecular cloning and identifi ...
Mesocricetus auratus
Biochem. Biophys. Res. Commun.
197
1524-1529
1993
-
-
1
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
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-
-
1
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-
-
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491578
Lohia
Cloning of the Eh cdc2 gene fr ...
Entamoeba histolytica
Gene
127
203-207
1993
-
-
1
-
-
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
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-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491579
Bladt
Characterization and expressio ...
Mus musculus
Differentiation
53
115-122
1993
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
1
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-
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-
-
-
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1
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-
491580
Hirt
cdc2MsB, a cognate cdc2 gene f ...
Medicago sativa
Plant J.
4
61-69
1993
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1
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12
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1
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2
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1
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1
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491581
Mottram
A novel CDC2-related protein k ...
Leishmania mexicana
J. Biol. Chem.
268
21044-21052
1993
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10
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1
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491587
Hong
p34cdc2 protein kinase homolog ...
Vigna aconitifolia
Plant Physiol.
101
1399-1400
1993
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1
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490424
Gilardi-Hebenstreit
An Eph-related receptor protei ...
Mus musculus
Oncogene
7
2499-2506
1992
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1
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4
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2
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2
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2
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1
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2
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-
2
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491445
Biggs
Primary structure, expression, ...
Drosophila melanogaster
Proc. Natl. Acad. Sci. USA
89
6295-6299
1992
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2
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1
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491491
Eipers
Structure and expression of th ...
Homo sapiens
Genomics
13
613-621
1992
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1
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4
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2
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491502
Pickham
Requirement of mosXe protein k ...
Xenopus laevis
Mol. Cell. Biol.
12
3192-3203
1992
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14
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6
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2
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14
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491503
Inze
Control of cell division in pl ...
Arabidopsis thaliana
Biochem. Soc. Trans.
20
80-84
1992
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1
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1
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491504
Imajuku
Exon-intron organization of th ...
Arabidopsis thaliana
FEBS Lett.
304
73-77
1992
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7
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3
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491517
Gu
Cell cycle regulation of CDK2 ...
Homo sapiens
EMBO J.
11
3995-4005
1992
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1
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3
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1
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1
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1
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1
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491523
Matsushime
Identification and properties ...
Mus musculus
Cell
71
323-334
1992
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3
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1
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491527
Michaelis
Isolation and characterization ...
Dictyostelium discoideum
Biochim. Biophys. Acta
1132
35-42
1992
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5
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1
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491541
Hirai
Isolation and characterization ...
Carassius auratus
Dev. Biol.
152
113-120
1992
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1
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1
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2
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1
1
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1
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2
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1
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491565
Meyerson
A family of human cdc2-related ...
Homo sapiens
EMBO J.
11
2909-2917
1992
-
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11
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7
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491568
Brown
The Crithidia fasciculata CRK ...
Crithidia fasciculata
Nucleic Acids Res.
20
5451-5456
1992
-
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1
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5
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1
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1
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1
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1
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