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Literature summary for 2.7.11.22 extracted from
- Mitotic-like tau phosphorylation by p25-Cdk5 kinase complex (2003), J. Biol. Chem., 278, 34026-34034.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| p25 | inducible cytotoxic expression factor required for Cdk5 activity, formation of a complex with Cdk5, p25 overexpression increases tau phosphorylation rate | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| LiCl | slight inhibition of T231 phosphorylation by p25-Cdk5 kinase complex | Homo sapiens |  |
| additional information | no inhibition of the p25-Cdk5 kinase complex by PD98059 and SB203580 | Homo sapiens | |
| roscovitine | complete inhibition of T231 phosphorylation by 25-Cdk5 kinase complex | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| microtubule | - |
Homo sapiens | 5874 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [tau-protein] | Homo sapiens | cdk5 associated with p25, cdk5 substrate in brain | ADP + O-phospho-[tau-protein] | - |
? | |
| additional information | Homo sapiens | abnormal phosphorylation of tau in dividing cells leads to its accumulation in the cytosol as microtubule-free form, Cdk5 is involved in neurodegenerative mechanisms | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neuroblastoma cell | - |
Homo sapiens | - |
| neuron | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [tau-protein] | cdk5 associated with p25, cdk5 substrate in brain | Homo sapiens | ADP + O-phospho-[tau-protein] | - |
? | |
| ATP + [tau-protein] | cdk5 associated with p25, recombinant bacterially expressed human tau protein as substrate, phosphorylation of the AT8 and AT180 epitopes, and at T231 of the Alzheimer's mitotic epitope TG-3 | Homo sapiens | ADP + O-phospho-[tau-protein] | - |
? | |
| additional information | abnormal phosphorylation of tau in dividing cells leads to its accumulation in the cytosol as microtubule-free form, Cdk5 is involved in neurodegenerative mechanisms | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | see also EC 2.7.11.26 | Homo sapiens |
| p25-Cdk5 kinase complex | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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