Activating Compound | Comment | Organism | Structure |
---|---|---|---|
p35 | tightly bound neuronal activators of cdk5, required for activity with regulatory function, p39 activates to a greater extent compared to p35 in vitro | Mus musculus | |
p39 | tightly bound neuronal activators of cdk5, required for activity with regulatory function, p39 activates to a greater extent compared to p35 in vitro, p39 is the activator activator in vivo | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a cdk-deficient mouse mutant lacks tau phosphorylation activity | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | Mus musculus | cdk5 substrate in brain, cdk5 associated with p39, tau is a microtubule-associated and developmentally regulated protein involved in axonal development in neurons, tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules, reaction of EC 2.7.11.26 | ADP + O-phospho -[tau-protein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | developing postnatal and embryonic | Mus musculus | - |
brain stem | - |
Mus musculus | - |
cerebellum | - |
Mus musculus | - |
cerebral cortex | - |
Mus musculus | - |
additional information | expression pattern during brain development | Mus musculus | - |
spinal cord | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone H1 | preferred substrate of cdk5 associated with p35 | Mus musculus | ADP + phosphorylated histone H1 | - |
? | |
ATP + [tau-protein] | cdk5 substrate in brain, cdk5 associated with p39, tau is a microtubule-associated and developmentally regulated protein involved in axonal development in neurons, tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules, reaction of EC 2.7.11.26 | Mus musculus | ADP + O-phospho -[tau-protein] | - |
? | |
ATP + [tau-protein] | preferred substrate of cdk5 associated with p39, recombinant bacterially expressed human tau protein as substrate, phosphorylation at Ser202 and Thr205, reaction of EC 2.7.11.26 | Mus musculus | ADP + O-phospho -[tau-protein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cdk5 | - |
Mus musculus |
cyclin-dependent kinase 5/p39 | - |
Mus musculus |
More | see also EC 2.7.11.26 | Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |