Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.22 extracted from

  • Adams, J.A.
    Kinetic and catalytic mechanisms of protein kinases (2001), Chem. Rev., 101, 2271-2290.
    View publication on PubMed
Search for more literature for 2.7.11.22

Activating Compound

Activating Compound Comment Organism Structure
cyclin A cdk2 is dependent on, required as activating subunit, complexes with cdk2 eukaryota

Crystallization (Commentary)

Crystallization (Comment) Organism
cdk2, X-ray diffraction structure analysis eukaryota

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ can partially substitue Mg2+ eukaryota
Co2+ can partially substitue Mg2+ eukaryota
Mg2+ dependent on, Mg2+ is the physiologic metal ion, other divalent cations are able to support nucleotide binding, but only Mn2+, Co2+, and Cd2+ can substitute Mg2+ in supporting the catalytic activity eukaryota
Mn2+ can partially substitue Mg2+ eukaryota

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein eukaryota
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
eukaryota
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein regulation by phosphorylation of the activation loop, does not affect ATP binding, but enhances the phosphotransfer rate and the substrate binding eukaryota

Reaction

Reaction Comment Organism Reaction ID
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate reaction mechanism eukaryota
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 eukaryota ADP + a phosphoprotein
-
 ?
ATP + a protein cdk2-cyclin A phosphorylates e.g. protein substrate p107 and peptide substrate PKTPKKAKKL, requiring a small hydrophobic patch RXL, known as a recruitment peptide eukaryota ADP + a phosphoprotein
-
 ?
additional information poor activity on free amino acids, consensus sequence of cdk2 is S/TP-XR/K eukaryota ?
-
 ?

Subunits

Subunits Comment Organism
More the enzyme requires a cyclin as activating subunit eukaryota

Synonyms

Synonyms Comment Organism
CDK2
-
 eukaryota
cyclin-dependent kinase-2
-
 eukaryota

Cofactor

Cofactor Comment Organism Structure
ATP dependent on eukaryota