Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.21 extracted from

  • Ritter, A.; Friemel, A.; Kreis, N.N.; Louwen, F.; Yuan, J.
    Impact of Polo-like kinase 1 inhibitors on human adipose tissue-derived mesenchymal stem cells (2016), Oncotarget, 6, 6641-6655.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.21

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + mitotic centromere-associated kinesin Homo sapiens i.e. MCAK, residue S621 in MCAK is the major phosphorylation site of Plk1, residues S632/S633 are also phoshorylated by Plk1. S632/S633 phosphorylation significantly enhances the microtubule depolymerizing activity of MCAK in vivo and in vitro ADP + phosphorylated mitotic centromere-associated kinesin
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NYY3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + mitotic centromere-associated kinesin i.e. MCAK, residue S621 in MCAK is the major phosphorylation site of Plk1, residues S632/S633 are also phoshorylated by Plk1. S632/S633 phosphorylation significantly enhances the microtubule depolymerizing activity of MCAK in vivo and in vitro Homo sapiens ADP + phosphorylated mitotic centromere-associated kinesin
-
 ?
ATP + mitotic centromere-associated kinesin i.e. MCAK, residue S621 in MCAK is the major phosphorylation site of Plk1, residues S632/S633 are also phoshorylated by Plk1 Homo sapiens ADP + phosphorylated mitotic centromere-associated kinesin
-
 ?

Synonyms

Synonyms Comment Organism
Plk1
-
 Homo sapiens
Polo-like kinase 1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the mitotic centromere-associated kinesin (MCAK), a potent microtubule depolymerase, is involved in regulating microtubule dynamics. The activity and subcellular localization of MCAK are tightly regulated by key mitotic kinases, such as Polo-like kinase 1 (Plk1) by phosphorylating multiple residues in MCAK. Plk1 phosphorylates very often different residues of substrates at different stages. Residue S621 in MCAK is the major phosphorylation site of Plk1, which is responsible for regulating MCAK's degradation by promoting the association of MCAK with APC/C_Cdc20. Plk1 also phosphorylates S632/S633 and regulates its catalytic activity in mitosis, this phosphorylation is required for proper spindle assembly during early phases of mitosis Homo sapiens