Literature summary for 2.7.11.21 extracted from

Rodriguez-Rodriguez, J.A.; Moyano, Y.; Jativa, S.; Queralt, E.
Mitotic exit function of polo-like kinase Cdc5 is dependent on sequential activation by Cdk1 (2016), Cell Rep., 15, 2050-2062.

Search for more literature for 2.7.11.21

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	Cdc5 is activated by Cdk1 phosphorylation	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
N209A	site-directed mutagenesis, inactive mutant	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Saccharomyces cerevisiae	5634	-

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P32562	strains Y557, Y558, Y918, and Y1031	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	Cdc5 function is regulated by sequential Cdk1 phosphorylation initially mostly at T242 and T238. Initial phosphorylation at T242 activates Cdc5 promotes Cdc14 release , and phosphorylation at T70 contributes to Cdc5-MEN function	Saccharomyces cerevisiae

Synonyms

Synonyms	Comment	Organism
Cdc5	-	Saccharomyces cerevisiae
Cdc5-polo kinase	-	Saccharomyces cerevisiae
polo-like kinase	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
physiological function	Cdc5 contributes to the timely release of Cdc14 in mitosis. Cdc5 acts in parallel with MEN during anaphase. The MEN-independent Cdc5 function requires active separase and activation by Cdk1-dependent phosphorylation. The Cdc5 function is regulated by sequential Cdk1 phosphorylation. Initial phosphorylation at T242 activates Cdc5, which, in turn, promotes Cdc14 release in the metaphase-to-anaphase transition. Cdc14 release on Cdc5 induction does require active Cdc5 kinase activity, and Cdc5-induced Cdc14 release requires Cdc28-Clb2 activity. Phosphorylation at T70 contributes to Cdc5-MEN function in late anaphase. Cdc5 requires separase to induce Cdc14 release from the nucleolus	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)