Literature summary for 2.7.11.21 extracted from

Vazquez-Martin, A.; Oliveras-Ferraros, C.; Cufi, S.; Menendez, J.A.
Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus (2011), Cell Cycle, 10, 1295-1302.

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Inhibitors

Inhibitors	Comment	Organism	Structure
5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide	i.e. GW843682X, inhibition of PLK1 activity abrogates mitotic activation of AMP-activated protein kinasealpha through direct or indirect mechanisms	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
Polo-like kinase 1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the enzyme plays a pivotal role in the regulation of cell cycle progression and the orchestration of cell division	Homo sapiens

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Release 2023.1 (January 2023)