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Literature summary for 2.7.11.21 extracted from

  • Vidanes, G.M.; Sweeney, F.D.; Galicia, S.; Cheung, S.; Doyle, J.P.; Durocher, D.; Toczyski, D.P.
    CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation (2010), PLoS Biol., 8, e1000286.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.21

Cloned(Commentary)

Cloned (Comment) Organism
GAL-HA3-cdc5, GAL-HA3-cdc5-K110A, and GAL-HA3-cdc5-ad are integrated into the plasmids pDM164, pDM173, and pDM191, respectively Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Saccharomyces cerevisiae
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Saccharomyces cerevisiae ADP + a phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
Cdc5
-
 Saccharomyces cerevisiae
polo-like kinase
-
 Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 kinase assay Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function promotes adaptation to the DNA damage checkpoint, in addition to its numerous roles in mitotic progression Saccharomyces cerevisiae