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Literature summary for 2.7.11.21 extracted from
- The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus (2010), Nucleic Acids Res., 38, 2931-2943.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | plk5 is a DNA damage inducible gene | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| into the vector pEGFP-C1 for transfection of NIH3T3 and HEK-293 cells | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleolus | - |
Homo sapiens | 5730 | - |
| nucleolus | - |
Mus musculus | 5730 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 34000 | - |
determined by SDS-PAGE and Western Blot analysis | Homo sapiens |
| 72000 | - |
determined by SDS-PAGE and Western Blot analysis | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? |  |
| ATP + a protein | Mus musculus | - |
ADP + a phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | Q4FZD7 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| nucleoli are prepared from NIH3T3 cells | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
| retina | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
| ATP + a protein | - |
Mus musculus | ADP + a phosphoprotein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| hPlk5 | - |
Homo sapiens |
| mPlk5 | - |
Mus musculus |
| Plk5 | - |
Homo sapiens |
| Plk5 | - |
Mus musculus |
| polo-like kinase 5 | - |
Homo sapiens |
| polo-like kinase 5 | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| ATP | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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