Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activation of SmPlk1 requires phosphorylation of the conserved threonine residue Thr182 | Schistosoma mansoni |
Application | Comment | Organism |
---|---|---|
medicine | potential new target against schistosomiasis | Schistosoma mansoni |
Cloned (Comment) | Organism |
---|---|
into the pDrive cloning vector for sequencing, into the pCR2.1-TOPO and V5His-tagged pcDNA3.1 expression vectors | Schistosoma mansoni |
Protein Variants | Comment | Organism |
---|---|---|
SmPlk1DK | dead kinase version of SmPlk1, obtained by replacing the D166FG168 active motif by a D166NA168 inactive motif | Schistosoma mansoni |
SmPlk1T182D | constitutively active mutant | Schistosoma mansoni |
SmPlk1T182D-DK | double mutant | Schistosoma mansoni |
SmPlk1T182V | inactive mutant | Schistosoma mansoni |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BI2536 | - |
Schistosoma mansoni | |
GW843682X | - |
Schistosoma mansoni | |
LY294002 | - |
Schistosoma mansoni | |
Wortmannin | - |
Schistosoma mansoni |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
70500 | - |
theoretical | Schistosoma mansoni |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Schistosoma mansoni | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schistosoma mansoni | Q5UES2 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Schistosoma mansoni |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
germ cell | germinal cell of schistosome | Schistosoma mansoni | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Schistosoma mansoni | ADP + a phosphoprotein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Plk1 | - |
Schistosoma mansoni |
Polo-like kinase 1 | - |
Schistosoma mansoni |
SmPlk1 | - |
Schistosoma mansoni |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Schistosoma mansoni |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Schistosoma mansoni | theoretical | - |
9.13 |
General Information | Comment | Organism |
---|---|---|
physiological function | conserved function in mitotic processes | Schistosoma mansoni |