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Literature summary for 2.7.11.21 extracted from

  • Shi, W.; Alajez, N.M.; Bastianutto, C.; Hui, A.B.; Mocanu, J.D.; Ito, E.; Busson, P.; Lo, K.W.; Ng, R.; Waldron, J.; OSullivan, B.; Liu, F.F.
    Significance of Plk1 regulation by miR-100 in human nasopharyngeal cancer (2010), Int. J. Cancer, 126, 2036-2048.
    View publication on PubMed

Application

Application Comment Organism
medicine targeting Plk1 will cause mitotic catastrophe, with significant cytotoxicity both in vitro and in vivo, underscoring the important therapeutic opportunity of Plk1 in nasopharyngeal cancer Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
the Plk1 3'-UTR region is amplified and cloned downstream of the luciferase gene into the pMIRREPORT luciferase vector Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNA
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Homo sapiens
-
ADP + a phosphoprotein
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P53350
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C666-1 cell
-
Homo sapiens
-
HK-1 cell
-
Homo sapiens
-
nasopharyngeal carcinoma cell NPC biopsy block Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
Homo sapiens ADP + a phosphoprotein
-
?

Synonyms

Synonyms Comment Organism
Plk1
-
Homo sapiens
Polo-like kinase 1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens Plk expression is regulated by the microRNAs miR-100 and miR-142-5p down
Homo sapiens overexpression of Plk1 is commonly observed in many human malignancies, Plk expression is regulated by the microRNAs miR-100 and miR-142-5p up

General Information

General Information Comment Organism
physiological function Plk1 is a critical regulator of many stages of mitosis Homo sapiens