Application | Comment | Organism |
---|---|---|
medicine | targeting Plk1 will cause mitotic catastrophe, with significant cytotoxicity both in vitro and in vivo, underscoring the important therapeutic opportunity of Plk1 in nasopharyngeal cancer | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
the Plk1 3'-UTR region is amplified and cloned downstream of the luciferase gene into the pMIRREPORT luciferase vector | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
siRNA | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P53350 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C666-1 cell | - |
Homo sapiens | - |
HK-1 cell | - |
Homo sapiens | - |
nasopharyngeal carcinoma cell | NPC biopsy block | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Plk1 | - |
Homo sapiens |
Polo-like kinase 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | Plk expression is regulated by the microRNAs miR-100 and miR-142-5p | down |
Homo sapiens | overexpression of Plk1 is commonly observed in many human malignancies, Plk expression is regulated by the microRNAs miR-100 and miR-142-5p | up |
General Information | Comment | Organism |
---|---|---|
physiological function | Plk1 is a critical regulator of many stages of mitosis | Homo sapiens |