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Literature summary for 2.7.11.21 extracted from
- Biological impact of freezing Plk1 in its inactive conformation in cancer cells (2010), Cell Cycle, 9, 761-773.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | targeting Plk1 might be a promising approach for cancer therapy | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| T210D | hyperactive mutant | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| SBE13 | selective type II Plk1 inhibitor | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | phosphorylated by Aurora A | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-431 cell | - |
Homo sapiens | - |
| Detroit 562 cell | - |
Homo sapiens | - |
| HCT-115 cell | - |
Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
| HT-29 cell | - |
Homo sapiens | - |
| LN-229 cell | - |
Homo sapiens | - |
| MCF-7 cell | - |
Homo sapiens | - |
| PC-3 cell | - |
Homo sapiens | - |
| SKW6.4 cell | - |
Homo sapiens | - |
| U2-OS cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Plk1 | - |
Homo sapiens |
| Polo-like kinase 1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
kinase assay | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000002 | - |
immunoprecipitated Plk1 from HeLa cells | Homo sapiens | SBE13 | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | overexpressed in various tumors | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Plk1 is a key regulator of mitosis | Homo sapiens |
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Release 2023.1 (January 2023)
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