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Literature summary for 2.7.11.21 extracted from

  • Duan, Z.; Ji, D.; Weinstein, E.J.; Liu, X.; Susa, M.; Choy, E.; Yang, C.; Mankin, H.; Hornicek, F.J.
    Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma (2010), Cancer Lett., 293, 220-229.
    View publication on PubMed
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Application

Application Comment Organism
medicine PLK1 can be a potential therapeutic target for the treatment of osteosarcoma Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
into the vector pCMV6-XL5 for transfection Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
scytonemin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Homo sapiens
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P53350
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HFOB 1.19 cell osteoblast cell Homo sapiens
-
HOB-c cell osteoblast cell Homo sapiens
-
KHOS cell osteosarcoma cell line Homo sapiens
-
NHOst cell osteoblast cell Homo sapiens
-
OSA-344 cell osteosarcoma cell line Homo sapiens
-
SAOS-2 cell osteosarcoma cell line Homo sapiens
-
U2-OS cell osteosarcoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Homo sapiens ADP + a phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
Plk1
-
 Homo sapiens
Polo-like kinase 1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens PLK1 is highly expressed in sarcoma cell lines and in osteosarcoma tissues up