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Literature summary for 2.7.11.21 extracted from

  • Uckun, F.M.; Ozer, Z.; Qazi, S.; Tuel-Ahlgren, L.; Mao, C.
    Polo-like-kinase 1 (PLK1) as a molecular target to overcome SYK-mediated resistance of B-lineage acute lymphoblastic leukaemia cells to oxidative stress (2010), Br. J. Haematol., 148, 714-725.
    View publication on PubMed
Search for more literature for 2.7.11.21

Inhibitors

Inhibitors Comment Organism Structure
2-cyano-3-hydroxy-3-methyl-N-[4-(trifluoromethoxy)phenyl]-propenamide LFM-A12 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
67000
-
 determined by SDS-PAGE and Western Blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Homo sapiens
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P53350
-
-

Purification (Commentary)

Purification (Comment) Organism
SYK and PLK1 immune complexes immunoprecipitated from whole cell lysates of NALM-6 and BT-20 cell lines Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
acute lymphoblastic leukemia cell
-
 Homo sapiens
-
BT-20 cell
-
 Homo sapiens
-
NALM-6 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Homo sapiens ADP + a phosphoprotein
-
 ?
ATP + SYK tyrosine kinase
-
 Homo sapiens ADP + phosphorylated SYK tyrosine kinase
-
 ?

Synonyms

Synonyms Comment Organism
Plk1
-
 Homo sapiens
polo-like-kinase 1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function PLK1 is the upstream regulator of SYK tyrosine kinase in B-lineage acute lymphoblastic leukemia cells Homo sapiens