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Literature summary for 2.7.11.21 extracted from

  • Nishi, Y.; Rogers, E.; Robertson, S.M.; Lin, R.
    Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6 (2008), Development, 135, 687-697.
    View publication on PubMed
Search for more literature for 2.7.11.21

Cloned(Commentary)

Cloned (Comment) Organism
FLAG-tagged PLK1 is constructed Homo sapiens
for a yeast two-hybrid screen Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
N166A kinase dead mutant Caenorhabditis elegans

Localization

Localization Comment Organism GeneOntology No. Textmining
centrosome
-
 Caenorhabditis elegans 5813
-
chromosome
-
 Caenorhabditis elegans 5694
-
cytoplasm
-
 Caenorhabditis elegans 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein Homo sapiens
-
 ADP + phosphoprotein
-
 ?
ATP + protein Caenorhabditis elegans
-
 ADP + phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Caenorhabditis elegans
-
HEK-293T cell
-
 Homo sapiens
-
larva
-
 Caenorhabditis elegans
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Cdc25C
-
 Caenorhabditis elegans ADP + phosphorylated Cdc25C
-
 ?
ATP + MEX-5
-
 Homo sapiens ADP + phosphorylated MEX-5
-
 ?
ATP + protein
-
 Homo sapiens ADP + phosphoprotein
-
 ?
ATP + protein
-
 Caenorhabditis elegans ADP + phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
HsPlk1
-
 Homo sapiens
Polo kinase
-
 Homo sapiens
Polo kinase
-
 Caenorhabditis elegans

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Caenorhabditis elegans